DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Abi and Abi2

DIOPT Version :9

Sequence 1:	NP_001247091.1	Gene:	Abi / 41718	FlyBaseID:	FBgn0020510	Length:	477	Species:	Drosophila melanogaster
Sequence 2:	NP_001380627.1	Gene:	Abi2 / 286928	RGDID:	628771	Length:	474	Species:	Rattus norvegicus

Alignment Length:	525	Identity:	214/525 - (40%)
Similarity:	286/525 - (54%)	Gaps:	121/525 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 MDELASLIRTEIPDGRQSLRDSYTNLERVADYCEDTYYRADNKKAALEATKNYTTQSLASVAYQI 77
            |.||..|:..|||.||::|.||||||||||||||:.|.::.:|:.|||.||.|||||||||||.|
  Rat     1 MAELQMLLEEEIPGGRRALFDSYTNLERVADYCENNYIQSPDKQRALEETKAYTTQSLASVAYLI 65

  Fly    78 NTLAYSYMQLLELQAQQLGEMESQMNHIAQTVHIHKEKVARREIGVLTANKVSSRQFKIVAPINP 142
            ||||.:.:|:|::||.||..|||.:|||:|||.||||||||||||:||.||.:||..||:||.|.
  Rat    66 NTLANNVLQMLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSRTHKIIAPANL 130

  Fly   143 EKPIKYVRKPIDYSMLDEIGHGINSAQHSQVRQKHRGSSHGSVQSLLPPSVGPPPTTKPPTPPQM 207
            |:|::|:||||||::||:||||:            :.|:.......||.:.  |||.|||:||
  Rat   131 ERPVRYIRKPIDYTILDDIGHGV------------KVSTQNMKMGGLPRTT--PPTQKPPSPP-- 179

  Fly   208 SRAGNTGTLGKSVSNTGTLGKSSREYRTPPVVNPPQVPSHYAPNYPIGH-------PKRMSTASS 265
                        :|..||||:.| .|||...|.||.||:.|.|: |..:       |.|.::.:.
  Rat   180 ------------MSGKGTLGRHS-PYRTLEPVRPPVVPNDYVPS-PTRNMAPSQQSPVRTASVNQ 230

  Fly   266 TMTTTTTGGGAAGNERAAGYSALPMPPSQQIATHVNLPSAGMMQSLPPPPPTTYDDRS----SM- 325
            ...|.::.|.:.|:..::..|:.....|..:...:.:|:        |.||:.:....    ||
  Rat   231 RNRTYSSSGSSGGSHPSSRSSSRENSGSGSVGVPIAVPT--------PSPPSVFPGHPVQFYSMN 287

  Fly   326 -------PPA---------PPSPLTVSQHEMTEQSHIGMHTLGRNINRNPNRNHFSLNFARPGSQ 374
                   ||.         |||        :|.|:     :|...:|..|..|...::.|.|
  Rat   288 RPASRHTPPTIGGSLPYRRPPS--------ITSQT-----SLQNQMNGGPFYNQNPVSLAPP--- 336

  Fly   375 SPPL-----------------------PPPPPPEDE------------HQDFGRPRTSTGPQLAP 404
             ||:                       ||||||.||            .:|:.....:......|
  Rat   337 -PPILQVTPQLPLMGFVARVQENISDTPPPPPPVDEPVFDESPPPPPPPEDYEEEEAAVVEYSDP 400

  Fly   405 IVPEDQNLPGWVPKNFIEKVVAIYDYYADKDDELSFQESSVLYVLKKNDDGWWEGVMDGVTGLFP 469
            ...||   |.|.|::::|||||||||..||:|||||||.:::||:|||||||:||||:|||||||
  Rat   401 YAEED---PPWAPRSYLEKVVAIYDYTKDKEDELSFQEGAIIYVIKKNDDGWYEGVMNGVTGLFP 462

  Fly   470 GNYVE 474
            |||||
  Rat   463 GNYVE 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Abi	NP_001247091.1	Abi_HHR	105..168	CDD:400255	42/62 (68%)
Abi	NP_001247091.1	SH3_Abi	423..474	CDD:212760	40/50 (80%)
Abi2	NP_001380627.1	Abi_HHR	93..156	CDD:400255	42/74 (57%)
Abi2	NP_001380627.1	SH3_Abi2	413..473	CDD:212905	43/55 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	97	1.000	Domainoid score	I7080
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4209
Inparanoid	1	1.050	334	1.000	Inparanoid score	I2328
OMA	1	1.010	-	-		QHG46430
OrthoDB	1	1.010	-	-		D1478981at2759
OrthoFinder	1	1.000	-	-		FOG0001315
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_107782
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1741
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.880