Protein Alignment Kif19A and kif1b

DIOPT Version :10

• Sequence 1: NP_996208.1
• Gene: Kif19A / 41717
• FlyBaseID: FBgn0038205
• Length: 750
• Species: Drosophila melanogaster
• Sequence 2: XP_068072796.1
• Gene: kif1b / 369190
• ZFINID: ZDB-GENE-030820-1
• Length: 1927
• Species: Danio rerio
• Alignment Length: 836
• Identity: 218/836 - (26%)
• Similarity: 343/836 - (41%)
• Gaps: 232/836 - (27%)

  Fly    38 VAVRVRP--SMEA--TERCIEVISGGS-LLYDDGGKSRPRQYSYDHVFREND--------SQEQV 89
            |||||||  |.|.  ..:||..:.|.| .:.:......|:.:|:|:.:..:.        ||.||
Zfish     8 VAVRVRPFNSRETGKESKCIIQMQGNSTTILNPKNPKEPKTFSFDYSYWSHTSPDDPSFASQNQV 72

  Fly    90 YKTTTAPLVRDVLNGLNAAVFAYGATGSGKTHTMLGPVPRKKPQTSDRAPPTASCDSTDVSSQDI 154
            |......:::....|.|..:||||.||:||::||:|    |:.:..:
Zfish    73 YNDIGKEMLQHAFEGYNVCIFAYGQTGAGKSYTMMG----KQEEGQE------------------ 115

  Fly   155 GLMVRAIEDIFSHI--ESAEAYSCRVSISYLEIYNELIRDLLNP--GGPLELREDHRGQRITVAG 215
            |::.:..|::|..|  .:.|..|..|.::|:|||.|.:||||||  .|.|.:|| |......|..
Zfish   116 GIIPQLCEELFEKINDNNNEEISYSVEVAYMEIYCERVRDLLNPKNKGNLRVRE-HPLLGPYVED 179

  Fly   216 LSEITTSSRKEVVSLLLKGNKARTMEPTAANQTSSRSHALLSIMVQAR-----TPLGT-KQGRLF 274
            ||::..:|..::..|:..||||||:..|..|:|||||||:.:|:...|     |.|.| |..::.
Zfish   180 LSKLAVTSYTDIADLMDAGNKARTVAATNMNETSSRSHAVFTIVFTQRKYDSETDLSTEKVSKIS 244

  Fly   275 LTDLAGSERAKKTKNRGKRLQEGAHINRSLLALGNVINGLS------------GGARYVNYRDSK 327
            |.||||||||..|..:|.||:|||:||:||..||.||:.|:            ....::.||||.
Zfish   245 LVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEVDNCTSKSKKKKKTDFIPYRDSV 309

  Fly   328 LTRLLKEALSGRCKTVMIAHVAPESKHRDETKNTLVYADRANSITTKLQNSVYIDEFKDFPTKHY 392
            ||.||:|.|.|..:|.|:|.::|...:.|||.:||.|||||..|..   |:|..::    |.
Zfish   310 LTWLLRENLGGNSRTAMVAALSPADINFDETLSTLRYADRAKQIKC---NAVINED----PN--- 364

  Fly   393 QSLVSELRDEVSRLR-------------------------TKML---------------TERPRS 417
            ..||.||:||||||:                         :|.|               .:||..
Zfish   365 AKLVRELKDEVSRLKELLRAQGLGDILDIEPMGDDCLGSGSKYLKDIHNNKHRYLLASENQRPGH 429

  Fly   418 GAAAAAAAAAASGSAGTAGSGAGSEAVQEQDEQRKTELRYLREQIVLTFKQQMKLRRKLLEAESH 482
            .:.|......||.|:|:..|.||.::|..           ::|:|:.|...:..:.| |.|:|..
Zfish   430 FSTAPMGCLTASPSSGSLCSQAGLQSVSS-----------IQERIMSTPGGEEAIER-LKESEKI 482

  Fly   483 LLGLELDAERQHMIISHWQGRIGKLYDA--MGDDDIESEGSVALKNAWGELAA------------ 533
            :..|.          ..|:.::.|. :|  |..:.:.:|..||::...|.|..
Zfish   483 IAELN----------ETWEEKLRKT-EAIRMEREALLAEMGVAIREDGGTLGVFSPKKFGPDRPT 536

  Fly   534 ----------------IEKETRRYKEIR-----ERTEH--------ELEQCRQKGVKLEDELPER 569
                            :|:....|.:..     ::|.|        .:.:|....:|  |.:...
Zfish   537 SLSIEDFSVYSSNQLFVERPCEVYTDFNGVFSPKKTPHLVNLNEDPLMSECLLYYIK--DGITRV 599

  Fly   570 ISSDEERELLALLCRVH-----------------------ELEADKVSLQAERLARQAELRRRDL 611
            ..:|.||....:|...|                       ..|..:..:..:|:....:||..:.
Zfish   600 GQADAERRQDIVLSGAHIKEEHCIFRSERNANGHVIVTLEPCEGSETYVNGKRVNSAVQLRSGNR 664

  Fly   612 QLL--------------RAERQRRLCE-------DIISSQRRLIEEGNVDLPDE----LRELYGL 651
            .::              ||||::....       |...:||.|:|:..:|:..|    |.|:..|
Zfish   665 IIMGKNHVFRFNHPEQARAEREKTPSAETPVEPVDWTFAQRELLEKQGIDMKQEMEKRLTEMEIL 729

  Fly   652 YQQEIHAG--VVTPSTSNYERKLPPIY------TAGSDSPGSSSSSEWSPASPLPQ 699
            |::|....  ::......||.||..:.      :..:::|......|.....|..|
Zfish   730 YKKEKEEADQLLEQQRLVYESKLQELQKQVETRSLAAETPDEEEEEEEEDEVPWTQ 785

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kif19A	NP_996208.1	Motor_domain	35..371	CDD:473979	134/367 (37%)
		SMC_prok_B	<393..672	CDD:274008	74/411 (18%)
kif1b	XP_068072796.1	KISc_KIF1A_KIF1B	4..360	CDD:276816	137/377 (36%)
		Kinesin_assoc	357..596	CDD:465047	49/270 (18%)
		FHA_KIF1B	571..680	CDD:438779	14/110 (13%)
		GBP_C	<680..754	CDD:293879	20/73 (27%)
		KIF1B	889..937	CDD:463574
		KIF1B	<999..1021	CDD:463574
		DUF3694	1373..1529	CDD:463599
		PH_KIFIA_KIFIB	1808..1910	CDD:269939