DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Abi and abi2a

DIOPT Version :9

Sequence 1:	NP_001247091.1	Gene:	Abi / 41718	FlyBaseID:	FBgn0020510	Length:	477	Species:	Drosophila melanogaster
Sequence 2:	XP_009302787.1	Gene:	abi2a / 767646	ZFINID:	ZDB-GENE-060929-192	Length:	556	Species:	Danio rerio

Alignment Length:	576	Identity:	227/576 - (39%)
Similarity:	292/576 - (50%)	Gaps:	141/576 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 MDELASLIRTEIPDGRQSLRDSYTNLERVADYCEDTYYRADNKKAALEATKNYTTQSLASVAYQI 77
            |.||..|:..|||.||::|.||:|||:|||:|||..|.:|.:|..|||.||||||||||||||.|
Zfish     1 MAELQMLLEEEIPAGRRALLDSFTNLDRVAEYCESNYVQAPDKHVALEETKNYTTQSLASVAYLI 65

  Fly    78 NTLAYSYMQLLELQAQQLGEMESQMNHIAQTVHIHKEKVARREIGVLTANKVSSRQFKIVAPINP 142
            ||||.:.:|:|::||.||..|||.:|||:|||.||||||||||||:||.||.:||..||:||.||
Zfish    66 NTLANNVLQMLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSRTHKIIAPANP 130

  Fly   143 EKPIKYVRKPIDYSMLDEIGHGINSAQHSQVRQKHRGSSHGSVQSLLPPSVGPPPTTKPPTPPQM 207
            |:|::|:||||||||||:||||:......:|..::.     .:.|||..:   |||.|||:||
Zfish   131 ERPVRYIRKPIDYSMLDDIGHGVKWLLRFKVNTQNM-----KMGSLLRTT---PPTQKPPSPP-- 185

  Fly   208 SRAGNTGTLGKSVSNTGTLGKSSREYRTPPVVNPPQVPSHYAPN-----YPIGHPKRMSTASSTM 267
                        ::..||:|:.| .|||...|.||.||:.|.|:     .||.|...:.|||...
Zfish   186 ------------MAGKGTIGRHS-PYRTLEPVRPPVVPNDYVPSPTRNMVPILHQSPVRTASVNQ 237

  Fly   268 TTTTTGGGAAGNERAAGYSA-----------------LPMPPSQQIATHVNLPSA---------G 306
            ...|...|::|....:..|:                 .|.|||...|:..:.|||         .
Zfish   238 RNRTYSSGSSGGSHPSSRSSSRENSGSGSVGLPIAVPTPSPPSAFPASGASTPSAPTNSTQPSVN 302

  Fly   307 MMQSLPPPPPTTYDDRSSMPP------------APPS--PLTVSQHEMTEQSH--IG---MHTLG 352
            .....|..||.|....|..||            :|||  |||.::...|..::  .|   .:::.
Zfish   303 SSSLTPTQPPVTPTSNSESPPSHPDSSESSDKGSPPSQPPLTSAEASATSSTNPETGAPQFYSMN 367

  Fly   353 RNINRN--PNRNHFSLNFARP------------------------GSQSPPLP------------ 379
            |.:.|.  |:... ||.:.||                        .|.:||.|
Zfish   368 RPVPRQTAPSVGG-SLPYRRPPSLTGQTSMPPSQQNGGPYYNQSQASVAPPPPSVLQITPQLPLT 431

  Fly   380 -------------PPPPPEDEHQDFGRPRTSTGPQLA-------------PIVPEDQNLPGWVPK 418
                         |||.|..|...|...:....|...             |...||   |.|.|:
Zfish   432 GFVARVQETITDAPPPSPPSEEPMFDDTQNPAAPPEGYEEEESSVVEYSDPYAEED---PPWAPQ 493

  Fly   419 NFIEKVVAIYDYYADKDDELSFQESSVLYVLKKNDDGWWEGVMDGVTGLFPGNYVE 474
            .::|||||||||..||:|||||||.:::||:|||||||:||||.|.||||||||||
Zfish   494 TYLEKVVAIYDYVRDKEDELSFQEGAIIYVIKKNDDGWYEGVMSGTTGLFPGNYVE 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Abi	NP_001247091.1	Abi_HHR	105..168	CDD:400255	45/62 (73%)
Abi	NP_001247091.1	SH3_Abi	423..474	CDD:212760	39/50 (78%)
abi2a	XP_009302787.1	Abi_HHR	93..169	CDD:285106	46/80 (58%)
abi2a	XP_009302787.1	SH3_Abi2	495..555	CDD:212905	42/55 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	115	1.000	Domainoid score	I5964
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4209
Inparanoid	1	1.050	338	1.000	Inparanoid score	I2345
OMA	1	1.010	-	-		QHG46430
OrthoDB	1	1.010	-	-		D1478981at2759
OrthoFinder	1	1.000	-	-		FOG0001315
OrthoInspector	1	1.000	-	-		otm24479
orthoMCL	1	0.900	-	-		OOG6_107782
Panther	1	1.100	-	-	O	PTHR10460
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5876
SonicParanoid	1	1.000	-	-		X1741
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	14.010