Protein Alignment Kif19A and Kif1c

DIOPT Version :10

• Sequence 1: NP_996208.1
• Gene: Kif19A / 41717
• FlyBaseID: FBgn0038205
• Length: 750
• Species: Drosophila melanogaster
• Sequence 2: NP_665884.2
• Gene: Kif1c / 113886
• RGDID: 70928
• Length: 1100
• Species: Rattus norvegicus
• Alignment Length: 824
• Identity: 221/824 - (26%)
• Similarity: 358/824 - (43%)
• Gaps: 217/824 - (26%)

  Fly    38 VAVRVRP------SMEATERCIEVISGG--SLLYDDGGKSRPRQYSYDHVFREND--------SQ 86
            |||||||      |.:|  :|:..:.|.  |::.....|..|:.:::|:.:..:.        ||
  Rat     8 VAVRVRPFNARETSQDA--KCVVSMQGNTTSIINPKQSKDAPKSFTFDYSYWSHTSVEDPQFASQ 70

  Fly    87 EQVYKTTTAPLVRDVLNGLNAAVFAYGATGSGKTHTMLGPVPRKKPQTSDRAPPTASCDSTDVSS 151
            :|||:.....::.....|.|..:||||.||:||::||:|   |::|...
  Rat    71 QQVYRDIGEEMLLHAFEGYNVCIFAYGQTGAGKSYTMMG---RQEPGQQ---------------- 116

  Fly   152 QDIGLMVRAIEDIFSHI---ESAE-AYSCRVSISYLEIYNELIRDLLNP--GGPLELREDHRGQR 210
               |::.:..||:||.:   :||: :||  |.:||:|||.|.:||||||  .|.|.:|| |....
  Rat   117 ---GIVPQLCEDLFSRVNVNQSAQLSYS--VEVSYMEIYCERVRDLLNPKSRGSLRVRE-HPILG 175

  Fly   211 ITVAGLSEITTSSRKEVVSLLLKGNKARTMEPTAANQTSSRSHALLSIMVQAR-----TPLGT-K 269
            ..|..||::..:|..::..|:..||||||:..|..|:|||||||:.:|:...|     |.|.: |
  Rat   176 PYVQDLSKLAVTSYADIADLMDCGNKARTVAATNMNETSSRSHAVFTIVFTQRSHDQLTGLDSEK 240

  Fly   270 QGRLFLTDLAGSERAKKTKNRGKRLQEGAHINRSLLALGNVINGLSG------GARYVNYRDSKL 328
            ..::.|.||||||||..:..||.||:|||:||:||..||.||:.|:.      .:.::.||||.|
  Rat   241 VSKISLVDLAGSERADSSGARGMRLKEGANINKSLTTLGKVISALADLQSKKRKSDFIPYRDSVL 305

  Fly   329 TRLLKEALSGRCKTVMIAHVAPESKHRDETKNTLVYADRANSITTKLQNSVYIDEFKDFPTKHYQ 393
            |.||||.|.|..:|.|||.::|...:.:||.:||.||||    |.:::.:..|:|..:      .
  Rat   306 TWLLKENLGGNSRTAMIAALSPADINYEETLSTLRYADR----TKQIRCNAVINEDPN------A 360

  Fly   394 SLVSELRDEVSRLRTKMLTERPRSGA----------------AAAAAAAAASGSAGTAGSG---- 438
            .|:.||::||:|||..::.:...:.|                ||::..|.||.|:....:|
  Rat   361 RLIRELQEEVARLRELLMAQGLSASALGGLKVEEGSPGGVLPAASSPPAPASPSSPPPHNGELEP 425

  Fly   439 ---------AGSEAVQEQDEQRKTELRYLRE--QIVLTFKQQMKLRRKLLEAE------------ 480
                     .|.|...|:.::.:..:..|.|  :..|...:.:::.|:.|.||
  Rat   426 SFSPSAEPQIGPEEAMERLQETEKIIAELNETWEEKLRKTEALRMEREALLAEMGVAVREDGGTV 490

  Fly   481 --------SHLLGLELDAERQHMIISHWQG---RIGKLYDAMGDDDIESEGSVALKNAWGELAAI 534
                    .||:.|..|......::.|.:.   |:|::     |.||:..|..
  Rat   491 GVFSPKKTPHLVNLNEDPLMSECLLYHIKDGVTRVGQV-----DVDIKLTGQF------------ 538

  Fly   535 EKETRRYKEIRERTEHELEQCRQKGVKLEDELPERISSDEERELLALL--CRVHE------LEAD 591
                     |||      :.|..:.:...|           .|::..|  |...|      |..:
  Rat   539 ---------IRE------QHCLFRSIPQPD-----------GEVMVTLEPCEGAETYVNGKLVTE 577

  Fly   592 KVSLQAER---LARQAELRRRDLQLLRAERQRRLCE---------DIISSQRRLIEEGNVDLPDE 644
            .:.|::..   :.:....|....:..|.||:|.:..         |...:|:.|:|:..:|:..|
  Rat   578 PLVLKSGNRIVMGKNHVFRFNHPEQARLERERGVPPPPGPPSEPVDWNFAQKELLEQQGIDIKLE 642

  Fly   645 ----LRELYGLYQQEIHAGVVTPSTSNYERKLPPIYTAGSDSPGSSSSSEWSPASPLPQIDNQMD 705
                |::|...|::|.....:...    :::|.....:|.||...|....|...|.|.:
  Rat   643 MEKRLQDLENQYRKEKEEADLLLE----QQRLYADSDSGEDSDKRSCEESWRLISSLRE------ 697

  Fly   706 PVDRVMGPPVNPRLPRLSAAT---SANVPAGGSRRPSLRVARNP 746
                        :||..:..|   ...:|:.|.||...||.:.|
  Rat   698 ------------QLPPNTVQTIVKRCGLPSSGKRRAPRRVYQIP 729

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kif19A	NP_996208.1	Motor_domain	35..371	CDD:473979	137/366 (37%)
		SMC_prok_B	<393..672	CDD:274008	63/356 (18%)
Kif1c	NP_665884.2	KISc_KIF1A_KIF1B	4..355	CDD:276816	138/377 (37%)
		Kinesin_assoc	352..522	CDD:465047	33/175 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	398..435		7/36 (19%)
		FHA_KIF1C	498..599	CDD:438780	23/143 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	900..924
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	949..1100