DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kif19A and KIP3

DIOPT Version :9

Sequence 1:	NP_996208.1	Gene:	Kif19A / 41717	FlyBaseID:	FBgn0038205	Length:	750	Species:	Drosophila melanogaster
Sequence 2:	NP_011299.1	Gene:	KIP3 / 852655	SGDID:	S000003184	Length:	805	Species:	Saccharomyces cerevisiae

Alignment Length:	806	Identity:	236/806 - (29%)
Similarity:	354/806 - (43%)	Gaps:	245/806 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ATSAGASSWSGSSGGSN-SSQGRSIATAQPAQEERLVVAVRVRPSMEATERCIEVISGGSLLYDD 65
            ||.|.|||.:.|:..:. |||.|.                                .||.:
Yeast   123 ATKATASSINNSNATNKFSSQRRR--------------------------------HGGEI---- 151

  Fly    66 GGKSRPRQYSYDHVFRENDSQEQVYKTTTAPLVRDVLNGLNAAVFAYGATGSGKTHTMLGPVPRK 130
                   ::.:|.:|.|..||.:|||.||:||:..||:|.|:.||||||||.|||:|:.|
Yeast   152 -------KFVFDKLFDETSSQARVYKETTSPLLDSVLDGFNSTVFAYGATGCGKTYTVSG----- 204

  Fly   131 KPQTSDRAPPTASCDSTDVSSQDIGLMVRAIEDIFSHI-ESAEAYSCRVSISYLEIYNELIRDLL 194
                              ..||. |::..|:|::|:.| :..:.....:|:||||||||.|||||
Yeast   205 ------------------TPSQP-GIIFLAMEELFNKITDLKDEKDFEISLSYLEIYNERIRDLL 250

  Fly   195 NPGGP---LELREDHRGQRITVAGLSEITTSSRKEVVSLLLKGNKARTMEPTAANQTSSRSHALL 256
            .|..|   |.:|||.: ..|.||.||....::.::|:.|:::||..||..||.||:.||||||:|
Yeast   251 KPETPSKRLVIREDTQ-NHIKVANLSYHHPNTVEDVMDLVVQGNINRTTSPTEANEVSSRSHAVL 314

  Fly   257 SIMVQARTPLG--TKQ---GRLFLTDLAGSERAKKTKNRGKRLQEGAHINRSLLALGNVING--L 314
            .|.:.....|.  |.|   ..|.:.||||||||..|:|||.||.|||:||||||||||.||.  |
Yeast   315 QIHIMQTNKLVDLTSQHTFATLSIIDLAGSERAAATRNRGIRLHEGANINRSLLALGNCINALCL 379

  Fly   315 SGGAR--YVNYRDSKLTRLLKEALSGRCKTVMIAHVAPESKHRDETKNTLVYADRANSITTKL-- 375
            :.|:|  ::.|||||||||||.:|.|.||||||..::|.|.|.|||.|||.||:||..|.||:
Yeast   380 NDGSRSCHIPYRDSKLTRLLKFSLGGNCKTVMIVCISPSSSHYDETLNTLKYANRAKEIKTKIIR 444

  Fly   376 -QNSVYIDEFKDFPTKHYQSLVSELRDEVSRLRTKMLTERPRSGAAAAAAAAAASGSAGTAGSGA 439
             |.|:         ::|..|.:            ||:||:.|.
Yeast   445 NQQSL---------SRHVGSYL------------KMITEQKRQ---------------------- 466

  Fly   440 GSEAVQEQDEQ----RKTELRYLREQIVL-----------------------TFKQQMKLRRKLL 477
             .|.::|::|:    :.|:.:..:|:|.|                       |.|..:..:|:.|
Yeast   467 -IEELREREEKMISLKLTKYKLNKEKIQLAINECVNRVQQTYAGVETYQVAKTLKSLILCKRRFL 530

  Fly   478 EAESHLLGLELD------------AERQHMIISHWQGRIGKLYDAMGDDDIESEGSVALKNAWGE 530
            :    ::.||:|            |.....:||:.:...|:||:.:.:.:::.:.:..|.:...:
Yeast   531 Q----MVKLEVDNLILLFEREESTAAEMQPVISNCRMISGQLYNKIHELEMKFDETDTLSSVIHQ 591

  Fly   531 LAAIEKETRRYKEIRERTEHELEQCRQKGVKLEDELPERISSDEERELLAL---LCRVHELEADK 592
            :.:|:     ..::||               :||       .||..:|:.|   |.::.||:.::
Yeast   592 VHSID-----LNKLRE---------------MED-------WDETYDLVYLESCLNQISELQRNE 629

  Fly   593 V----SLQAERLARQAELRRRDLQLLRAERQRRL--CEDIISSQRRLIEEGNVDLPDELRELYGL 651
            :    |:..|:|.....|..| .:.|......|.  .|.||.....:.||
Yeast   630 ILVNSSIMTEKLMSDPGLNSR-FKFLSKWLMNRTPNIESIIQDLVHIDEE--------------- 678

  Fly   652 YQQEIHAGVVTPSTSNYERKLPPIYTAGSD--SPG--------SSSSSEW-SP-ASPLPQIDNQM 704
            ::......:..|.::.....:..|.|..:|  .|.        |....:| || .||.|.|:.|
Yeast   679 FESFARTFIANPDSNFTNTNINIINTTAADLAVPAETLQRQNFSQKKVKWTSPDLSPSPMIEPQ- 742

  Fly   705 DPVDRVMGPPVNPRLPRLSAATSANV 730
                    |.:.|.|.:...|.::.|
Yeast   743 --------PELEPELHQDQDAIASEV 760

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kif19A	NP_996208.1	Motor_domain	35..371	CDD:277568	149/348 (43%)
Kif19A	NP_996208.1	Kinesin	41..371	CDD:278646	149/342 (44%)
KIP3	NP_011299.1	KISc_KIP3_like	82..438	CDD:276821	160/382 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0242
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000448
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100835
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R640
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.740