DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment twf and twf2

DIOPT Version :9

Sequence 1:	NP_650338.1	Gene:	twf / 41719	FlyBaseID:	FBgn0038206	Length:	343	Species:	Drosophila melanogaster
Sequence 2:	XP_005166062.1	Gene:	twf2 / 100310784	-ID:	-	Length:	352	Species:	Danio rerio

Alignment Length:	340	Identity:	164/340 - (48%)
Similarity:	232/340 - (68%)	Gaps:	7/340 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 EQLAKVFGKAKNGKFRVIKVSIENEQLSCGATAETKKDWERDYDKLIGPLLEKDVPCYILYRLDA 75
            |:|.:...:|:||..|:|:|.|.:|||..||..|.:..|::|||.::.|||:...|||||||||:
Zfish     9 EELREFLARARNGTGRLIQVLIRDEQLVLGAYREPRHSWDKDYDPVLLPLLDPLEPCYILYRLDS 73

  Fly    76 KIPLGYSWLLISWTPDTASIRQKMVYASTKATLKTEFGSAYITEELHATTLDECTLEGYRRHKQD 140
            |...||.||.|||:||.:.:||||:||:|:||:|.|||..::.:|:..|..::..|:||.||...
Zfish    74 KNAQGYEWLFISWSPDQSPVRQKMLYAATRATVKKEFGGGHVKDEMFGTVEEDICLQGYLRHITS 138

  Fly   141 FAAPAPLTSREEELKELRKTE-----VHTEINTNTRHQTLGGINCPLSEATVAAVQDLVRGKHDY 200
            .:||||||..|:||:.::.||     |..||:.:.:||||.|:..||......|::.|...:.:|
Zfish   139 CSAPAPLTVAEQELQRIKITEGRVKQVKAEISVDPKHQTLQGLAFPLQAEAKRALKQLAERRINY 203

  Fly   201 LQFRIDLEEEQIHVSRAAKVELADLPKQVPEDHARYHLFLFRHTHEGDYFESYVFVYSMPGYSCS 265
            :|.::|.|:|.|.:...:..::.|||.::|.|..|||.||::|:|||||.||.||:|||||||||
Zfish   204 IQLKLDTEKETIDLVHTSPTDIRDLPCRIPLDTPRYHFFLYKHSHEGDYLESVVFIYSMPGYSCS 268

  Fly   266 VRERMMYSSCKAPFLDELAA-LGVEVVKKLEIDSGSELTEAFLQDELHPKKILHRPAFAKPKGPP 329
            ::|||:|||||:..|||:.. ..:||.||||||||.||||.:|.||:|||:..|:.|||||:||.
Zfish   269 IKERMLYSSCKSRLLDEVERDFHLEVAKKLEIDSGEELTEEYLYDEVHPKQHAHKQAFAKPRGPA 333

  Fly   330 -NRGAKRLTRPTAED 343
             .||.|||.:...|:
Zfish   334 GKRGNKRLIKGGGEN 348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
twf	NP_650338.1	ADF_Twf-N_like	4..142	CDD:200441	61/130 (47%)
twf	NP_650338.1	ADF_Twf-C_like	176..310	CDD:200440	66/134 (49%)
twf2	XP_005166062.1	ADF_Twf-N_like	5..140	CDD:200441	61/130 (47%)
twf2	XP_005166062.1	ADF_Twf-C_like	179..314	CDD:200440	66/134 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595751
Domainoid	1	1.000	143	1.000	Domainoid score	I4589
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	362	1.000	Inparanoid score	I2151
OMA	1	1.010	-	-		QHG54608
OrthoDB	1	1.010	-	-		D1578109at2759
OrthoFinder	1	1.000	-	-		FOG0001842
OrthoInspector	1	1.000	-	-		otm26238
orthoMCL	1	0.900	-	-		OOG6_102985
Panther	1	1.100	-	-	LDO	PTHR13759
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1569
SonicParanoid	1	1.000	-	-		X134
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.900