DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment twf and twf2

DIOPT Version :9

Sequence 1:	NP_650338.1	Gene:	twf / 41719	FlyBaseID:	FBgn0038206	Length:	343	Species:	Drosophila melanogaster
Sequence 2:	NP_001123417.1	Gene:	twf2 / 100170198	XenbaseID:	XB-GENE-5878659	Length:	349	Species:	Xenopus tropicalis

Alignment Length:	345	Identity:	171/345 - (49%)
Similarity:	239/345 - (69%)	Gaps:	2/345 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSHQTGIRANEQLAKVFGKAKNGKFRVIKVSIENEQLSCGATAETKKDWERDYDKLIGPLLEKDV 65
            |:|||||.|..:|...|.||:||..|:|||.||.|||..|:..|.|..|::|||.|:.|||::..
Frog     1 MAHQTGIHATPELKDFFAKARNGSIRLIKVIIEEEQLVLGSHKELKHAWDQDYDALVLPLLDESE 65

  Fly    66 PCYILYRLDAKIPLGYSWLLISWTPDTASIRQKMVYASTKATLKTEFGSAYITEELHATTLDECT 130
            |||||||||::...||.|:.:||:||.:.:|.||:||:|:||:|.|||..:|.:|:..|..::..
Frog    66 PCYILYRLDSQNAQGYEWIFLSWSPDHSPVRLKMLYAATRATVKKEFGGGHIKDEIFGTLKEDIA 130

  Fly   131 LEGYRRHKQDFAAPAPLTSREEELKELRKTEVHTEINTNTRHQTLGGINCPLSEATVAAVQDLVR 195
            |.||::|....|||||||:.|.||:|::..||.|||:..::.|||.|::.||......|:..|.:
Frog   131 LGGYKKHVSSCAAPAPLTAAERELQEIKINEVKTEISVESKQQTLQGLSFPLRPEAEGAILLLKQ 195

  Fly   196 GKHDYLQFRIDLEEEQIHVSRAAKVELADLPKQVPEDHARYHLFLFRHTHEGDYFESYVFVYSMP 260
            .|.:|:|.|:|||:|.:.:......||.|||.::|:|.||||.||::|:||||:.||.||:||||
Frog   196 KKINYIQLRLDLEKETVDLVHTKHTELKDLPGRIPQDTARYHFFLYKHSHEGDHLESVVFIYSMP 260

  Fly   261 GYSCSVRERMMYSSCKAPFLDELAA-LGVEVVKKLEIDSGSELTEAFLQDELHPKKILHRPAFAK 324
            ||.||::|||:|||||...||.:.. ..:|:|||:||:.|:|||:.||.||:|||:...:.||||
Frog   261 GYKCSIKERMLYSSCKNKLLDSVEQDFQLEIVKKIEIEDGAELTDEFLYDEVHPKQHAFKQAFAK 325

  Fly   325 PKGPP-NRGAKRLTRPTAED 343
            ||||. .||.|||.:...|:
Frog   326 PKGPAGKRGQKRLIKGPGEN 345

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
twf	NP_650338.1	ADF_Twf-N_like	4..142	CDD:200441	66/137 (48%)
twf	NP_650338.1	ADF_Twf-C_like	176..310	CDD:200440	65/134 (49%)
twf2	NP_001123417.1	ADF_Twf-N_like	4..142	CDD:200441	66/137 (48%)
twf2	NP_001123417.1	ADF_Twf-C_like	176..311	CDD:200440	65/134 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	141	1.000	Domainoid score	I4676
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	364	1.000	Inparanoid score	I2118
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1578109at2759
OrthoFinder	1	1.000	-	-		FOG0001842
OrthoInspector	1	1.000	-	-		otm49495
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X134
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060