DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kif19A and KIF22

DIOPT Version :9

Sequence 1:	NP_996208.1	Gene:	Kif19A / 41717	FlyBaseID:	FBgn0038205	Length:	750	Species:	Drosophila melanogaster
Sequence 2:	XP_024306038.1	Gene:	KIF22 / 3835	HGNCID:	6391	Length:	723	Species:	Homo sapiens

Alignment Length:	799	Identity:	216/799 - (27%)
Similarity:	336/799 - (42%)	Gaps:	180/799 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 SSGGSNSSQGRSIATAQPA-------------------QEERLVVAVRVRPSMEAT-----ERCI 53
            ::|||...:.|.:|.|..|                   ...|:.||||:||.::.|     ..|:
Human     2 AAGGSTQQRRREMAAASAAAISGAGRCRLSKIGATRRPPPARVRVAVRLRPFVDGTAGASDPPCV 66

  Fly    54 EVISGGSL-LYDDGGKSRPRQYSYDHVFRENDSQEQVYKTTTAPLVRDVLNGLNAAVFAYGATGS 117
            ..:...|| :.:........:|.:|..:.|..:|:.:|..:..|::|.:|.|.||:|.|||.||:
Human    67 RGMDSCSLEIANWRNHQETLKYQFDAFYGERSTQQDIYAGSVQPILRHLLEGQNASVLAYGPTGA 131

  Fly   118 GKTHTMLGPVPRKKPQTSDRAPPTASCDSTDVSSQDIGLMVRAIEDI--FSHIESAEA--YSCRV 178
            ||||||||                        |.:..|::.||:.|:  .:..|.||.  ::..|
Human   132 GKTHTMLG------------------------SPEQPGVIPRALMDLLQLTREEGAEGRPWALSV 172

  Fly   179 SISYLEIYNELIRDLLNP-GGPLELREDHRGQRITVAGLSEITTSSRKEVVSLLLKGNKARTMEP 242
            ::||||||.|.:.|||:| .|.|.:|||.|| .|.:.|||:...||..:.....|..::.||:..
Human   173 TMSYLEIYQEKVLDLLDPASGDLVIREDCRG-NILIPGLSQKPISSFADFERHFLPASRNRTVGA 236

  Fly   243 TAANQTSSRSHALLSIMVQAR---TPLGTKQGRLFLTDLAGSERAKKTKNRGKRLQEGAHINRSL 304
            |..||.||||||:|.:.|..|   .|...::|:|:|.||||||..::|.|:|.||:|...||.||
Human   237 TRLNQRSSRSHAVLLVKVDQRERLAPFRQREGKLYLIDLAGSEDNRRTGNKGLRLKESGAINTSL 301

  Fly   305 LALGNVINGLSGGARYVNYRDSKLTRLLKEALSGRCKTVMIAHVAPESKHRDETKNTLVYADRAN 369
            ..||.|::.|:.|...|.||||||||||:::|.|...:::||::|||.:...:|.:.|.:|.|:.
Human   302 FVLGKVVDALNQGLPRVPYRDSKLTRLLQDSLGGSAHSILIANIAPERRFYLDTVSALNFAARSK 366

  Fly   370 SITTKLQNSVYIDEFKDFPTKHYQSLVSELRDEVSRLRTKMLTERPRSGAAAAAAAAAASGSAGT 434
            .:..:...:..:......|.|..|   .||.......|.:...|.........||.|:||
Human   367 EVINRPFTNESLQPHALGPVKLSQ---KELLGPPEAKRARGPEEEEIGSPEPMAAPASAS----- 423

  Fly   435 AGSGAGSEAVQEQDEQRKTELRYLREQIVLTFKQQMKLRRKLLEAESHLLGLELDAERQHMIISH 499
                           |:.:.|:.|........::.:.|.|.|....|....|....:|:.|:
Human   424 ---------------QKLSPLQKLSSMDPAMLERLLSLDRLLASQGSQGAPLLSTPKRERMV--- 470

  Fly   500 WQGRIGKLYDAMGDDDIESEGSVALKNAWGELAAIEKETRRYKEIRERTEHELEQCRQKGVKLED 564
                   |...:.:.|:|                ||:...:.||:      |.:...||..:.|:
Human   471 -------LMKTVEEKDLE----------------IERLKTKQKEL------EAKMLAQKAEEKEN 506

  Fly   565 ELPERISSDEERELL-------ALLCRVHELEADKVSLQAERLARQAELRRRDLQLLRAERQRRL 622
            ..|..:.....|.:.       |::..:..::....|..||....:.:.|:|.|:.|.|......
Human   507 HCPTMLRPLSHRTVTGAKPLKKAVVMPLQLIQEQAASPNAEIHILKNKGRKRKLESLDALEPEEK 571

  Fly   623 CED---------IISSQRR----LIEEGNV-DL-------PDEL------RELYGLYQQEIHAGV 660
            .||         :::..|:    |:.||:. ||       |.:.      |||:|.:.|
Human   572 AEDCWELQISPELLAHGRQKILDLLNEGSARDLRSLQRIGPKKAQLIVGWRELHGPFSQ------ 630

  Fly   661 VTPSTSNYERKLPPIYTAGSDSPGSSSSSEWSPASPLPQIDNQMDPVDRVMGPPVNPRLPRLSAA 725
                       :...:|.|....|...:.|  ..||:       |||....||...   ...:..
Human   631 -----------VAAHWTGGGRGRGRPGTPE--TLSPI-------DPVPPGGGPGTR---GGHNGE 672

  Fly   726 TSANVPAG---GS-RRPSL 740
            |...:|.|   || |||:|
Human   673 TDGVLPEGKHPGSRRRPAL 691

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kif19A	NP_996208.1	Motor_domain	35..371	CDD:277568	131/349 (38%)
Kif19A	NP_996208.1	Kinesin	41..371	CDD:278646	127/343 (37%)
KIF22	XP_024306038.1	KISc_KID_like	43..366	CDD:276827	131/347 (38%)
KIF22	XP_024306038.1	ComEA	<596..632	CDD:333350	10/52 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0242
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000448
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810