DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment twf and TWF1

DIOPT Version :9

Sequence 1:	NP_650338.1	Gene:	twf / 41719	FlyBaseID:	FBgn0038206	Length:	343	Species:	Drosophila melanogaster
Sequence 2:	NP_001229326.1	Gene:	TWF1 / 5756	HGNCID:	9620	Length:	357	Species:	Homo sapiens

Alignment Length:	351	Identity:	168/351 - (47%)
Similarity:	252/351 - (71%)	Gaps:	9/351 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSHQTGIRANEQLAKVFGKAKNGKFRVIKVSIENEQLSCGATAETKKDWERDYDKLIGPLLEKDV 65
            |||||||:|:|.:.::|.:|:|||:|::|:|||||||..|:.::....|::|||..:.||||...
Human     1 MSHQTGIQASEDVKEIFARARNGKYRLLKISIENEQLVIGSYSQPSDSWDKDYDSFVLPLLEDKQ 65

  Fly    66 PCYILYRLDAKIPLGYSWLLISWTPDTASIRQKMVYASTKATLKTEFGSAYITEELHATTLDECT 130
            |||||:|||::...||.|:.|:|:||.:.:||||:||:|:||||.|||..:|.:|:..|..::.:
Human    66 PCYILFRLDSQNAQGYEWIFIAWSPDHSHVRQKMLYAATRATLKKEFGGGHIKDEVFGTVKEDVS 130

  Fly   131 LEGYRRHKQDFAAPAPLTSREEELKELRKTE-------VHTEINTNTRHQTLGGINCPLSEATVA 188
            |.||:::....::|||||:.||||::::..|       |.|::..:|:||||.|:..|:|.....
Human   131 LHGYKKYLLSQSSPAPLTAAEEELRQIKINESPEDHIGVQTDVGVDTKHQTLQGVAFPISREAFQ 195

  Fly   189 AVQDLVRGKHDYLQFRIDLEEEQIHVSRAAKVELADLPKQVPEDHARYHLFLFRHTHEGDYFESY 253
            |::.|...:.:|:|..||::.|.|.::.....||.||||::|:|.||||.||::|:|||||.||.
Human   196 ALEKLNNRQLNYVQLEIDIKNEIIILANTTNTELKDLPKRIPKDSARYHFFLYKHSHEGDYLESI 260

  Fly   254 VFVYSMPGYSCSVRERMMYSSCKAPFLDEL-AALGVEVVKKLEIDSGSELTEAFLQDELHPKKIL 317
            ||:||||||:||:||||:|||||:..|:.: ..|.::|::|:|||:|.|||..||.:|:|||:..
Human   261 VFIYSMPGYTCSIRERMLYSSCKSRLLEIVERQLQMDVIRKIEIDNGDELTADFLYEEVHPKQHA 325

  Fly   318 HRPAFAKPKGPP-NRGAKRLTRPTAE 342
            |:.:|||||||. .||.:||.|..||
Human   326 HKQSFAKPKGPAGKRGIRRLIRGPAE 351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
twf	NP_650338.1	ADF_Twf-N_like	4..142	CDD:200441	64/137 (47%)
twf	NP_650338.1	ADF_Twf-C_like	176..310	CDD:200440	65/134 (49%)
TWF1	NP_001229326.1	ADF_Twf-N_like	4..142	CDD:200441	64/137 (47%)
		ADF_Twf-C_like	183..318	CDD:200440	65/134 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	323..357		15/29 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159561
Domainoid	1	1.000	136	1.000	Domainoid score	I4931
eggNOG	1	0.900	-	-		E1_KOG1747
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H48140
Inparanoid	1	1.050	369	1.000	Inparanoid score	I2144
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54608
OrthoDB	1	1.010	-	-		D1578109at2759
OrthoFinder	1	1.000	-	-		FOG0001842
OrthoInspector	1	1.000	-	-		otm42265
orthoMCL	1	0.900	-	-		OOG6_102985
Panther	1	1.100	-	-	O	PTHR13759
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1569
SonicParanoid	1	1.000	-	-		X134
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800