DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment twf and twf1b

DIOPT Version :9

Sequence 1:	NP_650338.1	Gene:	twf / 41719	FlyBaseID:	FBgn0038206	Length:	343	Species:	Drosophila melanogaster
Sequence 2:	NP_001002304.1	Gene:	twf1b / 432375	ZFINID:	ZDB-GENE-040711-3	Length:	349	Species:	Danio rerio

Alignment Length:	340	Identity:	164/340 - (48%)
Similarity:	243/340 - (71%)	Gaps:	2/340 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSHQTGIRANEQLAKVFGKAKNGKFRVIKVSIENEQLSCGATAETKKDWERDYDKLIGPLLEKDV 65
            |||||||:|..::.::|.||:||::|:|||.||||:|..|.:....|.|::::|..:.||:|.|:
Zfish     1 MSHQTGIQATGEVKEIFAKARNGEYRLIKVVIENEKLVLGGSKRAAKKWDQEWDGCVLPLVEDDM 65

  Fly    66 PCYILYRLDAKIPLGYSWLLISWTPDTASIRQKMVYASTKATLKTEFGSAYITEELHATTLDECT 130
            |.|:|:|||.....||.|:.::|:||.:.:||||:||:|:||||.|||..:|.||:..|..|:.:
Zfish    66 PSYLLFRLDTTNNQGYEWVFLAWSPDHSPVRQKMLYAATRATLKKEFGGGHIKEEIFGTVKDDVS 130

  Fly   131 LEGYRRHKQDFAAPAPLTSREEELKELRKTEVHTEINTNTRHQTLGGINCPLSEATVAAVQDLVR 195
            |.||:::....|||.|||:.||||::::..|:.|:::.:|:.|||.|:..|:....:.|::....
Zfish   131 LNGYKKYLSSQAAPLPLTAAEEELRQIKLNELQTDVHVDTKQQTLQGVAFPMQRDAIQALEQFRD 195

  Fly   196 GKHDYLQFRIDLEEEQIHVSRAAKVELADLPKQVPEDHARYHLFLFRHTHEGDYFESYVFVYSMP 260
            .:.:|:|..||...|.|.:|..|..:|.||||::|:|.||||.||::|:|||||.||.||:||||
Zfish   196 KRINYVQLEIDFPNESIKLSGTAPTDLKDLPKRIPKDAARYHFFLYKHSHEGDYLESTVFIYSMP 260

  Fly   261 GYSCSVRERMMYSSCKAPFLDELAA-LGVEVVKKLEIDSGSELTEAFLQDELHPKKILHRPAFAK 324
            ||.||::|||:|||||.|.:|.:.. ||:|:.||||||:|.|||..|:.:|:|||:..|:.||||
Zfish   261 GYKCSIKERMLYSSCKNPLIDTVERNLGIEIAKKLEIDNGDELTSDFMYEEVHPKQHAHKQAFAK 325

  Fly   325 PKGPP-NRGAKRLTR 338
            ||||. .||.:|:||
Zfish   326 PKGPTGKRGGRRITR 340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
twf	NP_650338.1	ADF_Twf-N_like	4..142	CDD:200441	61/137 (45%)
twf	NP_650338.1	ADF_Twf-C_like	176..310	CDD:200440	66/134 (49%)
twf1b	NP_001002304.1	ADF_Twf-N_like	4..142	CDD:200441	61/137 (45%)
twf1b	NP_001002304.1	ADF_Twf-C_like	176..311	CDD:200440	66/134 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595754
Domainoid	1	1.000	143	1.000	Domainoid score	I4589
eggNOG	1	0.900	-	-		E1_KOG1747
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H48140
Inparanoid	1	1.050	362	1.000	Inparanoid score	I2151
OMA	1	1.010	-	-		QHG54608
OrthoDB	1	1.010	-	-		D1578109at2759
OrthoFinder	1	1.000	-	-		FOG0001842
OrthoInspector	1	1.000	-	-		otm26238
orthoMCL	1	0.900	-	-		OOG6_102985
Panther	1	1.100	-	-	O	PTHR13759
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1569
SonicParanoid	1	1.000	-	-		X134
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	16	15.840