Protein Alignment Abi and ABI3

DIOPT Version :10

• Sequence 1: NP_001247091.1
• Gene: Abi / 41718
• FlyBaseID: FBgn0020510
• Length: 477
• Species: Drosophila melanogaster
• Sequence 2: XP_005257486.1
• Gene: ABI3 / 51225
• HGNCID: 29859
• Length: 373
• Species: Homo sapiens
• Alignment Length: 479
• Identity: 165/479 - (34%)
• Similarity: 225/479 - (46%)
• Gaps: 124/479 - (25%)

  Fly    13 MDELASLIRTEIPDGRQSLRDSYTNLERVADYCEDTYYRADNKKAALEATKNYTTQSLASVAYQI 77
            |.||..|...|||.||::||.:::.|.||||||||.|.:|.:|:.|||.|..:|||:|||||||:
Human     1 MAELQQLQEFEIPTGREALRGNHSALLRVADYCEDNYVQATDKRKALEETMAFTTQALASVAYQV 65

  Fly    78 NTLAYSYMQLLELQAQQLGEMESQMNHIAQTVHIHKEKVARREIGVL-TANKVSSRQFKIVAPIN 141
            ..||...:::|:||...|.::|::::.:.|.|::|.|||||||||.| |..::...| |::||.|
Human    66 GNLAGHTLRMLDLQGAALRQVEARVSTLGQMVNMHMEKVARREIGTLATVQRLPPGQ-KVIAPEN 129

  Fly   142 PEKPIKYVRKPIDYSMLDEIGHGINSAQHSQVRQKHRGSSHGSVQSLLPPSVGPPPTTKPPTPPQ 206
            ......|.|:|:::..||:|||||..
Human   130 LPPLTPYCRRPLNFGCLDDIGHGIKD--------------------------------------- 155

  Fly   207 MSRAGNTGTLGKSVSNTGTLGKSSREYRTPP----VVNPPQVPSH-YAPNYPIGHPKRMSTASST 266
                     |...:|.||||.:.|.:....|    :..||::|.. :.|..|.|   |:|.|||.
Human   156 ---------LSTQLSRTGTLSRKSIKAPATPASATLGRPPRIPEPVHLPVVPDG---RLSAASSA 208

  Fly   267 MTTTTTGG--GAAGNERAAGYSALPMPPSQQIATHVNLPSAGMMQSLPPPPPTTYDDRSSMPP-- 327
            .:..:.|.  |..|.....|.:|.|.||         |||     ||.||||....:....||
Human   209 FSLASAGSAEGVGGAPTPKGQAAPPAPP---------LPS-----SLDPPPPPAAVEVFQRPPTL 259

  Fly   328 ---APPSPLTVSQHEMTEQSHIGMHTLGRNINRNPNRNHFSLNFARPGSQSPPLP---PPPPPED 386
               :||.|.                              |.|   .|..:..|||   |||||.|
Human   260 EELSPPPPA------------------------------FLL---FPQDEELPLPLDLPPPPPLD 291

  Fly   387 EHQDFGRPRTSTGPQLAPIVPEDQNLPGWVPKNFIEKVVAIYDYYADKDDELSFQESSVLYVLKK 451
             ..:.|.|....|     ..|::   |.|||.:::||||.:|.|.:.||:||||.|.:|:.|.::
Human   292 -GDELGLPPPPPG-----FGPDE---PSWVPASYLEKVVTLYPYTSQKDNELSFSEGTVICVTRR 347

  Fly   452 NDDGWWEGVMDGVTGLFPGNYVEP 475
            ..|||.|||....||.||||||||
Human   348 YSDGWCEGVSSEGTGFFPGNYVEP 371

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Abi	NP_001247091.1	Abi_HHR	105..168	CDD:462279	29/63 (46%)
		SH3_Abi	423..474	CDD:212760	27/50 (54%)
ABI3	XP_005257486.1	Abi_HHR	93..156	CDD:462279	29/111 (26%)
		SH3_Abi	319..370	CDD:212760	27/50 (54%)