DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Abi and Abi1

DIOPT Version :9

Sequence 1:	NP_001247091.1	Gene:	Abi / 41718	FlyBaseID:	FBgn0020510	Length:	477	Species:	Drosophila melanogaster
Sequence 2:	NP_001070658.1	Gene:	Abi1 / 11308	MGIID:	104913	Length:	481	Species:	Mus musculus

Alignment Length:	537	Identity:	219/537 - (40%)
Similarity:	283/537 - (52%)	Gaps:	138/537 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 MDELASLIRTEIPDGRQSLRDSYTNLERVADYCEDTYYRADNKKAALEATKNYTTQSLASVAYQI 77
            |.||..|:..|||.|:::|.:||.||.|||||||:.|.:|.:|:.|||.||.|||||||||||||
Mouse     1 MAELQMLLEEEIPSGKRALIESYQNLTRVADYCENNYIQATDKRKALEETKAYTTQSLASVAYQI 65

  Fly    78 NTLAYSYMQLLELQAQQLGEMESQMNHIAQTVHIHKEKVARREIGVLTANKVSSRQFKIVAPINP 142
            |.||.:.:|||::||.||..|||.:|||:|||.||||||||||||:||.||.:||..||:||.|.
Mouse    66 NALANNVLQLLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSRTHKIIAPANM 130

  Fly   143 EKPIKYVRKPIDYSMLDEIGHGINSAQHSQVRQKHRGSSHGSVQSLLPPSVGP-----PPTTKPP 202
            |:|::|:||||||::||::|||:          |...:.||:.|   |...|.     |||.|||
Mouse   131 ERPVRYIRKPIDYTVLDDVGHGV----------KWLKAKHGNNQ---PARTGTLSRTNPPTQKPP 182

  Fly   203 TPPQMSRAGNTGTLGKSVSNTGTLGKSSREYRTPPVVNPPQVPSHYAPNYPIGHPKRMS------ 261
            :||              ||..||||::: .|:|...|.||.||:.|..:     |.|:.
Mouse   183 SPP--------------VSGRGTLGRNT-PYKTLEPVKPPTVPNDYMTS-----PARLGSQHSPG 227

  Fly   262 -TASSTMTTTTTGG--GAAGNERAAGYSALPMPPSQQIATHVNLPSAGMMQSLPPPPPTTYDDRS 323
             |||......|..|  |.:|:...:|.|::.:|        :.:|:        |.|||.
Mouse   228 RTASLNQRPRTHSGSSGGSGSRENSGSSSIGIP--------IAVPT--------PSPPTA----- 271

  Fly   324 SMPPAPPSPLTVSQH-EMTEQSHIGMH----------------------TLGRNINRNPNRNHFS 365
              .||.|.....||: .||.|  |..|                      :...::|..|..:..|
Mouse   272 --GPAAPGAAPGSQYGTMTRQ--ISRHNSTTSSTSSGGYRRTPSVAAQFSAQPHVNGGPLYSQNS 332

  Fly   366 LNFARPGSQSP----------------------PLPPPPPPEDE---HQDFGRPRTSTGPQLAPI 405
            ::.|.|....|                      |.||||||.|:   ..|...|     |...|:
Mouse   333 ISVAPPPPPMPQLTPQIPLTGFVARVQENIADSPTPPPPPPPDDIPMFDDSPPP-----PPPPPV 392

  Fly   406 VPEDQNL-------------PGWVPKNFIEKVVAIYDYYADKDDELSFQESSVLYVLKKNDDGWW 457
            ..||:..             |.|.|||:||||||||||..||||||||:|.:::||:|||||||:
Mouse   393 DYEDEEAAVVQYSDPYADGDPAWAPKNYIEKVVAIYDYTKDKDDELSFKEGAIIYVIKKNDDGWF 457

  Fly   458 EGVMDGVTGLFPGNYVE 474
            |||.:.|||||||||||
Mouse   458 EGVCNRVTGLFPGNYVE 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Abi	NP_001247091.1	Abi_HHR	105..168	CDD:400255	41/62 (66%)
Abi	NP_001247091.1	SH3_Abi	423..474	CDD:212760	38/50 (76%)
Abi1	NP_001070658.1	Required for binding to WASF1	18..79		39/60 (65%)
		Abi_HHR	93..169	CDD:285106	46/88 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	158..285		49/172 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	318..348		6/29 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	361..392		11/35 (31%)
		SH3_Abi1	423..481	CDD:212904	40/52 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	116	1.000	Domainoid score	I5941
eggNOG	1	0.900	-	-		E1_KOG2546
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	350	1.000	Inparanoid score	I2269
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46430
OrthoDB	1	1.010	-	-		D1478981at2759
OrthoFinder	1	1.000	-	-		FOG0001315
OrthoInspector	1	1.000	-	-		otm43082
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10460
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5876
SonicParanoid	1	1.000	-	-		X1741
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.970