DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment twf and twf1a

DIOPT Version :9

Sequence 1:	NP_650338.1	Gene:	twf / 41719	FlyBaseID:	FBgn0038206	Length:	343	Species:	Drosophila melanogaster
Sequence 2:	NP_956019.1	Gene:	twf1a / 325677	ZFINID:	ZDB-GENE-030131-4402	Length:	350	Species:	Danio rerio

Alignment Length:	340	Identity:	173/340 - (50%)
Similarity:	246/340 - (72%)	Gaps:	2/340 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSHQTGIRANEQLAKVFGKAKNGKFRVIKVSIENEQLSCGATAETKKDWERDYDKLIGPLLEKDV 65
            |||||||:|.:::..|||.|:||::|::|:.||||:|..|.|....:.||.|||.|:.|:||:|:
Zfish     1 MSHQTGIQAADEVKDVFGNARNGQYRLLKIVIENEELVLGLTKPASRSWEEDYDALLLPVLEQDL 65

  Fly    66 PCYILYRLDAKIPLGYSWLLISWTPDTASIRQKMVYASTKATLKTEFGSAYITEELHATTLDECT 130
            |||||:|||:...||:.|:.|:|:||.:.:|.||:||:|:||:|.|||..:|.:|:..|..|:.:
Zfish    66 PCYILFRLDSSNSLGHEWIFIAWSPDHSPVRHKMLYAATRATIKKEFGLGHIKDEMFGTVKDDVS 130

  Fly   131 LEGYRRHKQDFAAPAPLTSREEELKELRKTEVHTEINTNTRHQTLGGINCPLSEATVAAVQDLVR 195
            |.||::|....:||.|||:.||||::::.:||:|:|:.||..|||.|:..||....:.|:|....
Zfish   131 LSGYKKHVMAQSAPLPLTAAEEELRQIKLSEVNTDIHVNTTKQTLQGVAFPLDGEAMNALQKFKD 195

  Fly   196 GKHDYLQFRIDLEEEQIHVSRAAKVELADLPKQVPEDHARYHLFLFRHTHEGDYFESYVFVYSMP 260
            .|..|:|..|:.|:|.|.:|.....|:.||||::|:|.||||.|.|:|:|||||.||.||:||||
Zfish   196 KKLSYVQLMINFEKELIVLSSTESTEVKDLPKRIPKDAARYHFFRFKHSHEGDYLESAVFIYSMP 260

  Fly   261 GYSCSVRERMMYSSCKAPFLDEL-AALGVEVVKKLEIDSGSELTEAFLQDELHPKKILHRPAFAK 324
            ||||.:||||:|||||.|.||.: :.|.:||.||:|||:|.:||..||.||:|||:..|:.||||
Zfish   261 GYSCGIRERMLYSSCKNPLLDMVESKLQMEVEKKMEIDNGEDLTADFLYDEVHPKQHAHKQAFAK 325

  Fly   325 PKGPP-NRGAKRLTR 338
            |:||. .||.:|:||
Zfish   326 PRGPQGRRGERRITR 340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
twf	NP_650338.1	ADF_Twf-N_like	4..142	CDD:200441	65/137 (47%)
twf	NP_650338.1	ADF_Twf-C_like	176..310	CDD:200440	69/134 (51%)
twf1a	NP_956019.1	ADF_Twf-N_like	4..142	CDD:200441	65/137 (47%)
twf1a	NP_956019.1	ADF_Twf-C_like	176..311	CDD:200440	69/134 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	143	1.000	Domainoid score	I4589
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	362	1.000	Inparanoid score	I2151
OMA	1	1.010	-	-		QHG54608
OrthoDB	1	1.010	-	-		D1578109at2759
OrthoFinder	1	1.000	-	-		FOG0001842
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13759
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X134
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	10.080