DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kif19A and Klp67A

DIOPT Version :9

Sequence 1:	NP_996208.1	Gene:	Kif19A / 41717	FlyBaseID:	FBgn0038205	Length:	750	Species:	Drosophila melanogaster
Sequence 2:	NP_001286999.1	Gene:	Klp67A / 39068	FlyBaseID:	FBgn0004379	Length:	814	Species:	Drosophila melanogaster

Alignment Length:	771	Identity:	227/771 - (29%)
Similarity:	341/771 - (44%)	Gaps:	190/771 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 QEERLVVAVRVRP----SMEATER-CIEVISGGSLLYD----------DGGKSRPRQYS------ 75
            |...:.|||||||    .:|..:| .|:|:...:||:|          .|.|...|..:
  Fly     5 QHTNIKVAVRVRPYNVRELEQKQRSIIKVMDRSALLFDPDEEDDEFFFQGAKQPYRDITKRMNKK 69

  Fly    76 ----YDHVFRENDSQEQVYKTTTAPLVRDVLNGLNAAVFAYGATGSGKTHTMLGPVPRKKPQTSD 136
                :|.||..::|.:.:::..|||||..||||.|.:||.|||||:|||.||||         |:
  Fly    70 LTMEFDRVFDIDNSNQDLFEECTAPLVDAVLNGYNCSVFVYGATGAGKTFTMLG---------SE 125

  Fly   137 RAPPTASCDSTDVSSQDIGLMVRAIEDIFSHIES-AEAYSCRVSISYLEIYNELIRDLLNPGGPL 200
            ..|               ||....::|:|..|:: ::.....|.:||||:|||.:.:||...|||
  Fly   126 AHP---------------GLTYLTMQDLFDKIQAQSDVRKFDVGVSYLEVYNEHVMNLLTKSGPL 175

  Fly   201 ELREDHRGQRITVAGLSEITTSSRKEVVSLLLKGNKARTMEPTAANQTSSRSHALLSIMVQ-ART 264
            :||||:.|  :.|:||......|.:|::.:|:.||..||..||.||..||||||:..:.:: ...
  Fly   176 KLREDNNG--VVVSGLCLTPIYSAEELLRMLMLGNSHRTQHPTDANAESSRSHAIFQVHIRITER 238

  Fly   265 PLGTKQG-RLFLTDLAGSERAKKTKNRGKRLQEGAHINRSLLALGNVINGLSGGARYVNYRDSKL 328
            ...||:. :|.:.||||||||..||..|.|.:|||.||:|||||||.||.|:.|.:::.||||.|
  Fly   239 KTDTKRTVKLSMIDLAGSERAASTKGIGVRFKEGASINKSLLALGNCINKLADGLKHIPYRDSNL 303

  Fly   329 TRLLKEALSGRCKTVMIAHVAPESKHRDETKNTLVYADRANSITTKLQNSVYIDEFKDFPTKHYQ 393
            ||:||::|.|.|:|:|:|:|:..|...::|.|||.||.||..|.|.|:.:|...:   .||:.|.
  Fly   304 TRILKDSLGGNCRTLMVANVSMSSLTYEDTYNTLKYASRAKKIRTTLKQNVLKSK---MPTEFYV 365

  Fly   394 SLVSELRDEVSRL--RTKML----TERPRSGAAA--------------AAAAAAASGSAGTAGSG 438
            ..:.|:..|..||  |.|.|    |:..|:|.:.              |..|||........|..
  Fly   366 KKIDEVVAENERLKERNKALEAKATQLERAGNSGFDPLELKTWYSKIDAVYAAARQLQEHVLGMR 430

  Fly   439 A------------------------GSEAVQE--------------QDEQRKTELRYLREQIVLT 465
            :                        .....||              |.|:.|.||.....::.:.
  Fly   431 SKIKNINYRQTLKKELEEFRKLMCVDQRVCQEDFRRFANYMSTLTSQMEKYKEELPSWLSKMEIA 495

  Fly   466 FKQQMKLRRKLLEAESHLL--------GLELDAERQHMIISHWQGRIGKLYDAMGDDDIESEGSV 522
            ::....|:|::.:::::.:        .|||...:|::..:|        .:|:..:.:|:
  Fly   496 YQDLESLKREVNKSKAYQILIVYVKYKDLELQLTKQNIFNNH--------VNAINQELVEN---- 548

  Fly   523 ALKNAWGELAAIEKETRRYKEIRERTEHELEQCRQKGVKLEDELP---ERI-----SSDEEREL- 578
                    |..:.|..|...|:..:|...||.    |.||..|:.   ||:     .:|.|...
  Fly   549 --------LDLMRKSFRTACEVLNQTYDRLED----GQKLTPEIEAVFERLLRKMRFADSEANTK 601

  Fly   579 ----------LALLCRVHELEADKVSLQAERLARQAELRRRDLQLLRAERQRRLCEDIISSQRRL 633
                      :||.....|.|....||.|....||.:..:.|..|       .|..:...||
  Fly   602 MAEMNPLAVPVALRSSAQEEEEPTCSLTASAKKRQRQAAQSDDDL-------HLSMEDFDSQ--- 656

  Fly   634 IEEGNVDLPDELRELYGLYQQEIHAGVVTPSTSNYERKLPPIYTAGSDSPGSSSSS 689
                  |...:..||:..:::        |...|..:.|.|..::.|.|..||||:
  Fly   657 ------DTESDSEELHRTFKR--------PRNLNETQVLGPCSSSSSSSTSSSSSA 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kif19A	NP_996208.1	Motor_domain	35..371	CDD:277568	146/363 (40%)
Kif19A	NP_996208.1	Kinesin	41..371	CDD:278646	143/357 (40%)
Klp67A	NP_001286999.1	KISc	8..353	CDD:214526	149/370 (40%)
Klp67A	NP_001286999.1	KISc_KIP3_like	8..346	CDD:276821	146/363 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437999
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0242
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000448
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100835
Panther	1	1.100	-	-	P	PTHR24115
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R640
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.770