DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kif19A and Kif6

DIOPT Version :9

Sequence 1:	NP_996208.1	Gene:	Kif19A / 41717	FlyBaseID:	FBgn0038205	Length:	750	Species:	Drosophila melanogaster
Sequence 2:	NP_796026.2	Gene:	Kif6 / 319991	MGIID:	1098238	Length:	802	Species:	Mus musculus

Alignment Length:	697	Identity:	174/697 - (24%)
Similarity:	286/697 - (41%)	Gaps:	126/697 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 EERLVVAVRVRPSM-------------EATERCIEVISGGSLLYDDG---GKSRPRQYSYDHVFR 81
            ::.:.:..||:|::             |.....:|::....|.  ||   .|....::.:..:|.
Mouse     3 KQTIQIFARVKPTVRKQQQGIYSIDEDEKLTHSLEIVLPRDLA--DGFVNNKRESYKFKFQRIFD 65

  Fly    82 ENDSQEQVYKTTTAPLVRDVLNGLNAAVFAYGATGSGKTHTMLGPVPRKKPQTSDRAPPTASCDS 146
            :...||.:::....|:....|.|.|..:||||.||||||.|:.|...|    .|||
Mouse    66 QEAKQEIIFEIIAKPVAESTLAGYNGTIFAYGQTGSGKTFTITGGAER----YSDR--------- 117

  Fly   147 TDVSSQDIGLMVRAIEDIFSHIESAEAYSCRVSISYLEIYNELIRDLLNPGGPLELRED------ 205
                    |::.|.:..||..::...:......|||||||||...|||:|.......||
Mouse   118 --------GIIPRTLSYIFEQLQKDSSKIYTTHISYLEIYNECGYDLLDPRHEASKLEDLPKVTI 174

  Fly   206 --HRGQRITVAGLSEITTSSRKEVVSLLLKGNKARTMEPTAANQTSSRSHALLSIMVQARTP--L 266
              ...|.|.:..||....::.:|.::||..|:..|.:..|..||.|:|||.:.::.:.::.|  .
Mouse   175 LEDPDQNIHLKNLSLHQATTEEEALNLLFLGDTNRMIAETPMNQASTRSHCIFTVHLSSKEPGSA 239

  Fly   267 GTKQGRLFLTDLAGSERAKKTKNRGKRLQEGAHINRSLLALGNVINGLSGGAR-YVNYRDSKLTR 330
            ..:..:|.|.|||||||..||...|..|.|..:||.||..|..||..||...| ::.||:|.:|.
Mouse   240 TVRHAKLHLVDLAGSERVSKTGVGGLLLTEAKYINLSLHYLEQVIIALSEKHRTHIPYRNSMMTS 304

  Fly   331 LLKEALSGRCKTVMIAHVAPESKHRDETKNTLVYADRANSITTKLQNSVYIDEFKDFP------- 388
            :|:::|.|.|.|.|||.::.|.::.||:.:|..:|.|    ...::|...::|..| |
Mouse   305 VLRDSLGGNCMTTMIATLSLEKRNIDESISTCRFAQR----VALIKNEAILNEEID-PRLMIVRL 364

  Fly   389 TKHYQSLVSELRDEVSRLRTKMLTERPRSGAAAAAAAAAASGSAGTAGSGAGSEAVQEQDEQRKT 453
            .|..:.|.:||.......||:.|||..........|:                 .:::||.:.:.
Mouse   365 QKEIEDLKAELAMATGEQRTEALTEAELLQLEKLIAS-----------------YLEDQDPESRL 412

  Fly   454 ELRYLREQIVLTFKQQMKL--RRKLLE----AES---------------HLLGLELDAERQ-HMI 496
            |:.....:|...|....||  .:|.||    :||               .||||....:.: :::
Mouse   413 EVGADMRKIHHCFHHFKKLLNDKKTLENTVSSESTRQACQEPLRDEEYTKLLGLLKQRDNEINIL 477

  Fly   497 ISHWQGRIGKLYDAMGDDDIESEGSVALKNAWGELAAIEKETRRYKEIRERTEHELEQCRQKGVK 561
            ::..:....|..||:.:..:|...:...:|:.....:.......:......|: :|..||.:...
Mouse   478 VNMLKKEKKKTQDALQNSSLEKSDTRPPQNSPFIAGSPAVPRTPFSSAPSHTQ-DLSICRHRSSL 541

  Fly   562 LEDE--LPERISSDEERELLALLCRVHELEADKVSL------------QAERLARQA-ELRRRDL 611
            |..:  :.|.:|...: |...:..|.|   ||.|::            :|:.|.... |.|.:..
Mouse   542 LHKKTGMREEMSLGRQ-EAFEIFKRDH---ADSVTIEDNKQVLKQRFSEAKALGESINEARSKIG 602

  Fly   612 QLLRAERQRRLCEDIISSQRRLIEEGNVDLPDE-----LRELYGLYQ 653
            ||..|..||.|.:..:......:.....|..:|     |.|..|.|:
Mouse   603 QLKDAINQRHLQQVALGISENTVPASTPDPQEEKLRAQLEEEKGRYK 649

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kif19A	NP_996208.1	Motor_domain	35..371	CDD:277568	110/362 (30%)
Kif19A	NP_996208.1	Kinesin	41..371	CDD:278646	110/356 (31%)
Kif6	NP_796026.2	KISc_KIF9_like	5..343	CDD:276826	110/364 (30%)
		Kinesin	11..345	CDD:278646	110/360 (31%)
		Cob_adeno_trans	<350..>408	CDD:294596	14/75 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0242
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810