DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kif19A and Kif18a

DIOPT Version :9

Sequence 1:	NP_996208.1	Gene:	Kif19A / 41717	FlyBaseID:	FBgn0038205	Length:	750	Species:	Drosophila melanogaster
Sequence 2:	XP_006499322.1	Gene:	Kif18a / 228421	MGIID:	2446977	Length:	919	Species:	Mus musculus

Alignment Length:	783	Identity:	221/783 - (28%)
Similarity:	340/783 - (43%)	Gaps:	185/783 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 RLVVAVRVRP---SMEATERC--IEVISGGSLLYDDGGKSRPRQ--------------------- 73
            |:.|.|||||   ..:|.:.|  :.|:....|.:|      |:|
Mouse    11 RMKVVVRVRPENTKEKAVQFCKVVHVVDKHILSFD------PKQEEISFFHRKKTTNFDITKRQN 69

  Fly    74 ----YSYDHVFRENDSQEQVYKTTTAPLVRDVLNGLNAAVFAYGATGSGKTHTMLGPVPRKKPQT 134
                :.:|.||.|..:|.:|::.||.|::...|||.|..|||||||||||||||||
Mouse    70 KDLKFVFDAVFDETSTQMEVFEHTTKPILHSFLNGYNCTVFAYGATGSGKTHTMLG--------- 125

  Fly   135 SDRAPPTASCDSTDVSSQDIGLMVRAIEDIFSHI-ESAEAYSCRVSISYLEIYNELIRDLLNPGG 198
                           |:.:.|:|...:.|:|..| |..|...|..::||||:|||.|||||...|
Mouse   126 ---------------SAAEPGVMYLTMLDLFKCIDEIKEEKECSTAVSYLEVYNEQIRDLLTNSG 175

  Fly   199 PLELREDHRGQRITVAGLSEITTSSRKEVVSLLLKGNKARTMEPTAANQTSSRSHALLSIMVQ-- 261
            ||.:|||.: :.:.|.||:.....|.:|::.||..|||.||..||..|..||||||:..|.::
Mouse   176 PLAVREDSQ-KGVVVQGLTLHQPKSSEEILQLLDNGNKNRTQHPTDVNAVSSRSHAVFQIYLRQQ 239

  Fly   262 ---ARTPLGTKQGRLFLTDLAGSERAKKTKNRGKRLQEGAHINRSLLALGNVINGLSGGAR---Y 320
               |......:..::.|.||||||||..:..:|.|..||.:||:||||||||||.|:...|   :
Mouse   240 DKTASINQNVRIAKMSLIDLAGSERASVSGAKGSRFVEGTNINKSLLALGNVINALANTKRRNQH 304

  Fly   321 VNYRDSKLTRLLKEALSGRCKTVMIAHVAPESKHRDETKNTLVYADRANSITTKLQNSV-----Y 380
            :.||:||||||||::|.|.|:|:|||.|:|.|...|:|.|||.||:||..|.:.|:::|     :
Mouse   305 IPYRNSKLTRLLKDSLGGNCQTIMIAAVSPSSLFYDDTYNTLKYANRAKEIKSSLKSNVLNLNSH 369

  Fly   381 IDEFKDFPTKHYQSLVSELRDEVSRLRTKMLTERPRSGAAAAAAAAAASGSAGTAGSGAGSEAVQ 445
            |.:        |..:.:..:.|:..|:.|:.....:...:.....|               :.|.
Mouse   370 ISQ--------YVKICNMQKAEILMLKEKLKAYEEQKALSDRNDCA---------------KLVH 411

  Fly   446 EQDEQRKTELRYLREQIVLT--FKQQMKLRRKLLEAESHLLGLELDAERQHMIISHWQGRIGKLY 508
            ...|.|:||    |.|.:|.  |:.:..:|::.|:.|..|        :.:.:.|.:..:..|..
Mouse   412 SNPEDRETE----RFQEILNCLFQNREGIRQEYLKLEMLL--------KANALKSSYHQQCHKQI 464

  Fly   509 DAMGDDDIESEGSVALKNAWGELAA----IEKETRRY-KEIRE------RTEHELEQCRQKGVKL 562
            :.|..:|...:.:....:...:|..    :||:.... |:..|      |.|:|:....|.|
Mouse   465 EMMCSEDKVEKATCKRDHRLEKLKTNSCFLEKKKEEVSKQFDENTNWLHRVENEMRLLGQNG--- 526

  Fly   563 EDELPERISSDEERELLALLCRVHELEADKVSLQAERLARQAELRRRDLQLLRAERQRRLCEDII 627
              ::||.::.:       |.|....|:..::..|...:...|.|:         |:|.:..|.::
Mouse   527 --DIPEALNKE-------LHCHHLHLQNKELKTQMAHMTALACLQ---------EQQHKQTEAVL 573

  Fly   628 SS--------QRRLIEEG--NVDLPDELRELYGLYQQEIHAGVVTPSTSNYERKLPPIYTAGSDS 682
            ::        ..:|.|.|  |.....:.:::..|                .|||.   ..|.:|.
Mouse   574 NALLPVLRKQYWKLKETGLSNAAFDSDFKDIEHL----------------VERKK---VVAWADQ 619

  Fly   683 PGSSSSSEWSPASPLPQIDNQMDPVDRVMGPPVNPRLPRLSAATSANVPAGGSRRPSLRVARNPH 747
            ....|:....|...|.....|::|:..:            |..||.:.|......|..|..|...
Mouse   620 TNEHSNRNDLPGISLLMTFPQLEPIQSI------------SCCTSVSDPNVLKLTPQRRTRRKII 672

  Fly   748 PHP 750
            |.|
Mouse   673 PSP 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kif19A	NP_996208.1	Motor_domain	35..371	CDD:277568	150/374 (40%)
Kif19A	NP_996208.1	Kinesin	41..371	CDD:278646	147/368 (40%)
Kif18a	XP_006499322.1	KISc_KIP3_like	11..355	CDD:276821	150/374 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0242
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000448
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100835
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R640
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.740