DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment 140up and Timmdc1

DIOPT Version :9

Sequence 1:	NP_001262561.1	Gene:	140up / 41720	FlyBaseID:	FBgn0010340	Length:	261	Species:	Drosophila melanogaster
Sequence 2:	NP_077235.2	Gene:	Timmdc1 / 76916	MGIID:	1922139	Length:	285	Species:	Mus musculus

Alignment Length:	222	Identity:	69/222 - (31%)
Similarity:	122/222 - (54%)	Gaps:	7/222 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 RFLIAGILPTFEGAADEIVDKENKTYKAFLASKPPEETGLERLKQMFTIDEFGSISSELNSVYQA 73
            |...||.:     |||.....|::..::.::.....|:|.:||:|:|..||....|.|::.:|:|
Mouse    21 RVFAAGAV-----AADSPGFVEDREQRSGVSDPGSLESGWDRLRQLFAKDEQQRFSKEIDYIYRA 80

  Fly    74 GFLGFLIGAIYGGVTQSRVAYMNFMENNQATAFKSHFDAKKKLQDQFTVNFAKGGFKWGWRVGLF 138
            .....:||..|||:.....|...::|.:||..:.:.|||.:......|..|.:.|::|.||..:|
Mouse    81 AVSAGIIGWAYGGIPAFIYAKKRYIEQSQAEIYHNRFDAVQSAHRAATRGFIRYGWRWSWRTAVF 145

  Fly   139 TTSYFGIITCMSVYRGKSSIYEYLAAGSITGSLYKVSLGLRGMAAGGIIGGFLGGVAGVTSLLLM 203
            .|.:..:.|.::|||.|.::..:..||::||.|::::||:||:.||.|||..||...|...:.|.
Mouse   146 VTIFNTVNTGLTVYRNKDAMSHFAIAGAVTGGLFRINLGVRGLVAGSIIGALLGAPMGSLLMALE 210

  Fly   204 KASGTSMEEVRYWQYKWRLDRDENIQQ 230
            |.||.:::|.|  |.:|:...::.:::
Mouse   211 KYSGETVQERR--QKEWKALHEQRLEE 235

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
140up	NP_001262561.1	Tim17	67..179	CDD:280604	34/111 (31%)
Timmdc1	NP_077235.2	Tim17	74..203	CDD:280604	43/128 (34%)
Timmdc1	NP_077235.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	265..285
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846899
Domainoid	1	1.000	89	1.000	Domainoid score	I7890
eggNOG	1	0.900	-	-		E1_KOG4608
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9578
Inparanoid	1	1.050	128	1.000	Inparanoid score	I4655
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007047
OrthoInspector	1	1.000	-	-		oto92668
orthoMCL	1	0.900	-	-		OOG6_107776
Panther	1	1.100	-	-	LDO	PTHR13002
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3417
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.780