DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Abi and abi-1

DIOPT Version :9

Sequence 1:	NP_001247091.1	Gene:	Abi / 41718	FlyBaseID:	FBgn0020510	Length:	477	Species:	Drosophila melanogaster
Sequence 2:	NP_498224.1	Gene:	abi-1 / 175789	WormBaseID:	WBGene00015146	Length:	469	Species:	Caenorhabditis elegans

Alignment Length:	535	Identity:	178/535 - (33%)
Similarity:	253/535 - (47%)	Gaps:	141/535 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 MDELASLIRTEIPDGRQSLRDSYTNLERVADYCEDTYYRADNKKAALEATKNYTTQSLASVAYQI 77
            :::|..||...|||.|..|..|:.||::||.||||.|.:::||.||||.:|.:..|:||||||||
Worm     3 VNDLQELIERRIPDNRAQLETSHANLQQVAAYCEDNYIQSNNKSAALEESKKFAIQALASVAYQI 67

  Fly    78 NTLAYSYMQLLELQAQQLGEMESQMNHIAQTVHIHKEKVARREIGVLTANKVSSRQFKIVAPINP 142
            |.:......:|.||..::..:.:|:.:::|.|.:||||:||||||.||.||...:|.||:||..|
Worm    68 NKMVTDLHDMLALQTDKVNSLTNQVQYVSQVVDVHKEKLARREIGSLTTNKTLFKQPKIIAPAIP 132

  Fly   143 EKPIKYVRKPIDYSMLDEIGHGINSAQHSQVRQKHRGSSHGSVQSLLPPSVGPPPTTKPPTPPQM 207
            ::..:|.|.|||:|:||.||||:.                               |:.||....:
Worm   133 DEKQRYQRTPIDFSVLDGIGHGVR-------------------------------TSDPPRAAPI 166

  Fly   208 SRAGNTGTLGKSVS---------------NTGTLGKSSR---------EYRTPPVVNPPQVPSHY 248
            ||| .:...|.|.|               .|.|||::.|         :||.|.|.  ||..|.
Worm   167 SRA-TSSISGSSPSQFHNESPAYGVYAGERTATLGRTMRPYAPSIAPSDYRLPQVT--PQSESR- 227

  Fly   249 APNYPIGHPKRMSTASSTMTTTTTGGGAAGNERAAGYSALPMPP---------SQQIATHVNLP- 303
                 ||  ::||..|......:.|||:.....::.|:::..|.         ...:....::|
Worm   228 -----IG--RQMSHGSEFGDHMSGGGGSGSQHGSSDYNSIYQPDRYGTIRAGGRTTVDGSFSIPR 285

  Fly   304 ------SAGMMQS--LPPPPP----TTYDDRSSMPPAPPSPLTVSQHEMTEQSHIGMHTLGRN-I 355
                  |||..:|  .|.|||    |.|       .||.|.:...|.:..:|.:.|  |:.:: :
Worm   286 LSSAQSSAGGPESPTFPLPPPAMNYTGY-------VAPGSVVQQQQQQQMQQQNYG--TIRKSTV 341

  Fly   356 NRNPNRNHFSLNFARPGSQSPPLPPPP-----------PPEDEHQDFGRPRTSTGPQLAPIV--- 406
            ||:                  .|||||           |.:|:..|...|..|.|...|..|
Worm   342 NRH------------------DLPPPPNSLLTGMSSRMPTQDDMDDLPPPPESVGGSSAYGVFAG 388

  Fly   407 ---------PED--QNLPGWVPKNFIEKVVAIYDYYADKDDELSFQESSVLYVLKKNDDGWWEGV 460
                     |..  ....||:|..::|||..:|||.|.|:|||:.:|::::||||||||.|:|||
Worm   389 RTESYSSSQPPSLFDTSAGWMPNEYLEKVRVLYDYDAAKEDELTLRENAIVYVLKKNDDDWYEGV 453

  Fly   461 MDGVTGLFPGNYVEP 475
            :||||||||||||.|
Worm   454 LDGVTGLFPGNYVVP 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Abi	NP_001247091.1	Abi_HHR	105..168	CDD:400255	34/62 (55%)
Abi	NP_001247091.1	SH3_Abi	423..474	CDD:212760	34/50 (68%)
abi-1	NP_498224.1	Abi_HHR	95..169	CDD:369536	38/104 (37%)
abi-1	NP_498224.1	SH3_Abi	416..466	CDD:212760	33/49 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165751
Domainoid	1	1.000	83	1.000	Domainoid score	I5348
eggNOG	1	0.900	-	-		E1_KOG2546
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	248	1.000	Inparanoid score	I2025
Isobase	1	0.950	-	0	Normalized mean entropy	S2978
OMA	1	1.010	-	-		QHG46430
OrthoDB	1	1.010	-	-		D1478981at2759
OrthoFinder	1	1.000	-	-		FOG0001315
OrthoInspector	1	1.000	-	-		oto19066
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10460
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5876
SonicParanoid	1	1.000	-	-		X1741
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.890