DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kif19A and si:dkey-26i13.8

DIOPT Version :9

Sequence 1:	NP_996208.1	Gene:	Kif19A / 41717	FlyBaseID:	FBgn0038205	Length:	750	Species:	Drosophila melanogaster
Sequence 2:	XP_001337836.4	Gene:	si:dkey-26i13.8 / 797363	ZFINID:	ZDB-GENE-090312-134	Length:	991	Species:	Danio rerio

Alignment Length:	734	Identity:	278/734 - (37%)
Similarity:	409/734 - (55%)	Gaps:	111/734 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 EERLVVAVRVRPSMEATERCIEVISGGSL-----------LYDD---------GGKSRPRQYSYD 77
            :.:|.||:|:||..||     |:..|.::           |.|.         ..:||.:.|.:|
Zfish    10 DHQLTVALRIRPLNEA-----EIEEGATIVAHKIDNQMVVLMDPCEDSDNVLRAHRSREKTYMFD 69

  Fly    78 HVFRENDSQEQVYKTTTAPLVRDVLNGLNAAVFAYGATGSGKTHTMLGPVPRKKPQTSDRAPPTA 142
            ..|....:||.||..||..|:..|:.|.||.|||||.||:||||||||         .|..|
Zfish    70 LAFDYTATQEDVYVATTKNLIDGVIAGYNATVFAYGPTGAGKTHTMLG---------LDSEP--- 122

  Fly   143 SCDSTDVSSQDIGLMVRAIEDIFSHIE-SAEAYSCRVSISYLEIYNELIRDLLNP-GGPLELRED 205
                        |:.:|.:.|:|..|| |.|...|.|.:||:|||||:||||||| .|.||||||
Zfish   123 ------------GIYIRTLNDLFRAIEDSTEDLDCSVYMSYIEIYNEMIRDLLNPSSGYLELRED 175

  Fly   206 HRGQRITVAGLSEITTSSRKEVVSLLLKGNKARTMEPTAANQTSSRSHALLSIMVQARTPL---- 266
            .:|: |.:||::|.:|.:.||:::||.||||.||.|.||||:|||||||:|.:.|:.::.:
Zfish   176 GKGE-IRIAGITEFSTCNAKEIMALLTKGNKQRTQESTAANKTSSRSHAILQVTVKQKSRVKDIN 239

  Fly   267 -GTKQGRLFLTDLAGSERAKKTKNRGKRLQEGAHINRSLLALGNVINGLS----GGARYVNYRDS 326
             ..:.|:||:.||||:|||.:|:|||||::||||||||||||.|.||.||    .||::||||||
Zfish   240 EEVRVGKLFMVDLAGTERASQTQNRGKRMKEGAHINRSLLALANCINALSEKGGKGAQFVNYRDS 304

  Fly   327 KLTRLLKEALSGRCKTVMIAHVAPESKHRDETKNTLVYADRANSITTKLQNSVYIDEFKDFPTKH 391
            |||||||:||.|..:||||.|::|.|.:.:|::|||||||:|.:|.||::.::.   ...:....
Zfish   305 KLTRLLKDALGGNSRTVMITHISPASSNFEESRNTLVYADKAKNIRTKVKRNLM---NVSYHLAQ 366

  Fly   392 YQSLVSELRDEVSRLRTKMLTERPRSGAAAAAAAAAASGSAGTAGSGAGSEAVQEQDEQ-RKTEL 455
            |..::::||.|:.|||.|:                .........|..|....:|.:.:| ...|:
Zfish   367 YTRIIADLRSEIERLRAKI----------------DQQSQDQLKGEKADIRNIQAEVQQYSHGEM 415

  Fly   456 RYLREQIVLTFKQQMKLRRKLLEAESHLLGLELDAERQHMIISHWQ---GRIGKLYDAMG----- 512
            ..|:||::..|::||::||.|:|.|:..:.|.:|..|..:.||.|:   .|..:..|.:.
Zfish   416 ALLQEQLLSAFREQMEIRRSLMELENCNMELHIDTSRHLLTISDWERDRARARREKDELSGQKKH 480

  Fly   513 -DDDIESEGS-------VALKNAWGELAAIEKETRRYKEIRERTEHELEQCRQKGVKLEDELPER 569
             |.:.|.|..       .|.:...|.|.|   |.|:..|::...|.:|...:.|..|:|:.||:|
Zfish   481 TDKEEEQESMPEEPQYVTAAREEIGPLLA---EQRKTMELKRELEEKLLNMKLKSSKIEELLPKR 542

  Fly   570 ISSDEERELLALLCRVHELEADKVSLQAERLARQAELRRRDLQLLRAERQRRLCEDIISSQRRLI 634
            ||:.|:|::|.|||:|||||.:|..:|:..|.::..||.:|..:.|.|:||.||:|||..|:.||
Zfish   543 ISNTEQRDILMLLCKVHELELEKTEIQSAVLCKENVLRTKDFIIQRHEQQRTLCDDIIHQQKMLI 607

  Fly   635 EEGNVDLPDELRELYGLYQQEIHAGVV-------TPSTSNY---ERKLPPIYTAGSDSPGSSSSS 689
            |:..:.:|:.|:|||.||..|:..|::       |.:|:|.   :.:|..|...........|:.
Zfish   608 EDQGLCVPEGLQELYSLYFGELSDGIIDQILNLHTFTTNNLNARQLRLDVISNLEEADKAEQSNV 672

  Fly   690 EWSPASPLPQIDNQMDPVD 708
            ::||....|: |:....:|
Zfish   673 KFSPLDKHPR-DSSSSGLD 690

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kif19A	NP_996208.1	Motor_domain	35..371	CDD:277568	173/366 (47%)
Kif19A	NP_996208.1	Kinesin	41..371	CDD:278646	170/360 (47%)
si:dkey-26i13.8	XP_001337836.4	KISc	12..356	CDD:214526	176/373 (47%)
si:dkey-26i13.8	XP_001337836.4	KISc_KIP3_like	12..349	CDD:276821	173/366 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	288	1.000	Domainoid score	I1537
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	421	1.000	Inparanoid score	I1764
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D229434at33208
OrthoFinder	1	1.000	-	-		FOG0000448
OrthoInspector	1	1.000	-	-		otm25665
orthoMCL	1	0.900	-	-		OOG6_100835
Panther	1	1.100	-	-	LDO	PTHR24115
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R640
SonicParanoid	1	1.000	-	-		X3746
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	11.000