DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kif19A and Kif18b

DIOPT Version :9

Sequence 1:	NP_996208.1	Gene:	Kif19A / 41717	FlyBaseID:	FBgn0038205	Length:	750	Species:	Drosophila melanogaster
Sequence 2:	XP_008766505.1	Gene:	Kif18b / 303575	RGDID:	1310360	Length:	841	Species:	Rattus norvegicus

Alignment Length:	781	Identity:	234/781 - (29%)
Similarity:	344/781 - (44%)	Gaps:	193/781 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 AQEERLV-VAVRVRP----SMEATER-CIEVISGGSLLYD----DGG---------------KSR 70
            |.|:.:| |.|||||    .:|:..| .|:|:....|::|    |||               |.:
  Rat     4 AVEDSVVRVVVRVRPPTPKELESQRRPVIQVVDERMLVFDPEECDGGFPGLKWSGSLSGPKKKGK 68

  Fly    71 PRQYSYDHVFRENDSQEQVYKTTTAPLVRDVLNGLNAAVFAYGATGSGKTHTMLGPVPRKKPQTS 135
            ...:.:|.||.|..:|:.|::.||..::...|.|.|.:||||||||:||||||||
  Rat    69 DLTFVFDRVFSEVATQQDVFQHTTHNILDSFLQGYNCSVFAYGATGAGKTHTMLG---------- 123

  Fly   136 DRAPPTASCDSTDVSSQDIGLMVRAIEDIFSHIESA-EAYSCRVSISYLEIYNELIRDLLNPGGP 199
                          ...|.|:|.....:::..:|:. |.....|.|||||:|||.|.|||.|.||
  Rat   124 --------------REGDPGIMYLTTMELYRRLEACQEEKQFEVLISYLEVYNEQIYDLLEPKGP 174

  Fly   200 LELRED-HRGQRITVAGLSEITTSSRKEVVSLLLKGNKARTMEPTAANQTSSRSHALLSIMV--Q 261
            |.:||| .:|  :.|.|||....:|.::::.:|.:||.:||..||.||.|||||||:..|.|  |
  Rat   175 LTIREDPDKG--VVVPGLSFHQPASAQQLLEMLTRGNCSRTQHPTDANATSSRSHAIFQIFVKQQ 237

  Fly   262 ARTPLGTKQ----GRLFLTDLAGSERAKKTKNRGKRLQEGAHINRSLLALGNVINGLS---GGAR 319
            .|.| |..|    .::.|.||||||||..|..:|:||:|||:||||||||.||:|.|:   |...
  Rat   238 DRVP-GLTQALRVAKMSLIDLAGSERASSTHAKGERLREGANINRSLLALINVLNALADAKGRKS 301

  Fly   320 YVNYRDSKLTRLLKEALSGRCKTVMIAHVAPESKHRDETKNTLVYADRANSITTKLQNSVYIDEF 384
            :|.|||||||||||:::.|.|:|||||.|:|.|...::|.|||.|||||..|...|:::|.   .
  Rat   302 HVPYRDSKLTRLLKDSIGGNCRTVMIAAVSPSSLTYEDTYNTLKYADRAKEIRLTLKSNVI---S 363

  Fly   385 KDFPTKHYQSLVSELRDEVSRLRTKMLTERPRSGAAAAAAAAAASGSAGTAGSGAGSEAVQEQDE 449
            .|.....|.::..:|:.||:.||.|:.|..                        ||::|:|::..
  Rat   364 LDHHISQYATICQQLQAEVAALREKLQTYE------------------------AGAQALQQRSP 404

  Fly   450 QRKTELRYLREQIVLTFKQQMKLRRKLLEAESHLLGLELDAERQHMIISHWQGRIGKLYDAMGDD 514
            |...          |:..|.:..........|.....|..|:                |||..::
  Rat   405 QPPK----------LSIPQNLSSSPLQPGHSSQSCAPEFHAK----------------YDAPQEE 443

  Fly   515 ----DIESEGSVALKNAWGELAAIEKETRRYKEIRERTEHELEQCRQKGVKLEDELPERISSDEE 575
                |.:.:|:|                       |....|.||..|     :.:.|.::   .|
  Rat   444 SLGTDSQGQGTV-----------------------EENAPEQEQPPQ-----DKQFPTQM---PE 477

  Fly   576 RELLALLCRVHELEADKVSLQAERLARQAELRRRDLQLLRAERQRRLCEDIISSQRR---LIEEG 637
            ..|....|         .::||::...|..|:|.|     ||..::|...::...:|   |::..
  Rat   478 PNLPGSPC---------PTVQAKQGMNQHSLQRLD-----AEHSKQLALRVLRLAQRQYSLLQAA 528

  Fly   638 NVDLPDELRELYGLYQ----QEIHAGVVTPSTSNYERKLPPIYTAGSDSPGSSSSSEWSPASPLP 698
            |:..||.:.|...|.|    :.:..|..:|.:....|.:|......|:|.....|....||.. .
  Rat   529 NLLTPDMISEFETLQQLVLEESMEHGAESPRSPGLARGIPLAQELCSESSECPLSLSLRPACS-Q 592

  Fly   699 QIDNQMDPVDRVMGPPVN--------PRLPRLSAATSANVPAGGSRR------------PSLRVA 743
            :......||.|.|...::        |..|..::..::..|....:|            ||:.:.
  Rat   593 ESSRYCGPVTRTMAKQLSGLTHTLGIPLAPDCTSDKTSQKPTKEKKRKLNLEEPGSLPAPSVEMK 657

  Fly   744 R 744
            |
  Rat   658 R 658

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kif19A	NP_996208.1	Motor_domain	35..371	CDD:277568	158/371 (43%)
Kif19A	NP_996208.1	Kinesin	41..371	CDD:278646	155/364 (43%)
Kif18b	XP_008766505.1	KISc	18..360	CDD:214526	154/368 (42%)
Kif18b	XP_008766505.1	KISc_KIP3_like	18..353	CDD:276821	152/361 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0242
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000448
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100835
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.710