DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment twf and twf2b

DIOPT Version :9

Sequence 1:	NP_650338.1	Gene:	twf / 41719	FlyBaseID:	FBgn0038206	Length:	343	Species:	Drosophila melanogaster
Sequence 2:	XP_009304210.1	Gene:	twf2b / 553677	ZFINID:	ZDB-GENE-050522-238	Length:	369	Species:	Danio rerio

Alignment Length:	365	Identity:	162/365 - (44%)
Similarity:	226/365 - (61%)	Gaps:	22/365 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSHQTGIRANEQLAKVFGKAKNGKFRVIKVSIENEQLSCGATAETKKDWERDYDKLIGPLLEKDV 65
            |||||||.|...|.:...||:.|.||.:|:.|.:|||..||..|..:.|::|||..:.|:|:...
Zfish     1 MSHQTGIHATSDLREFLIKARRGAFRALKIVIRSEQLVLGAYREVSQSWDQDYDACVLPMLDGLE 65

  Fly    66 PCYILYRLDAKIPLGYSWLLISWTPDTASIRQKMVYASTKATLKTEFGSAYITEELHATTLDECT 130
            |||||||||:...|||.||.|||:||.:.:|.|||||:|:||||.|||.::|.:|:..|..::.:
Zfish    66 PCYILYRLDSHNQLGYEWLFISWSPDQSPVRLKMVYAATRATLKKEFGGSHINDEVFGTVQEDIS 130

  Fly   131 LEGYRRHKQDFAAPAPLTSREEELKELRKTE--------------------VHTEINTNTRHQTL 175
            .:||.||....:.|||||:.|::|.:::.||                    ..||||..:::.||
Zfish   131 FQGYLRHLSSSSCPAPLTTAEQQLHQIKITEDKVARDERRIVRPVATVSGQGKTEINVESKNPTL 195

  Fly   176 GGINCPLSEATVAAVQDLVRGKHDYLQFRIDLEEEQIHVSRAAKVELADLPKQVPEDHARYHLFL 240
            .|:..||.|....|:|.....:.:|:|.|:|.|.|.|.:...:..|..:||.::|.|..|||.||
Zfish   196 QGLAFPLQEEAKHALQQFKHKRINYIQLRLDTERETIELVHTSPTETKELPSRIPTDAPRYHFFL 260

  Fly   241 FRHTHEGDYFESYVFVYSMPGYSCSVRERMMYSSCKAPFLDELAA-LGVEVVKKLEIDSGSELTE 304
            ::|.|:|...|:.||:|||||||||::|||:|||||...|||:.. ..:|:.||:||:||..|||
Zfish   261 YKHAHQGQPLEAVVFIYSMPGYSCSIKERMLYSSCKNRLLDEVERDYHIEIAKKMEIESGDGLTE 325

  Fly   305 AFLQDELHPKKILHRPAFAKPKGPP-NRGAKRLTRPTAED 343
            .||.:|::||....|.||:|||||. .||.|||.|...|:
Zfish   326 DFLYEEVYPKHHALRQAFSKPKGPTGKRGNKRLIRGAGEN 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
twf	NP_650338.1	ADF_Twf-N_like	4..142	CDD:200441	65/137 (47%)
twf	NP_650338.1	ADF_Twf-C_like	176..310	CDD:200440	61/134 (46%)
twf2b	XP_009304210.1	ADF_Twf-N_like	4..142	CDD:200441	65/137 (47%)
twf2b	XP_009304210.1	ADF_Twf-C_like	196..331	CDD:200440	61/134 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595752
Domainoid	1	1.000	143	1.000	Domainoid score	I4589
eggNOG	1	0.900	-	-		E1_KOG1747
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	362	1.000	Inparanoid score	I2151
OMA	1	1.010	-	-		QHG54608
OrthoDB	1	1.010	-	-		D1578109at2759
OrthoFinder	1	1.000	-	-		FOG0001842
OrthoInspector	1	1.000	-	-		otm26238
orthoMCL	1	0.900	-	-		OOG6_102985
Panther	1	1.100	-	-	O	PTHR13759
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X134
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.770