DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kif19A and Khc-73

DIOPT Version :9

Sequence 1:	NP_996208.1	Gene:	Kif19A / 41717	FlyBaseID:	FBgn0038205	Length:	750	Species:	Drosophila melanogaster
Sequence 2:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster

Alignment Length:	736	Identity:	202/736 - (27%)
Similarity:	323/736 - (43%)	Gaps:	183/736 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 ERLVVAVRVRP----SMEATERCI-EVISGGSLLYDDG-----GKSRPRQYSYDHVF------RE 82
            :::.|||||||    .:|...:|| |:....::|.:..     .:.:|:.:::||.|      .|
  Fly     4 DKIKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLEKIERKQPKTFAFDHCFYSLNPEDE 68

  Fly    83 N-DSQEQVYKTTTAPLVRDVLNGLNAAVFAYGATGSGKTHTMLGPVPRKKPQTSDRAPPTASCDS 146
            | .|||.|:......::.:...|.||.:||||.|||||::||:|
  Fly    69 NFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMG--------------------- 112

  Fly   147 TDVSSQDIGLMVRAIEDIFSHI--ESAEAYSCRVSISYLEIYNELIRDLLNP---GGPLELREDH 206
               :.:..|::.|..:.:||.|  :|......:|.:||:|||||.:.|||:|   ...|::|| |
  Fly   113 ---TQESKGIIPRLCDQLFSAIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVRE-H 173

  Fly   207 RGQRITVAGLSEITTSSRKEVVSLLLKGNKARTMEPTAANQTSSRSHALLSIMV------QARTP 265
            ......|.|||::..:|.:::.:|:.:|||:||:..|..|..||||||:.|:::      ||...
  Fly   174 NVMGPYVDGLSQLAVTSYQDIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGV 238

  Fly   266 LGTKQGRLFLTDLAGSERAKKTKNRGKRLQEGAHINRSLLALGNVINGL--------SGGARYVN 322
            .|.|..|:.|.||||||||.||...|.||:||::||:||..||.||:.|        ||..::|.
  Fly   239 SGEKVSRMSLVDLAGSERAVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVP 303

  Fly   323 YRDSKLTRLLKEALSGRCKTVMIAHVAPESKHRDETKNTLVYADRANSITTKLQNSVYIDEFKDF 387
            ||||.||.|||:.|.|..:|||:|.::|.:.:.:||.:||.|||||..|.    |...::|..:
  Fly   304 YRDSVLTWLLKDNLGGNSRTVMVATISPSADNYEETLSTLRYADRAKRIV----NHAVVNEDPN- 363

  Fly   388 PTKHYQSLVSELRDEVSRLRTKMLTERPRSGAAAAAAAAAASGSAGTAGSGAGSEAVQEQDEQRK 452
                 ..::.|||.||..||: ||..                        ..||.....||:..:
  Fly   364 -----ARIIRELRHEVETLRS-MLKH------------------------ATGSPVGDVQDKLAE 398

  Fly   453 TELRYLREQIVLTFKQQM-KLRR---------------------KLLEAESHLLGLELDAERQHM 495
            :|  .|.:||..|::::: |..|                     |:.:.:.:|:.|..|.....:
  Fly   399 SE--NLMKQISQTWEEKLVKTERIQNERQQALEKMGISVQASGIKVEKNKYYLVNLNADPSLNEL 461

  Fly   496 IISHWQGR--IGKLYDAMGDDDIESEG---------------SVALKNAWGE------LAAIEKE 537
            ::.:.:.|  ||....:....||:..|               .:.::...|.      .||:||.
  Fly   462 LVYYLKDRTLIGGRTISGQQPDIQLSGLGIQPEHCVITIEDSGLYMEPVQGARCFVNGSAAVEKT 526

  Fly   538 -----------TRRYKEIRERTEHELEQCRQKGVKLEDELPERI-----SSDEERELLALLCRVH 586
                       ...:..:.....:....|..     |.:.|.::     :.||..:        :
  Fly   527 PLQNGDRILWGNHHFFRVNSPKSNNTSMCAS-----EPQTPAQLIDYNFARDEIMQ--------N 578

  Fly   587 ELEADKVSLQAERLARQAELRRRDLQLLRAERQRRLCEDIISSQRRLIEEGNVDLPDELRELYGL 651
            ||..|.:.....||.||.|   .|.| :..|:||:..|......|.::.......|      |..
  Fly   579 ELSNDPIQTAIARLERQHE---EDKQ-VALEKQRQEYERQFQQLRNILSPSTPYAP------YAP 633

  Fly   652 YQQEIHAGVVTPSTSNYERKL 672
            | ..:..|.:||:|...:.::
  Fly   634 Y-DPLRMGKITPNTPTSQMRV 653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kif19A	NP_996208.1	Motor_domain	35..371	CDD:277568	137/371 (37%)
Kif19A	NP_996208.1	Kinesin	41..371	CDD:278646	134/365 (37%)
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	139/383 (36%)
		KISc	6..359	CDD:214526	139/381 (36%)
		Kinesin_assoc	356..468	CDD:292801	25/144 (17%)
		FHA	446..546	CDD:238017	14/99 (14%)
		KIF1B	741..786	CDD:289208
		DUF3694	<1196..1252	CDD:289256
		CAP_GLY	1786..1850	CDD:279625
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437759
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940