Protein Alignment Abi and ABI1

DIOPT Version :9

• Sequence 1: NP_001247091.1
• Gene: Abi / 41718
• FlyBaseID: FBgn0020510
• Length: 477
• Species: Drosophila melanogaster
• Sequence 2: NP_005461.2
• Gene: ABI1 / 10006
• HGNCID: 11320
• Length: 508
• Species: Homo sapiens
• Alignment Length: 549
• Identity: 221/549 - (40%)
• Similarity: 287/549 - (52%)
• Gaps: 135/549 - (24%)

  Fly    13 MDELASLIRTEIPDGRQSLRDSYTNLERVADYCEDTYYRADNKKAALEATKNYTTQSLASVAYQI 77
            |.||..|:..|||.|:::|.:||.||.|||||||:.|.:|.:|:.|||.||.|||||||||||||
Human     1 MAELQMLLEEEIPSGKRALIESYQNLTRVADYCENNYIQATDKRKALEETKAYTTQSLASVAYQI 65

  Fly    78 NTLAYSYMQLLELQAQQLGEMESQMNHIAQTVHIHKEKVARREIGVLTANKVSSRQFKIVAPINP 142
            |.||.:.:|||::||.||..|||.:|||:|||.||||||||||||:||.||.:||..||:||.|.
Human    66 NALANNVLQLLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSRTHKIIAPANM 130

  Fly   143 EKPIKYVRKPIDYSMLDEIGHGINSAQHSQVRQKHRGSSHGSVQSLLPPSVGP-----PPTTKPP 202
            |:|::|:||||||::||::|||:          |...:.||:.|   |...|.     |||.|||
Human   131 ERPVRYIRKPIDYTVLDDVGHGV----------KWLKAKHGNNQ---PARTGTLSRTNPPTQKPP 182

  Fly   203 TPPQMSRAGNTGTLGKSVSNTGTLGKSSREYRTPPVVNPPQVPSHYAPNYPIGHPKRMS------ 261
            :||              :|..||||::: .|:|...|.||.||:.|..:     |.|:.
Human   183 SPP--------------MSGRGTLGRNT-PYKTLEPVKPPTVPNDYMTS-----PARLGSQHSPG 227

  Fly   262 -TASSTMTTTTTGG--GAAGNERAAGYSALPMPPSQQIATHVNLPSAGMMQSLPPPPPTTYDDRS 323
             |||......|..|  |.:|:...:|.|::.:|    ||.....|.....:::..|||      |
Human   228 RTASLNQRPRTHSGSSGGSGSRENSGSSSIGIP----IAVPTPSPPTIGPENISVPPP------S 282

  Fly   324 SMPPAPP-SPL-----------------------TVSQHEMTEQSH-----------IGMHTLGR 353
            ..||||| :||                       .:|:|..|..|.           ....:...
Human   283 GAPPAPPLAPLLPVSTVIAAPGSAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFSAQP 347

  Fly   354 NINRNPNRNHFSLNFARPGSQSP----------------------PLPPPPPPEDE---HQDFGR 393
            ::|..|..:..|::.|.|....|                      |.||||||.|:   ..|...
Human   348 HVNGGPLYSQNSISIAPPPPPMPQLTPQIPLTGFVARVQENIADSPTPPPPPPPDDIPMFDDSPP 412

  Fly   394 PRTSTGPQLAPIVPEDQNL-------------PGWVPKNFIEKVVAIYDYYADKDDELSFQESSV 445
            |     |...|:..||:..             |.|.|||:||||||||||..||||||||.|.::
Human   413 P-----PPPPPVDYEDEEAAVVQYNDPYADGDPAWAPKNYIEKVVAIYDYTKDKDDELSFMEGAI 472

  Fly   446 LYVLKKNDDGWWEGVMDGVTGLFPGNYVE 474
            :||:|||||||:|||.:.|||||||||||
Human   473 IYVIKKNDDGWYEGVCNRVTGLFPGNYVE 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Abi	NP_001247091.1	Abi_HHR	105..168	CDD:400255	41/62 (66%)
		SH3_Abi	423..474	CDD:212760	38/50 (76%)
ABI1	NP_005461.2	Required for binding to WASF1. /evidence=ECO:0000250	18..79		39/60 (65%)
		Abi_HHR	93..156	CDD:400255	42/72 (58%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	159..290		49/163 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	306..375		10/68 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	388..421		12/37 (32%)
		SH3_Abi1	450..508	CDD:212904	40/52 (77%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	116	1.000	Domainoid score	I5963
eggNOG	1	0.900	-	-		E1_KOG2546
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	341	1.000	Inparanoid score	I2360
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46430
OrthoDB	1	1.010	-	-		D1478981at2759
OrthoFinder	1	1.000	-	-		FOG0001315
OrthoInspector	1	1.000	-	-		otm41011
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10460
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5876
SonicParanoid	1	1.000	-	-		X1741
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.970