Protein Alignment twf and TLR9

DIOPT Version :10

• Sequence 1: NP_650338.1
• Gene: twf / 41719
• FlyBaseID: FBgn0038206
• Length: 343
• Species: Drosophila melanogaster
• Sequence 2: NP_059138.1
• Gene: TLR9 / 54106
• HGNCID: 15633
• Length: 1032
• Species: Homo sapiens
• Alignment Length: 118
• Identity: 29/118 - (24%)
• Similarity: 39/118 - (33%)
• Gaps: 41/118 - (34%)

  Fly    59 PLLEKDVPCYILYRLDAKI--PLGYSWLLISWTPDTASIR-----QKMVY---ASTKA------- 106
            |.|..|...: |.||:..:  ....|||..||.....::|     :..:|   ..|||
Human   273 PQLHPDTFSH-LSRLEGLVLKDSSLSWLNASWFRGLGNLRVLDLSENFLYKCITKTKAFQGLTQL 336

  Fly   107 ------------------TLKTEFGSAYITEEL--HA---TTLDECTLEGYRR 136
                              :|...|||....:||  |.   .:|||.||....|
Human   337 RKLNLSFNYQKRVSFAHLSLAPSFGSLVALKELDMHGIFFRSLDETTLRPLAR 389

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
twf	NP_650338.1	ADF_Twf-N_like	4..142	CDD:200441	29/118 (25%)
		ADF_Twf-C_like	176..310	CDD:200440
TLR9	NP_059138.1	leucine-rich repeat	43..64	CDD:275380
		LRR 1	62..85
		LRR_8	64..135	CDD:404697
		leucine-rich repeat	65..88	CDD:275380
		LRR 2	87..110
		leucine-rich repeat	89..124	CDD:275380
		LRR	113..504	CDD:443914	29/118 (25%)
		LRR 3	122..147
		leucine-rich repeat	125..144	CDD:275380
		leucine-rich repeat	145..168	CDD:275380
		LRR 4	150..166
		LRR 5	167..190
		leucine-rich repeat	169..200	CDD:275380
		LRR 6	198..221
		leucine-rich repeat	201..221	CDD:275380
		leucine-rich repeat	222..245	CDD:275380
		LRR 7	223..242
		LRR 8	243..268
		leucine-rich repeat	246..285	CDD:275380	4/12 (33%)
		LRR 9	283..306		8/22 (36%)
		leucine-rich repeat	286..307	CDD:275380	6/20 (30%)
		LRR 10	308..332		5/23 (22%)
		leucine-rich repeat	310..335	CDD:275380	5/24 (21%)
		LRR 11	333..356		0/22 (0%)
		leucine-rich repeat	336..365	CDD:275380	4/28 (14%)
		LRR 12	363..386		8/22 (36%)
		leucine-rich repeat	366..392	CDD:275380	9/24 (38%)
		LRR 13	390..413		29/118 (25%)
		leucine-rich repeat	393..416	CDD:275380
		LRR 14	415..440
		leucine-rich repeat	417..472	CDD:275380
		LRR 15	470..494
		leucine-rich repeat	476..497	CDD:275380
		LRR	495..>739	CDD:443914
		LRR 16	496..519
		leucine-rich repeat	498..522	CDD:275380
		LRR 17	520..543
		leucine-rich repeat	523..546	CDD:275380
		LRR 18	545..572
		leucine-rich repeat	547..599	CDD:275380
		LRR 19	574..598
		leucine-rich repeat	600..629	CDD:275380
		LRR 20	600..622
		LRR 21	627..650
		leucine-rich repeat	630..654	CDD:275380
		LRR 22	652..675
		leucine-rich repeat	655..678	CDD:275380
		LRR 23	676..699
		leucine-rich repeat	679..702	CDD:275380
		LRR 24	701..723
		leucine-rich repeat	703..726	CDD:275380
		LRR 25	724..747
		leucine-rich repeat	727..748	CDD:275380
		LRR 26	749..772
		leucine-rich repeat	752..770	CDD:275380
		SEFIR	870..1009	CDD:474043