DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment twf and twf1

DIOPT Version :9

Sequence 1:	NP_650338.1	Gene:	twf / 41719	FlyBaseID:	FBgn0038206	Length:	343	Species:	Drosophila melanogaster
Sequence 2:	NP_001011469.1	Gene:	twf1 / 496960	XenbaseID:	XB-GENE-489056	Length:	350	Species:	Xenopus tropicalis

Alignment Length:	344	Identity:	169/344 - (49%)
Similarity:	250/344 - (72%)	Gaps:	2/344 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSHQTGIRANEQLAKVFGKAKNGKFRVIKVSIENEQLSCGATAETKKDWERDYDKLIGPLLEKDV 65
            |||||||:|:|.:.::|.:|:|||:|::|:.||:|||:..|..:....||::||.||.||||...
Frog     1 MSHQTGIQASEDVLEMFARARNGKYRLLKLDIEDEQLTVTACEKPASSWEQEYDSLILPLLEDKQ 65

  Fly    66 PCYILYRLDAKIPLGYSWLLISWTPDTASIRQKMVYASTKATLKTEFGSAYITEELHATTLDECT 130
            ||||:||||::...|:.|:.|:|:||.:.:||||:||:|:||:|.|||..:|.|||..|..|:.:
Frog    66 PCYIMYRLDSQNAQGFEWIFIAWSPDHSHVRQKMLYAATRATVKKEFGGGHIKEELFGTVKDDIS 130

  Fly   131 LEGYRRHKQDFAAPAPLTSREEELKELRKTEVHTEINTNTRHQTLGGINCPLSEATVAAVQDLVR 195
            |:||.::....::|||||..||||::::..|...:|..:|:||||.||..|:.:|...|::.|..
Frog   131 LKGYYKYLACQSSPAPLTMAEEELRQIKIKETQVDIGVDTKHQTLQGIAFPIEKAAFQALEQLRE 195

  Fly   196 GKHDYLQFRIDLEEEQIHVSRAAKVELADLPKQVPEDHARYHLFLFRHTHEGDYFESYVFVYSMP 260
            .:.:|:|.:||::.|.|.::.....|:.||||::|:|.||||.||::|:|||||.:|:||:||||
Frog   196 KRLNYVQLKIDIKNETIILADTTNTEVRDLPKRIPKDAARYHFFLYKHSHEGDYLDSFVFIYSMP 260

  Fly   261 GYSCSVRERMMYSSCKAPFLDELA-ALGVEVVKKLEIDSGSELTEAFLQDELHPKKILHRPAFAK 324
            ||:||:||||:|||||:|.||.:. .|.:|:.:|:|||:|.|||..||.:|:|||:..|:..|||
Frog   261 GYTCSIRERMLYSSCKSPLLDVIENRLLMEIARKIEIDNGDELTPDFLYEEVHPKQHAHKQNFAK 325

  Fly   325 PKGPP-NRGAKRLTRPTAE 342
            ||||. .||.:||.|..||
Frog   326 PKGPAGKRGIRRLIRGPAE 344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
twf	NP_650338.1	ADF_Twf-N_like	4..142	CDD:200441	65/137 (47%)
twf	NP_650338.1	ADF_Twf-C_like	176..310	CDD:200440	66/134 (49%)
twf1	NP_001011469.1	ADF_Twf-N_like	4..142	CDD:200441	65/137 (47%)
		ADF_Twf-C_like	176..311	CDD:200440	66/134 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	316..350		15/29 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	141	1.000	Domainoid score	I4676
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H48140
Inparanoid	1	1.050	364	1.000	Inparanoid score	I2118
OMA	1	1.010	-	-		QHG54608
OrthoDB	1	1.010	-	-		D1578109at2759
OrthoFinder	1	1.000	-	-		FOG0001842
OrthoInspector	1	1.000	-	-		otm49495
Panther	1	1.100	-	-	O	PTHR13759
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1569
SonicParanoid	1	1.000	-	-		X134
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110