Protein Alignment Kif19A and kif18a

DIOPT Version :10

• Sequence 1: NP_996208.1
• Gene: Kif19A / 41717
• FlyBaseID: FBgn0038205
• Length: 750
• Species: Drosophila melanogaster
• Sequence 2: NP_001016245.2
• Gene: kif18a / 548999
• XenbaseID: XB-GENE-990470
• Length: 947
• Species: Xenopus tropicalis
• Alignment Length: 670
• Identity: 204/670 - (30%)
• Similarity: 319/670 - (47%)
• Gaps: 123/670 - (18%)

  Fly    38 VAVRVRPSMEATE-----RCIEVISGGSLLYD----DGG---------------KSRPRQYSYDH 78
            |.|||||..|..:     |.::|:....|::|    :.|               |::..::.:|.
 Frog    14 VVVRVRPENEKEKQGNFSRVVQVVDNHILVFDPKVEEVGFFHGRSAANRDITKRKNKDLKFVFDC 78

  Fly    79 VFRENDSQEQVYKTTTAPLVRDVLNGLNAAVFAYGATGSGKTHTMLGPVPRKKPQTSDRAPPTAS 143
            ||.::.:|.:|::.||..::..||||.|..|.||||||:||||||||
 Frog    79 VFDDSSTQLEVFEQTTKIVLEGVLNGYNCTVLAYGATGAGKTHTMLG------------------ 125

  Fly   144 CDSTDVSSQDIGLMVRAIEDIFSHIESA-EAYSCRVSISYLEIYNELIRDLLNPGGPLELREDHR 207
                  |..:.|:|...:.::::.|||. :...|.|:|||||:|.|.|||||:..|.|.:|||.:
 Frog   126 ------SPGEPGVMYLTMMELYNRIESVKDEKVCNVAISYLEVYIEQIRDLLSNSGALAVREDAQ 184

  Fly   208 GQRITVAGLSEITTSSRKEVVSLLLKGNKARTMEPTAANQTSSRSHALLSIMVQ-----ARTPLG 267
             :.:.|.||:.....|.:|::.:|..|||.||..||..|.:||||||:..|.::     |.....
 Frog   185 -KGVVVQGLTLHQPKSAEEILQMLDYGNKNRTQHPTDMNASSSRSHAVFQIYLRQQDKTASINQN 248

  Fly   268 TKQGRLFLTDLAGSERAKKTKNRGKRLQEGAHINRSLLALGNVINGLS---GGARYVNYRDSKLT 329
            .:..::.|.||||||||..|..:|:||:||.:|||||||||||||.|:   ...:::.||:||||
 Frog   249 VRIAKMCLIDLAGSERASATNAKGERLREGTNINRSLLALGNVINALADPKSKKQHIPYRNSKLT 313

  Fly   330 RLLKEALSGRCKTVMIAHVAPESKHRDETKNTLVYADRANSITTKLQNSVYIDEFKDFPTKHYQS 394
            ||||::|.|.|:|:|||.|:|.|...|:|.|||.||:||..|.:.::::|.   ..|.....|..
 Frog   314 RLLKDSLGGNCRTIMIAAVSPSSLSYDDTYNTLKYANRAKDIKSAVKSNVV---SLDSHISQYVK 375

  Fly   395 LVSELRDEVSRLRTKMLTERPRSGAAAAAAAAAASGSAGTAGSGAGSEAVQEQDEQRKTELRYLR 459
            :..:.:.|::.|:.|:.....:...|                .|...:.|.....|.:.|::..:
 Frog   376 ICEQQKKEIAALKEKLKAYEDQKAIA----------------PGKPKQNVLLPPCQNQAEIKRFQ 424

  Fly   460 EQIVLTFKQQMKLRRKLLEAESHLLGLELDA-------ERQHMIISHWQGRIGKLYDAMGDDDIE 517
            |.:...|..:.::|.:.|..|......||..       |:..|:.|  |.:..|. ....|..:|
 Frog   425 EILRCLFTNREEIRAEYLNLEMRFKENELKTYYQKQCFEQIQMLCS--QEKAVKA-SCKRDHRVE 486

  Fly   518 SEGSVALKNAWGELAAIEKETRRYKEIRERTE--HELEQCRQKGVKLEDELPERISSDEERELLA 580
                 .|||.  .:...:|:....|.:.|.|.  |.||. ..|.:..:.::||.:..|
 Frog   487 -----VLKNQ--NVLLQKKKEDELKRLEENTTWLHRLES-EMKLLNNDGKMPEELGKD------- 536

  Fly   581 LLCRVHELEADKVSLQAERLARQAELRRRDLQLLRAERQRRLCEDII-----SSQRRLIEEGNVD 640
            |.|....||...:..|.:.:.|...|:         ||:.|..|.::     |.:|:.:....|.
 Frog   537 LQCHHLTLEVTDLKTQIKHMTRLVALQ---------ERENRYNEKLVNALLPSLRRQYLLLSQVG 592

  Fly   641 LPD-----ELRELYGLYQQE 655
            |.|     :.:::..|.|:|
 Frog   593 LADTCVEADFKKIEQLVQRE 612

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kif19A	NP_996208.1	Motor_domain	35..371	CDD:473979	145/365 (40%)
		SMC_prok_B	<393..672	CDD:274008	55/282 (20%)
kif18a	NP_001016245.2	KISc_KIP3_like	20..355	CDD:276821	140/359 (39%)