DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kif19A and KIF6

DIOPT Version :9

Sequence 1:	NP_996208.1	Gene:	Kif19A / 41717	FlyBaseID:	FBgn0038205	Length:	750	Species:	Drosophila melanogaster
Sequence 2:	XP_005248961.1	Gene:	KIF6 / 221458	HGNCID:	21202	Length:	842	Species:	Homo sapiens

Alignment Length:	773	Identity:	188/773 - (24%)
Similarity:	317/773 - (41%)	Gaps:	168/773 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 EERLVVAVRVRP----------SMEATERCI---EVISGGSLLYDDG---GKSRPRQYSYDHVFR 81
            ::.:.:..||:|          |::..|:.|   |:|....|.  ||   .|....::.:..:|.
Human     3 KQTIQIFARVKPPVRKHQQGIYSIDEDEKLIPSLEIILPRDLA--DGFVNNKRESYKFKFQRIFD 65

  Fly    82 ENDSQEQVYKTTTAPLVRDVLNGLNAAVFAYGATGSGKTHTMLGPVPRKKPQTSDRAPPTASCDS 146
            ::.:||.|::....|:...||.|.|..:||||.||||||.|:.|...|    .|||
Human    66 QDANQETVFENIAKPVAGSVLAGYNGTIFAYGQTGSGKTFTITGGAER----YSDR--------- 117

  Fly   147 TDVSSQDIGLMVRAIEDIFSHIESAEAYSCRVSISYLEIYNELIRDLLNPGGPLELRED------ 205
                    |::.|.:..||..::...:......|||||||||...|||:|.......||
Human   118 --------GIIPRTLSYIFEQLQKDSSKIYTTHISYLEIYNECGYDLLDPRHEASSLEDLPKVTI 174

  Fly   206 --HRGQRITVAGLSEITTSSRKEVVSLLLKGNKARTMEPTAANQTSSRSHALLSIMVQARTP--L 266
              ...|.|.:..|:....::.:|.::||..|:..|.:..|..||.|:|||.:.:|.:.::.|  .
Human   175 LEDPDQNIHLKNLTLHQATTEEEALNLLFLGDTNRMIAETPMNQASTRSHCIFTIHLSSKEPGSA 239

  Fly   267 GTKQGRLFLTDLAGSERAKKTKNRGKRLQEGAHINRSLLALGNVINGLSGGAR-YVNYRDSKLTR 330
            ..:..:|.|.|||||||..||...|..|.|..:||.||..|..||..||...| ::.||:|.:|.
Human   240 TVRHAKLHLVDLAGSERVAKTGVGGHLLTEAKYINLSLHYLEQVIIALSEKHRSHIPYRNSMMTS 304

  Fly   331 LLKEALSGRCKTVMIAHVAPESKHRDETKNTLVYADRANSITTKLQNSVYIDEFKD--FPTKHYQ 393
            :|:::|.|.|.|.|||.::.|.::.||:.:|..:|.|    ...::|...::|..:  ...|..|
Human   305 VLRDSLGGNCMTTMIATLSLEKRNLDESISTCRFAQR----VALIKNEAVLNEEINPRLVIKRLQ 365

  Fly   394 SLVSELRDEVSRL----RTKMLTE---------------------RPRSGAAAAAAAAAASG--- 430
            ..:.||:||::.:    ||:.|||                     |...||...........
Human   366 KEIQELKDELAMVTGEQRTEALTEAELLQLEKLITSFLEDQDSDSRLEVGADMRKVHHCFHHLKK 430

  Fly   431 --------SAGTAGSGAGSEAVQE---QDEQRK-TELRYLREQIVLTFKQQMKLRRKLLEAESHL 483
                    ...|..|.:..:..||   ::|.|| .::...|:..:......:|..:|..:...||
Human   431 LLNDKKILENNTVSSESKDQDCQEPLKEEEYRKLRDILKQRDNEINILVNMLKKEKKKAQEALHL 495

  Fly   484 LGLEL---------------DAERQHMIISHWQGR------IGK----LYDAMGDDDIESEGSVA 523
            .|::.               ..|.|.|.:|....:      :||    |:..:|   :..|.|:.
Human   496 AGMDRREFRQSQSPPFRLGNPEEGQRMRLSSAPSQAQDFSILGKRSSLLHKKIG---MREEMSLG 557

  Fly   524 LKNAW-------GELAAIEKE----TRRYKEIRERTEHELEQCRQKGVKLEDELPER-------- 569
            .:.|:       .:...|:..    .:|:.|.:...| .:.:.|.|...|::|:.:|
Human   558 CQEAFEIFKRDHADSVTIDDNKQILKQRFSEAKALGE-SINEARSKIGHLKEEITQRHIQQVALG 621

  Fly   570 ISSDEERELLALLCRVHELEADKVSLQAERLARQAELRRRDLQLLRAERQRRLCEDIISSQRRLI 634
            ||.:....|:.      :.:.:|:..|.|...|:.:.....|:.|:.|         |...:.|:
Human   622 ISENMAVPLMP------DQQEEKLRSQLEEEKRRYKTMFTRLKALKVE---------IEHLQLLM 671

  Fly   635 EEGNVDLPDELRELYGLYQQEIHAGVVTPSTSNYERKLPPIYTAGSDSPGSSSSSEWS 692
            ::..|.|..|....:.  ::..:..|.:|:.::.:...|.:.|       |.|..|||
Human   672 DKAKVKLQKEFEVWWA--EEATNLQVNSPAVNSLDHTKPFLQT-------SDSQHEWS 720

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kif19A	NP_996208.1	Motor_domain	35..371	CDD:277568	115/362 (32%)
Kif19A	NP_996208.1	Kinesin	41..371	CDD:278646	115/356 (32%)
KIF6	XP_005248961.1	Motor_domain	5..343	CDD:277568	115/364 (32%)
KIF6	XP_005248961.1	Kinesin	11..345	CDD:278646	115/360 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0242
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810