DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kif19A and kif22

DIOPT Version :9

Sequence 1:	NP_996208.1	Gene:	Kif19A / 41717	FlyBaseID:	FBgn0038205	Length:	750	Species:	Drosophila melanogaster
Sequence 2:	NP_001107063.1	Gene:	kif22 / 561788	ZFINID:	ZDB-GENE-080204-34	Length:	634	Species:	Danio rerio

Alignment Length:	710	Identity:	193/710 - (27%)
Similarity:	315/710 - (44%)	Gaps:	148/710 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 GSSGGSNSSQGRSIATAQPAQEERLVVAVRVRPSMEATER-----CIEVISGGSL-LYDDGGKSR 70
            |::|...:|              |:.||||:||.|:..:.     |:..:....| :.:....:.
Zfish    10 GAAGSKRTS--------------RVRVAVRLRPYMDKQDEKSEGSCVRGLGPQKLEIINWRNATE 60

  Fly    71 PRQYSYDHVFRENDSQEQVYKTTTAPLVRDVLNGLNAAVFAYGATGSGKTHTMLGPVPRKKPQTS 135
            ..||.:|....|..:|::|:.|:..|::..:|||.||:|||||.||:||||||||
Zfish    61 TLQYQFDVFHGEETTQQEVFLTSVKPILPHILNGQNASVFAYGPTGAGKTHTMLG---------- 115

  Fly   136 DRAPPTASCDSTDVSSQDIGLMVRAIEDIFSHI----ESAEAYSCRVSISYLEIYNELIRDLLNP 196
                          |.:..|::.||::::|:.:    :..:.:...:.:||||||||.:.|||:|
Zfish   116 --------------SQEQPGVIPRAVKEVFNLVGAQKKEQDGWEYSIGMSYLEIYNEKVLDLLSP 166

  Fly   197 GG-PLELREDHRGQRITVAGLSEITTSSRKEVVSLLLKGNKARTMEPTAANQTSSRSHALLSIMV 260
            |. .|.:||| :.:.|.:.||:....||..:..:..:..:..||...|..||.||||||:|.|.|
Zfish   167 GSQDLPIRED-KDRNILIPGLTHTPLSSFADFDTHFIPASLNRTTASTKLNQRSSRSHAILLIKV 230

  Fly   261 ---QARTPLGTKQGRLFLTDLAGSERAKKTKNRGKRLQEGAHINRSLLALGNVINGLSGGA-RYV 321
               |...|...:.|:|:|.||||||..::|.|:|.||:|...||.||..|..|::.|:.|| ..|
Zfish   231 VKSQRGPPHRQQTGKLYLVDLAGSEDNRRTGNQGIRLKESGAINLSLFTLSKVVDALNTGAGGRV 295

  Fly   322 NYRDSKLTRLLKEALSGRCKTVMIAHVAPESKHRDETKNTLVYADRANSITTKLQNSVYIDEFKD 386
            .||||||||||:::|.|...:|||.::|||.|:..:|.:.|.:|.::..|.    |..::.|...
Zfish   296 PYRDSKLTRLLQDSLGGSAHSVMITNIAPEYKYYFDTFSALNFAAKSKQIV----NRPFVRETVL 356

  Fly   387 FPTKHYQSLVSELRDEVSRLRTKMLTERPRSGAAAAAAAAAASGSAGTAGSGAGSEAVQEQDEQR 451
            .||            .....||:...|            |..||......|..|.:|  |.....
Zfish   357 APT------------IAPGKRTREEQE------------AGGSGEPQNKRSKEGKKA--EHSPSP 395

  Fly   452 KTELRYLREQIVLTFKQQMKLRRKLLEAESHLLGLELDAERQHMIISHWQGRIGKLYDAMGDDDI 516
            ....:...:..||.         :||..|..::|   .|||:.:.:.....:..|....:.:...
Zfish   396 PLHPQSSPDSSVLD---------RLLALEKMMMG---SAERERLNLLKTVAQSRKEIQMLKEKQK 448

  Fly   517 ESEGSVALKNAWGELAAIEKETRRYKEIRE----RTE----HELEQCRQKGVKLEDEL-PERISS 572
            |.|....:.|.       :|||.. ||.::    :|:    |..:....|..|.:..: |.::|.
Zfish   449 ELEDKANMFNK-------QKETTE-KESKDALLFKTDLPPLHRKQSTAAKPRKQQAVVTPLQVSQ 505

  Fly   573 DEERELLALLCRVHELEADKVSLQAE----------------------RL--ARQAELRRRDLQL 613
            .:..:..|::|:..:....|..:|.|                      ||  |...:.|::.||.
Zfish   506 VQPLQQCAVVCKPSQTLVKKKRVQTEVCDGKENIGVDLPPVEDVNWESRLDPALLEQSRKKILQT 570

  Fly   614 LRAERQRRL--CEDIISSQRRLI---EEGNVDLP--DELRELYGL----YQQEIHAGVVT 662
            |.:...:.|  .:.|...:.:||   .|.|.|..  ::|:::.|:    :...|.|.:::
Zfish   571 LNSGSLKELKSLQQIGDKKAKLIMGWREINGDFTQVEDLKKIEGVTVKRFSSFIKANILS 630

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kif19A	NP_996208.1	Motor_domain	35..371	CDD:277568	128/350 (37%)
Kif19A	NP_996208.1	Kinesin	41..371	CDD:278646	124/344 (36%)
kif22	NP_001107063.1	KISc	19..351	CDD:214526	130/360 (36%)
		KISc_KID_like	19..343	CDD:276827	128/348 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	357..406		12/74 (16%)
		HHH_3	571..620	CDD:289597	10/48 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000448
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910