DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kif19A and AT3G49650

DIOPT Version :9

Sequence 1:	NP_996208.1	Gene:	Kif19A / 41717	FlyBaseID:	FBgn0038205	Length:	750	Species:	Drosophila melanogaster
Sequence 2:	NP_190534.1	Gene:	AT3G49650 / 824127	AraportID:	AT3G49650	Length:	813	Species:	Arabidopsis thaliana

Alignment Length:	780	Identity:	232/780 - (29%)
Similarity:	345/780 - (44%)	Gaps:	172/780 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 SIATAQPAQEERLVVAVRVRPSMEATERCIEVI----SGGSLLYDDG----------GKSRPRQY 74
            ||......:...|.|||:.||.|| .||..:::    |...::.|..          .:::.::|
plant     3 SIRAPAAKKTTTLTVAVKCRPLME-KERGRDIVRVNNSKEVVVLDPDLSKDYLDRIQNRTKEKKY 66

  Fly    75 SYDHVFRENDSQEQVYKTTTAPLVRDVLNGLNAAVFAYGATGSGKTHTMLGPVPRKKPQTSDRAP 139
            .:||.|....:.:.||::.:: ::..|::||||.|||||:||||||:||:|
plant    67 CFDHAFGPESTNKNVYRSMSS-VISSVVHGLNATVFAYGSTGSGKTYTMVG-------------- 116

  Fly   140 PTASCDSTDVSSQDIGLMVRAIEDIFSHIESAEAY-SCRVSISYLEIYNELIRDLL-NPGGPLEL 202
                      :..|.||||.::..||..|:|.::. ...|:.||||:|||:|.||| ...|.|||
plant   117 ----------TRSDPGLMVLSLNTIFDMIKSDKSSDEFEVTCSYLEVYNEVIYDLLEKSSGHLEL 171

  Fly   203 REDHRGQRITVAGLSEITTSSRKEVVSLLLKGNKARTMEPTAANQTSSRSHALLSIMVQARTPLG 267
            |||.. |.|.||||..|...|...::.||..||..|..|.|..|.|||||||:|.|.|:.|....
plant   172 REDPE-QGIVVAGLRSIKVHSADRILELLNLGNSRRKTESTEMNGTSSRSHAVLEIAVKRRQKNQ 235

  Fly   268 TK--QGRLFLTDLAGSERAKKTKNRGKRLQEGAHINRSLLALGNVINGL----SGGARYVNYRDS 326
            .:  :|:|.|.||||||||.:|.|.|::|::||:||||||||.|.||.|    ..|..||.||:|
plant   236 NQVMRGKLALVDLAGSERAAETNNGGQKLRDGANINRSLLALANCINALGKQHKKGLAYVPYRNS 300

  Fly   327 KLTRLLKEALSGRCKTVMIAHVAPESKHRDETKNTLVYADRANSITTKLQNSV-YIDEFKDFPTK 390
            ||||:||:.|||..:|||:|.::|.......|.|||.|||||..|.|.:|.:: .||..    ..
plant   301 KLTRILKDGLSGNSQTVMVATISPADSQYHHTVNTLKYADRAKEIKTHIQKNIGTIDTH----MS 361

  Fly   391 HYQSLVSELRDEVSRLRTKMLTERPRSGAAAAAAAAAASGSAGTAGSGAGSEAVQEQDEQRKTEL 455
            .||.::..|:.|||:|:|::..:.                      |....:..:...|:..:.|
plant   362 DYQRMIDNLQSEVSQLKTQLAEKE----------------------SQLSIKPFERGVERELSWL 404

  Fly   456 RYLREQIVLTFKQQMKLRRKLLEAESHLLGLELDAERQHM------------IISHWQGRIGKLY 508
            ..|..||....:.::.|::.|.|.|.  ..|....|.||:            ::.....|...:.
plant   405 DGLSHQISENVQDRINLQKALFELEE--TNLRNRTELQHLDDAIAKQATEKDVVEALSSRRQVIL 467

  Fly   509 DAMGDDDIESEGSVALKNAWGELAAIEKETRRYKEIRERTEHELEQCRQKGVKLEDELPERISSD 573
            |.:.|:|                   |......::|.|..:|..|        |:|.|.|.|:::
plant   468 DNIRDND-------------------EAGVNYQRDIEENEKHRCE--------LQDMLNEAINNN 505

  Fly   574 EERELLALLCRVHELEADKVSLQAERLARQAELRRRDLQLLRAERQRRLCEDIISSQRRL----- 633
            ..:..|.:|.:...|......||.|...|.        |::..:|:         :||.|
plant   506 GNKTYLHILNQYKLLGMGNTELQFEMAMRD--------QIIYNQRE---------AQRNLWNLLM 553

  Fly   634 ---IEEGNVDLPDELRELYGLYQQEIHAGVVTPSTSNYERKLPPIYTAGSDSPG----------- 684
               :||..|   .:|....|:..::..:..:.|... |.::.|....|.....|
plant   554 GLGVEEKQV---FDLAAKQGITIEDWSSIALFPGLP-YRKQTPSFIPANIPFVGHSYSKSSCTFQ 614

  Fly   685 -----SSSSSEWSPASPLPQIDNQMDPVDRVMGPP--VNPRLPRLSAATSANVPAGGSRRPSLRV 742
                 ||...:|:|...|.:.::..........||  ||.|       .|.:...||| ||:.|:
plant   615 SYQDPSSKGQQWAPTPTLCREEHHSSYYFMRQEPPAFVNLR-------KSHDGWVGGS-RPASRI 671

Fly 743 742
plant 672 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kif19A	NP_996208.1	Motor_domain	35..371	CDD:277568	150/357 (42%)
Kif19A	NP_996208.1	Kinesin	41..371	CDD:278646	146/351 (42%)
AT3G49650	NP_190534.1	KISc_KIP3_like	14..345	CDD:276821	150/357 (42%)
		Kinesin	21..345	CDD:278646	146/350 (42%)
		FAM76	<355..437	CDD:292665	21/109 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0242
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000448
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100835
Panther	1	1.100	-	-	LDO	PTHR24115
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3746
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.770