DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kif19A and CG5004

DIOPT Version :9

Sequence 1:	NP_996208.1	Gene:	Kif19A / 41717	FlyBaseID:	FBgn0038205	Length:	750	Species:	Drosophila melanogaster
Sequence 2:	NP_573195.1	Gene:	CG5004 / 32698	FlyBaseID:	FBgn0260748	Length:	1247	Species:	Drosophila melanogaster

Alignment Length:	844	Identity:	155/844 - (18%)
Similarity:	266/844 - (31%)	Gaps:	316/844 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 GLMVRAIEDIFSHIES---AEAYSCRVSIS-------YLEIY----NELI----RD--LLNPGGP 199
            |.:..|:...:.||..   ..|.||.:|::       :..||    ||:.    :|  ||..|.|
  Fly    25 GRLSTAVTIHYIHIGDTTIGSAASCSISLNGSGVRPLHCTIYRSDANEVTLVPEKDSRLLIDGAP 89

  Fly   200 -LELREDHRGQRITVAGLSEITTSSRKE--VVSLLLKGNKARTMEPTAANQTSSRSHA------- 254
             ||..:..:|..||:...:.:..::..|  ::...:..|:..:|......|::.::|.
  Fly    90 ILEETKLSQGAMITIGNSNYLRFNNPDEAQMMRSAMGSNERISMPQIDFTQSARQAHELSQSLEL 154

  Fly   255 ----------------------------LLSIMVQARTPLGTKQGRLFLTDLAGSERAKKTKNRG 291
                                        |:::.:.|:..||.|... |..:||.:.|.:|..|
  Fly   155 ESFYESIINPINNPSTYELECPKVFSSDLVTVNMPAKDVLGQKYAS-FARNLAENHRNEKQLN-- 216

  Fly   292 KRLQEGAHINRSLLALGNVINGLSGGARYVNYRDSK--------LTRLLKEAL-----SGRCKTV 343
            .:..:|...|      |...|..|..|.|......:        ||::..:..     :|..:..
  Fly   217 NQYAKGVGSN------GGYWNVPSNAAIYKEQHQQQHQQAPQDLLTKVNNDRYDRYPKAGGLQIY 275

  Fly   344 MIAHVAPESKHRDETKNT----------------LVYADRANSITTKLQNSVYIDEFKDFPTKHY 392
            .:..|..:..:...|.|.                ..||||.||:                |:.|.
  Fly   276 SMNGVNSDINNGPATGNNSGTGGGAELEDMLKICTEYADRNNSM----------------PSTHN 324

  Fly   393 QSLVSELRDE---VSRLRTKMLTERPR--------SGAAAAAAAAAASGSAG------------- 433
            .|..|.:...   .:|::|.....|.:        :|.|::|..:..|.|:|
  Fly   325 VSSTSSITSSPIVQNRIKTNGSLPRDKNKSPFPQQAGVASSANISLLSSSSGYENVRLLGPNRVE 389

  Fly   434 ---------TAGSGAGSEAVQ-----------------EQDEQRKTELRYLREQIVLTFKQQMKL 472
                     :||.|..|..|.                 .|:....|..:|:.:      ..:.|:
  Fly   390 INGQIHVPASAGDGGSSSGVSSNALAPTAAVRASHENLNQNHSATTGGKYVPQ------SPRTKI 448

  Fly   473 RRKLLE--------------------AESHLLGL-----------------------ELDAERQH 494
            |...:.                    |.|.::..                       :.|.|:..
  Fly   449 RTNCMSPKKDVSFGNAFALAISPPPLASSAVVSTSKPIPIPSMVKPPLAPKPPAPNQQRDYEQLF 513

  Fly   495 MIISHWQGRIGKLYDAMGDDDIESEGSVALKNAWGELAAIEKETRRYK------------EIRER 547
            ......|.::.::..|       ...:..:.|....|.::|.:|:..|            .:.:|
  Fly   514 KSFERKQQQLDRMVPA-------KRSNKNINNLTLNLQSVESQTQSPKPSRKPAPAPRSIHLEQR 571

  Fly   548 TEHELEQCRQ---------------KGVKLE-DELPERISSDEERELLALLCRVHELEADKVSL- 595
            ...||.|.|:               :|::|: .|.|...|:....:|.||..||..|||.:.:.
  Fly   572 QRRELIQRRKQLKRELAELPPSAGIEGLELKLGEQPLAPSASPRLQLQALQNRVCRLEAQRNATR 636

  Fly   596 -----QAERLARQAELRRRDLQLLRA------------ERQRRLCEDIISSQRRLIEEGNVDLPD 643
                 |..:|.:..|:::..|:.|||            |..:.:||. :.|.|:..|
  Fly   637 VMEENQQAKLKQSIEIKQDQLKKLRAMLKQKPNNACLKEELQLVCES-LESDRKTFE-------- 692

  Fly   644 ELRELYGLYQQEIHAGVVTPSTSNYERKL--------------PPIYTAGS-DSPGSS------- 686
            :|...|...:.|.||.  .......|::|              |.....|| .||||:
  Fly   693 DLEFQYFEEESEHHAS--HEEFKRQEQRLMLEAELAALRIQIGPDEEEPGSPTSPGSTGSNLVNG 755

  Fly   687 --SSSEWSPASPL-PQIDNQMDPVDRVMGPPVNPRL---PRLSAATSA--NVP-------AGGS 735
              |.|.:..|..| |:..||.|    :|...||..:   .::.|.||.  .:|       ||||
  Fly   756 VMSQSLFGSAELLCPKRRNQED----LMSKSVNENMFYNHKIEANTSTPKRLPLQLFEDLAGGS 815

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kif19A	NP_996208.1	Motor_domain	35..371	CDD:277568	56/302 (19%)
Kif19A	NP_996208.1	Kinesin	41..371	CDD:278646	56/302 (19%)
CG5004	NP_573195.1	FHA	41..104	CDD:278899	17/62 (27%)
		PH-like	1142..1242	CDD:302622
		PH	1143..1237	CDD:278594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437957
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930