DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kif19A and Kif22

DIOPT Version :9

Sequence 1:	NP_996208.1	Gene:	Kif19A / 41717	FlyBaseID:	FBgn0038205	Length:	750	Species:	Drosophila melanogaster
Sequence 2:	NP_001009645.1	Gene:	Kif22 / 293502	RGDID:	1311886	Length:	657	Species:	Rattus norvegicus

Alignment Length:	691	Identity:	208/691 - (30%)
Similarity:	322/691 - (46%)	Gaps:	131/691 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 SGSSGGSNSSQGRSIATAQPAQEERLVVAVRVRPSMEATER--CIEVISGGSLLYDDGGK-SRPR 72
            |.|||.|.|.....::...|.  .|:.||||:||.|:..:.  |:..|...||...:..| ....
  Rat    16 SASSGPSRSLSKGGVSRRPPL--ARVRVAVRLRPFMDEAKEPPCVRGIDSCSLEVANWRKYQETL 78

  Fly    73 QYSYDHVFRENDSQEQVYKTTTAPLVRDVLNGLNAAVFAYGATGSGKTHTMLGPVPRKKPQTSDR 137
            :|.:|..:.|..:|:.||..:..|::|.:|.|.||:|.|||.||:||||||||
  Rat    79 KYQFDAFYGEKSTQQDVYVGSVQPILRHLLEGQNASVLAYGPTGAGKTHTMLG------------ 131

  Fly   138 APPTASCDSTDVSSQDIGLMVRAIEDI--FSHIESAEA--YSCRVSISYLEIYNELIRDLLNP-G 197
                        |.:..|::.||:.|:  .:..||||.  :...|::||||||.|.:.|||:| .
  Rat   132 ------------SPEQPGVIPRALMDLLQLTREESAEGRPWDISVAMSYLEIYQEKVLDLLDPAS 184

  Fly   198 GPLELREDHRGQRITVAGLSEITTSSRKEVVSLLLKGNKARTMEPTAANQTSSRSHALLSIMVQA 262
            |.|.:|||.|| .|.:.||::...:|..|.....|..::.|.:..|..||.||||||:|.:.|:.
  Rat   185 GDLVIREDCRG-NILIPGLTQKPITSFSEFEQHFLPASRNRVVGATRLNQRSSRSHAVLLVKVEQ 248

  Fly   263 R---TPLGTKQGRLFLTDLAGSERAKKTKNRGKRLQEGAHINRSLLALGNVINGLSGGARYVNYR 324
            |   ||...::|:|:|.||||||..::|.|:|.||:|...||.||..||.|::.|:.|...:.||
  Rat   249 RERLTPFRQREGKLYLIDLAGSEDNRRTGNQGIRLKESGAINTSLFVLGKVVDALNQGLPRIPYR 313

  Fly   325 DSKLTRLLKEALSGRCKTVMIAHVAPESKHRDETKNTLVYADRANSITTKLQNSVYIDEFKDFPT 389
            ||||||||:::|.|...:::||::|||.:...:|.:.|.:..|:..:..:...:..:......|.
  Rat   314 DSKLTRLLQDSLGGSAHSILIANIAPERRFYQDTISALNFTARSKEVINRPFTNESLQPHALAPV 378

  Fly   390 KHYQ-SLVSELRDEVSRLRTKMLTERPRSGAAAAAAAAAAS-----------------------G 430
            |..| .|:.....:.::...:..|..|.|.||.|:|:...|                       |
  Rat   379 KLPQKELLGPSEAKKAKGPEEESTGSPESTAAPASASQKLSLLQKLSNMDPAMLENLLSMERLLG 443

  Fly   431 SAGTAGSGAGSEAVQEQ------DEQRKTELRYLREQIVLTFKQQMKLRRKLLEAESHLLGLE-L 488
            |.|:.|....:...:|:      .|::..|:            :::|:::|.|||:  :|..| |
  Rat   444 SQGSQGIPLLNTPKRERMVLIKTVEEKNLEI------------ERLKMKQKELEAK--VLAQEAL 494

  Fly   489 DAERQHMIISHWQGRIGKLYDAMGDDDIESEGSVA--LKNA-WGELAAIEKETRRYKEIRERTEH 550
            |.:.:....:..|            ......||||  ||.| ...|..|:|::....:|     |
  Rat   495 DPKEKENTPTILQ------------PSSSCSGSVAKPLKKAVVMPLQRIQKQSESSNKI-----H 542

  Fly   551 ELEQCRQKGVKLEDELPERISSDEERELLALLCRVHELEAD--KVSLQAERLARQAELRRRDLQL 613
            .|    :||.|      .::.|..|.|.:       |.:.|  ::.:..|.|||.   |::.|.|
  Rat   543 LL----KKGHK------RKLESSHESEAV-------EKDEDYWEIQISPELLARG---RKKLLHL 587

  Fly   614 LRAERQRRLCEDIISSQRRLIEEGNVDLPDELRELYGLYQQ 654
            |.....|    |:.|.||  |.:....|....|||:|.:.:
  Rat   588 LNEGSAR----DLRSLQR--IGQKKAQLIVGWRELHGPFNE 622

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kif19A	NP_996208.1	Motor_domain	35..371	CDD:277568	132/346 (38%)
Kif19A	NP_996208.1	Kinesin	41..371	CDD:278646	128/340 (38%)
Kif22	NP_001009645.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33		6/16 (38%)
		KISc	38..367	CDD:214526	132/353 (37%)
		KISc_KID_like	38..358	CDD:276827	132/344 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	388..415		6/26 (23%)
		HHH_3	588..638	CDD:289597	12/41 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0242
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000448
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810