DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kif19A and Kif22

DIOPT Version :9

Sequence 1:	NP_996208.1	Gene:	Kif19A / 41717	FlyBaseID:	FBgn0038205	Length:	750	Species:	Drosophila melanogaster
Sequence 2:	XP_006507264.1	Gene:	Kif22 / 110033	MGIID:	109233	Length:	690	Species:	Mus musculus

Alignment Length:	806	Identity:	223/806 - (27%)
Similarity:	350/806 - (43%)	Gaps:	191/806 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 AGASSWSG---SSGGSNSSQGRSIATAQPAQEERLVVAVRVRPSM----EATE-RCIEVISGGSL 61
            |.|:|..|   |.||    .||....|      |:.||||:||.|    ||.| .|:..|...||
Mouse    15 ASATSGPGRCVSKGG----LGRRPPLA------RVRVAVRLRPFMDGETEAKELPCVRAIDSCSL 69

  Fly    62 LYDDGGK-SRPRQYSYDHVFRENDSQEQVYKTTTAPLVRDVLNGLNAAVFAYGATGSGKTHTMLG 125
            ...:..| ....:|.:|..:.|..:|::||..:..|::|.:|.|.||:|.|||.||:||||||||
Mouse    70 EVANWKKYQETLKYQFDAFYGEKSTQQEVYVGSVQPILRHLLEGQNASVLAYGPTGAGKTHTMLG 134

  Fly   126 PVPRKKPQTSDRAPPTASCDSTDVSSQDIGLMVRAIEDI--FSHIESAEA--YSCRVSISYLEIY 186
                                    |.:..|::.||:.|:  .:..||||.  :...|::||||||
Mouse   135 ------------------------SPEQPGVIPRALMDLLQLAREESAEGRPWDVSVAMSYLEIY 175

  Fly   187 NELIRDLLNP-GGPLELREDHRGQRITVAGLSEITTSSRKEVVSLLLKGNKARTMEPTAANQTSS 250
            .|.:.|||:| .|.|.:|||.|| .|.:.||::...:|..:.....|..::.|.:..|..||.||
Mouse   176 QEKVLDLLDPASGDLVIREDCRG-NILIPGLTQKPITSFSDFEQHFLPASRNRAVGATRLNQRSS 239

  Fly   251 RSHALLSIMVQAR---TPLGTKQGRLFLTDLAGSERAKKTKNRGKRLQEGAHINRSLLALGNVIN 312
            ||||:|.:.|..|   ||...::|:|:|.||||||..::|.|:|.||:|...||.||..||.|::
Mouse   240 RSHAVLLVKVDQRERLTPFRQREGKLYLIDLAGSEDNRRTGNQGIRLKESGAINTSLFVLGKVVD 304

  Fly   313 GLSGGARYVNYRDSKLTRLLKEALSGRCKTVMIAHVAPESKHRDETKNTLVYADRANSITTKLQN 377
            .|:.|...:.||||||||||:::|.|...:::||::|||.:...:|.:.|.:..|:..:..:...
Mouse   305 ALNQGLPRIPYRDSKLTRLLQDSLGGSAHSILIANIAPERRFYQDTISALNFTARSKEVINRPFT 369

  Fly   378 SVYIDEFKDFPTKHYQ-SLVSELRDEVSRLRTKMLTERPRSGAAAAAAAAAAS------------ 429
            :..:......|.|..| .|:.....:.::...:..|..|.|.||.|:|:...|
Mouse   370 NESLQPHALAPVKLSQKELLGPSEAKKAKGPEEESTGSPESTAAPASASQKLSLLQKLSNMDPAM 434

  Fly   430 -----------GSAGTAGSGAGSEAVQEQ------DEQRKTELRYLREQIVLTFKQQMKLRRKLL 477
                       ||.|:.|:...:...:|:      .|::..|:            :::|:::|.|
Mouse   435 LENLLSMERLLGSQGSQGTPLLNTPKRERMVLMKTVEEKNLEI------------ERLKMKQKEL 487

  Fly   478 EAESHLLGLEL----DAERQHMII---SHWQGRIGKLYDAMGDDDIESEGSVALKNAWGELAAIE 535
            ||:  :|..|.    :.|....|:   :.:.|.:.|                .||.      |:.
Mouse   488 EAK--VLAQEAPDPREKENTPTILQPPASYSGTVAK----------------PLKK------AVV 528

  Fly   536 KETRRYKEIRERTEHELEQCRQKGVKLEDELPERISSDEERELLALLCRVHELEAD--KVSLQAE 598
            ...:|.::.||.:..  .|..:||.|      .::....|.|.:       |.:.|  :|.:..|
Mouse   529 MPLQRIQKQRESSNQ--IQLLKKGPK------RKLEPSPESEAV-------EKDEDYWEVQISPE 578

  Fly   599 RLARQAELRRRDLQLLRAERQRRLCEDIISSQRRLIEEGNVDLPDELRELYGLYQQ----EIHAG 659
            .||..   |::.|.||.....|    ::.|.||  |.:....|....|||:|.:.:    |...|
Mouse   579 LLAHG---RKKLLDLLNEGSAR----ELRSLQR--IGQKKAQLIVGWRELHGPFSEVEDLEQVEG 634

  Fly   660 VVTPSTSNYERKLPPIYTAGSDSPGSSSSSEWSPASPLPQIDNQMDPVDRVMGPPVNPRLPRLSA 724
            :......::.:..|                      |||.:...         ||..|.|...:.
Mouse   635 ISGKQVESFLKVRP----------------------PLPFLHGV---------PPPQPTLGCYAN 668

  Fly   725 ATSANVPAGGSRRPSLRVARNPHPHP 750
            |.|:::.|.     .|.:|.:.|..|
Mouse   669 ARSSSLQAN-----LLSLAASQHSGP 689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kif19A	NP_996208.1	Motor_domain	35..371	CDD:277568	134/349 (38%)
Kif19A	NP_996208.1	Kinesin	41..371	CDD:278646	130/343 (38%)
Kif22	XP_006507264.1	KISc_KID_like	38..361	CDD:276827	134/347 (39%)
Kif22	XP_006507264.1	ComEA	<591..641	CDD:393460	13/55 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0242
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000448
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810