DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kif19A and Klp64D

DIOPT Version :9

Sequence 1:	NP_996208.1	Gene:	Kif19A / 41717	FlyBaseID:	FBgn0038205	Length:	750	Species:	Drosophila melanogaster
Sequence 2:	NP_523934.1	Gene:	Klp64D / 38611	FlyBaseID:	FBgn0004380	Length:	677	Species:	Drosophila melanogaster

Alignment Length:	726	Identity:	207/726 - (28%)
Similarity:	319/726 - (43%)	Gaps:	173/726 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 TAQPAQE-ERLVVAVRVRP--------------SMEATERCIEVISGGSLLYDDGGKSRPRQYSY 76
            |||...| |.:.|.||.||              |::...|.|.|:...:.     ....|:.|.:
  Fly    11 TAQLDDEIENVRVVVRTRPMDKNELSAGALSAISVDKINRAITVMKPNAT-----ANEPPKTYYF 70

  Fly    77 DHVFRENDSQEQVYKTTTAPLVRDVLNGLNAAVFAYGATGSGKTHTMLG-PVPRKKPQTSDRAPP 140
            |:||....:|..:|..|..|:|..||.|.|..:.|||.||:|||:||.| |   ..|||.
  Fly    71 DNVFDGGSNQMDLYVDTARPIVDKVLEGYNGTILAYGQTGTGKTYTMSGNP---DSPQTK----- 127

  Fly   141 TASCDSTDVSSQDIGLMVRAIEDIFSHIESA-EAYSCRVSISYLEIYNELIRDLL--NPGGPLEL 202
                          |::..|...||.||..| |.....|.:||:|||||.:||||  :.|..||:
  Fly   128 --------------GIIPNAFAHIFGHIAKAKENQKFLVRVSYMEIYNEEVRDLLGKDVGKSLEV 178

  Fly   203 REDHRGQRITVAGLSEITTSSRKEVVSLLLKGNKARTMEPTAANQTSSRSHALLSIMVQARTPLG 267
            :| .....:.|..||.....:..::.:::..|||.|.:..|..||.||||||:.||.|: |:.||
  Fly   179 KE-RPDIGVFVKDLSGYVVHNADDLENIMRLGNKNRAVGATKMNQESSRSHAIFSITVE-RSELG 241

  Fly   268 ------TKQGRLFLTDLAGSERAKKTKNRGKRLQEGAHINRSLLALGNVINGL-SGGARYVNYRD 325
                  .:.|:|.|.|||||||..||:..|:||:|...||.||..|||||:.| .|.:.::.||:
  Fly   242 EGDVQHVRMGKLQLVDLAGSERQSKTQASGQRLKEATKINLSLSVLGNVISALVDGKSTHIPYRN 306

  Fly   326 SKLTRLLKEALSGRCKTVMIAHVAPESKHRDETKNTLVYADRANSITTKLQNSVYI-DEFKDFPT 389
            |||||||:::|.|..||||.|.::|...:..||.:||.||.||.:|    ||.::| :|.||...
  Fly   307 SKLTRLLQDSLGGNSKTVMCATISPADSNYMETISTLRYASRAKNI----QNRMHINEEPKDALL 367

  Fly   390 KHYQSLVSELRDEVSRLRTKM-----LTERPRSG-------------------AAAAAAAAAASG 430
            :|:|       :|::|||.::     |.|.|.|.                   .::...|.....
  Fly   368 RHFQ-------EEIARLRKQLEEGDSLEEEPPSSEEEEDTADDELEAPLEIELESSTIQAVEKKP 425

  Fly   431 SAGTAGSGAGSEAVQEQDEQRKTELRYLREQIVLTFKQQMKLRRKLLEAESHLL----GLELDAE 491
            ......:.|..|.:.::..:.:.|:.:.:       .:|..||.||:..|..:|    .|...|:
  Fly   426 KKKREKTDAEKEELAKRKNEHQKEIEHAK-------TEQETLRNKLVSLEGKILVGGENLLEKAQ 483

  Fly   492 RQHMIISHWQGRIGKLYDAMGDDDIESEGSVALKNAWGELAAIEKETRRYKEIRERTEHELEQCR 556
            .|.:::                     |.|:|      ||           |..|::|..|:|
  Fly   484 TQELLL---------------------EQSIA------EL-----------EQHEKSEEALKQ-- 508

  Fly   557 QKGVKLEDELPERISSDEERELL-----ALLCRVHELEADKVSLQAERLARQAELRRRDLQ---- 612
                .|:.:..|||..:|....|     .:..::|.:....:.:::| ||.|.:..:|:.:
  Fly   509 ----TLQQKATERIDIEERYSTLQDASTGITKKIHRVMQMLMGVKSE-LADQQQEHQREKEGIYE 568

  Fly   613 -LLRAERQRRLCEDIISSQRRLIEEGNVDLPDELRELYGLYQQ------EIHAGVVTPSTSNYER 670
             :....|:..|||.:::|.          :|.|.:.:...|..      |.....|..:.:|..:
  Fly   569 NIRSLSRELALCELVLNSY----------VPKEYQSMINQYTHWNEDIGEWQLKCVAYTGNNMRK 623

  Fly   671 KLPPIYTAGSD 681
            .:....|:|.:
  Fly   624 HISAHKTSGKE 634

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kif19A	NP_996208.1	Motor_domain	35..371	CDD:277568	136/360 (38%)
Kif19A	NP_996208.1	Kinesin	41..371	CDD:278646	134/354 (38%)
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	137/361 (38%)
		Kinesin	26..352	CDD:278646	134/354 (38%)
		RILP-like	<437..556	CDD:304877	32/170 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437781
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940