Protein Alignment Polr2B and RpI135

DIOPT Version :10

• Sequence 1: NP_476706.1
• Gene: Polr2B / 41721
• FlyBaseID: FBgn0262955
• Length: 1176
• Species: Drosophila melanogaster
• Sequence 2: XP_310152.5
• Gene: RpI135 / 1271371
• VectorBaseID: AGAMI1_014708
• Length: 1145
• Species: Anopheles gambiae
• Alignment Length: 1264
• Identity: 351/1264 - (27%)
• Similarity: 536/1264 - (42%)
• Gaps: 277/1264 - (21%)

  Fly    40 LVRQQLDSF----DEFIQMSVQRIVEDSPAIELQAEAQHTSGEVETPPRFSLKFEQIYLSKPTHW 100
            |.|..:|||    ||.|:..:.|:|.             ...|:....|..|:...|.::.||
Mosquito    28 LGRPHIDSFNYMLDEGIEDVLSRLVP-------------VCFEMANGSRIKLRITDISIAPPT-- 77

  Fly   101 EKDGSPSPMM----------PNEARLRNLTYSAPLYVDITKTKNVEGL--DPVETQHQKTFIGKI 153
                  .|||          |:|.|.::.||:.  ...||....::|:  .|:..:     :|:|
Mosquito    78 ------VPMMLVEVAEKRVFPSECRQKSDTYAG--MCTITLNWELDGMPQSPLTRE-----MGRI 129

  Fly   154 PIMLRSTYCLLSQLTDRDLTELNECPLDPGGYFIINGSEK---VLIAQEK---MATNT------- 205
            ||||||..|.|:..|..:|....|...:.||||::.|:||   :||:..:   :|.|.
Mosquito   130 PIMLRSNACNLANATPEELVARGEHEDEWGGYFVVRGNEKLIRMLISTRRNYPIAVNRNTWRDRG 194

  Fly   206 -------VYVFSMKDGKYAFKTEIRSCLEHSSRPTSTLWVNMMARGSQNIKKSAIGQRIIAILPY 263
                   |::..:::.:|:    .|:.|.:.:..|:.|.:::              .|.::.
Mosquito   195 KDFSATGVFIRCVREDQYS----TRNVLHYLTNGTAKLMISV--------------SRALSF--- 238

  Fly   264 IKQEIPIMIVFRALGFVADRDILEHI-IYDFDDPEMMEMVKPSLDEAFVVQEQNVALNFIGARGA 327
                ||:|::.:|||..:|.:|.:.: ..|..|......:...|.:..       |.|...::..
Mosquito   239 ----IPVMMILKALGDRSDNEIYKKLTACDESDQYYKRCIMAMLRDLH-------AENLHSSQEC 292

  Fly   328 RP--GVTKDKRIK-------YAKE-----ILQKEMLPHV-GVSDFCETKKAYFLGYMVHRLLLAS 377
            |.  |:...:|:.       |:.|     :||..:|.|: .|.|     |...|.:|||:|....
Mosquito   293 RSYMGMLLRRRLMDINLPAWYSDEQAGHFLLQHCVLIHLDSVED-----KFNLLVHMVHKLYAVV 352

  Fly   378 LGRRELDDRDHYGNKRLDLAGPLLAFLFRGLFKNLMKEVRMYTQKFI-DRGKDF----NLELAIK 437
            .||..::..|....:.:.|.|.:...|.|.:..:.|:.||:...|.. ||....    .|..|:|
Mosquito   353 QGRHAVESLDGTMMQEILLGGHIYQGLLREMCLSTMQYVRINLMKLCPDRTSPMVTTHELAQALK 417

  Fly   438 TNIITDGLRYS----LATGNWGDQKKAHQARAG---------VSQVLNRLTFASTLSHLRRVNSP 489
             |:.  |.::.    |||||     .|.....|         :::.:||:.:   :||.|.|:
Mosquito   418 -NVA--GFQHPFTMFLATGN-----LAKATEMGLMQSTGLVIIAENINRMRY---MSHFRAVH-- 469

  Fly   490 IGRDG-----KLAKPRQLHNTLWGMLCPAETPEGAAVGLVKNLALMAYISVGSQPSPILEF---L 546
              |..     :..:.|||....||.:||..||:|...||:.::.....:||...|..:...   |
Mosquito   470 --RGSYFLTMRTTEARQLLPDAWGFICPVHTPDGEPCGLLNHMTSDCTVSVTQDPELVANIPATL 532

  Fly   547 EEWSMENLEEIAPS----AIADATKIFVNGCWVGI--HRDPEQLMATLRKLRRQMDIIVSEVSMI 605
            ....|:.....|.|    :..|...:.:.|..:|:  .....|::..||.|:.:...|.::.. |
Mosquito   533 VSLGMQPFGGDAGSFGTLSHDDGYVVMLEGKMLGMLARATASQVVQKLRLLKIEGKTIPNQTE-I 596

  Fly   606 RDIRDRE------IRIYTDAGRICRPLLIVENGSLLLKKTHVEMLKERDYNNYSWQVLVASGVVE 664
            ..:..||      :.::....|:.||   |:|  ||..||                        |
Mosquito   597 AFVPAREGGQYPGLFLFVGPARMMRP---VKN--LLCGKT------------------------E 632

  Fly   665 YIDTLEEETVMIAMSPYDLKQDKDYAYCTTYTHCEIHPAMILGVCASIIPFPDHNQSPRNTYQSA 729
            .|.:.|:..:.|.::|       :.||....||.|:.....:...|.:||.||.||||||.||..
Mosquito   633 LIGSFEQVYMDICVTP-------EEAYPQLTTHAELAKTSFMSNLAQLIPMPDCNQSPRNMYQCQ 690

  Fly   730 MGKQAMGVYITNFHVRMDTLAHVLYYPMKPLVTTRSMEYLRFRELPAGINSIVAILCYTGYNQED 794
            ||||.||....|:..:.....:.|..|..||......:.:.......|.|:|||::.||||:.||
Mosquito   691 MGKQTMGTPCHNWDKQCIAKMYRLQTPATPLFRPVHHDNIALDNYAMGTNAIVAVISYTGYDMED 755

  Fly   795 SVILNASAVERGFFRSVFYRSYKDSENKRVGDQEENF--EKPHRGTCQGMRNAHYDKLDDDGIIA 857
            ::|:|.:|.||||...   ..||....:..||   :|  ..|...|....       ||:||
Mosquito   756 AMIINKAAFERGFAAG---NIYKHEYVELTGD---SFFARNPKDATLNPF-------LDNDG--- 804

  Fly   858 PGIRVSGDDVVIGKTITLPENDDELDSNTKRFSKRDAS--TF----LRNSETGIVDQVML--TLN 914
                             ||....:|...|..:...|.:  |:    .:..|..|||.|.|  .|.
Mosquito   805 -----------------LPFKGAQLTKGTPLYCYFDVNDHTYHVVSYQGYEEAIVDNVKLGAPLQ 852

  Fly   915 SEG-----------YKFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQEDMAFTCEGLAPDII 968
            ..|           .|...:..|..|.|.:|||||||.||||.|...:...|:.||..|:.||||
Mosquito   853 DAGRGIGRGGMAIVTKQLILTYRVPRNPSVGDKFASRAGQKGICSQHWPAIDLPFTESGMIPDII 917

  Fly   969 INPHAIPSRMTIGHLIECLQGKLGSNKGEIGDATPFN-DAVN--VQKISTFLQEYGYHLRGNEVM 1030
            .|||..||||||..:||.:.||..:.:|.:.|||||. |..|  :......|::.||...|.|.|
Mosquito   918 FNPHGFPSRMTIAMMIETMAGKTAACQGLVHDATPFRYDESNTAIDYFGRLLEQSGYDYYGTERM 982

  Fly  1031 YNGHTGRKINAQVFLGPTYYQRLKHMVDDKIHSRARGPVQILVRQPMEGRARDGGLRFGEMERDC 1095
            |:|..||::...:|.|..:||||:|||.||...|:.||:..|..||.:||:|.||:||||||||.
Mosquito   983 YSGVDGREMKVDIFFGVVHYQRLRHMVSDKWQVRSTGPIDQLTHQPNKGRSRGGGVRFGEMERDG 1047

  Fly  1096 QISHGAAQFLRERLFEVSDPYRVHICNFCGLI------AIANLRNNTFE-------CKGCKNKTQ 1147
            .|||||:..|::||...||.....:|..||.:      ....|.:|:.:       |:.|::..:
Mosquito  1048 LISHGASFLLQDRLVHGSDKVVALVCRRCGTLIGPIDSVTKRLADNSNQLQHVPATCRLCEDDKE 1112

  Fly  1148 ISQVRLPYAAKLLFQELMSMNIAPRLMVT 1176
            |..|.:||..|.|..:|.||||..:|.::
Mosquito  1113 IGHVEIPYIFKFLVSQLTSMNINVKLQLS 1141

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Polr2B	NP_476706.1	Ricin_B_lectin	28..1176	CDD:481363	351/1262 (28%)
RpI135	XP_310152.5	None