Protein Alignment Kif19A and kif14

DIOPT Version :10

• Sequence 1: NP_996208.1
• Gene: Kif19A / 41717
• FlyBaseID: FBgn0038205
• Length: 750
• Species: Drosophila melanogaster
• Sequence 2: XP_004913798.2
• Gene: kif14 / 100493263
• XenbaseID: XB-GENE-981231
• Length: 1609
• Species: Xenopus tropicalis
• Alignment Length: 929
• Identity: 229/929 - (24%)
• Similarity: 366/929 - (39%)
• Gaps: 288/929 - (31%)

  Fly     1 MATSAGASSWSGSSGGSNSSQGRSIATA---------QP----------AQEER-------LVVA 39
            :||...:...:.|:.||..| |||..:|         ||          .:||.       :.||
 Frog   287 VATLPASQKKNSSTPGSVYS-GRSEKSADVCLSSDEIQPKGDTAFSNFNLEEEHFKAENCAVTVA 350

  Fly    40 VRVRP--SMEATERCIEVI--SGGSLLYDDGGKSRPRQYSYDHVFREND-------SQEQVYKTT 93
            |||||  ..|..|:.::|:  :|...........:...:.||..|...:       .|..||:..
 Frog   351 VRVRPFSKREVNEKAVQVVFMNGQETTVQHPDSKQNYIFCYDFSFWSFEKSQPSFVGQASVYEKL 415

  Fly    94 TAPLVRDVLNGLNAAVFAYGATGSGKTHTMLGPVPRKKPQTSDRAPPTASCDSTDVSSQDIGLMV 158
            ..||:...|.|.|..:||||.|||||::||:|         .|..|               |::.
 Frog   416 AVPLLEWSLLGYNTCLFAYGQTGSGKSYTMMG---------FDGEP---------------GIIP 456

  Fly   159 RAIEDIFSHIESA--EAYSCRVSISYLEIYNELIRDLL-------NPGGPLELREDHRGQRITVA 214
            |...|:||.|::.  :..|..:.|||.|:|||.|.|||       ....||::|| |......|.
 Frog   457 RFCSDLFSRIQATMKQKLSFHLEISYFEVYNEKIHDLLIFKAENGQKKQPLKVRE-HPLTGPYVE 520

  Fly   215 GLSEITTSSRKEVVSLLLKGNKARTMEPTAANQTSSRSHALLS-IMVQARTPLGTKQ-------G 271
            .||....||.:::.|.|..|||.|....|..|..|||||::.: :|.|.:|.....|       .
 Frog   521 DLSMNVVSSFQDIQSWLELGNKQRATAATGMNDKSSRSHSVFTLVMTQTKTEYVDGQEHDHRITS 585

  Fly   272 RLFLTDLAGSERAKKTKNRGKRLQEGAHINRSLLALGNVINGLSGGAR-----YVNYRDSKLTRL 331
            |:.|.|||||||....:..|:||:||..||:|||.||.||:.||..::     ::.||:|.||.|
 Frog   586 RINLVDLAGSERCSTAQTSGERLKEGVSINKSLLTLGKVISALSENSQTRKKTFIPYRESVLTWL 650

  Fly   332 LKEALSGRCKTVMIAHVAPESKHRDETKNTLVYADRANSITTKLQNSVYIDEFKDFPTKHYQSLV 396
            |||:|.|..||.|||.::|.:.:.:||.:||.||.:|..|.    |...::|  |...|    ::
 Frog   651 LKESLGGNSKTSMIATISPAATNMEETLSTLRYAKQARLII----NVAKVNE--DLNAK----II 705

  Fly   397 SELRDEVSRLRTKMLTERPRSG---------AAAAAAAAAASGSAGTAGSGAGSEAVQEQDEQRK 452
            .||:.|:.:::...|:.:.:..         ..:............:....|..:.:::.::::|
 Frog   706 RELKAEIEKMKASQLSAKNKDSEKYRQCHQEVTSLKLKLCQQEREMSELRRAWKDKLEQAEQRKK 770

  Fly   453 TELRYLREQIVLTFKQQMKLRRKLLEAESHLLGLELDAERQHMI---ISHWQGRIGKLYDAMGDD 514
            .|::.| ::..:|||...:|        .:|:.|..|.:...|:   |...|..:|| |.|....
 Frog   771 VEMQEL-QKAGITFKMDNRL--------PNLVNLNEDPQLSEMLLYMIKEGQTTVGK-YKAGSSH 825

  Fly   515 DIESEGS---------------VALK--------------------------------------- 525
            ||:..|:               |.:|
 Frog   826 DIQLSGALIAEDHCIITNNENIVCIKPFGDAKTYVNGNQISGSTILHHGDRLILGGDHYFRVNHP 890

  Fly   526 ------NAWGELAAIEKETRRYK-EI----RERTEHELEQCR-------QKGVKLEDELPERISS 572
                  ||..:::...|:....| |:    |.:...|:|:.|       .:|:::..|:.::..:
 Frog   891 MEVNRLNATTQVSDGPKDYEFAKNELLSAQRSQLAEEIEEARLRAKEEMMEGIQIAKEMAQQELT 955

  Fly   573 DEE-------RELLALL------------------CRVHELEADKVSLQ-----------AERLA 601
            .::       |:|.|.|                  .|:.|||..|:.||           .|.||
 Frog   956 SQKFAYEEKIRDLEAQLKKESQHKELQEMNSQRATTRIQELEEMKIHLQQEVQFNKKRLEMETLA 1020

  Fly   602 RQAELRRRD------LQLLRAERQRRLCEDIISSQRR---------------------LIEEGNV 639
            .:..|...:      ||.|.||:| ::.:::...||.                     :|:|.|
 Frog  1021 TKQALEDHNVRHAKILQALEAEKQ-KIAKEVQMLQRERNSQDRAMAVQPTWNNMKLSVMIQEAN- 1083

  Fly   640 DLPDELRE--LYGLYQ----------------QEIHAGVVTP-STSNYERKL---PPIY-----T 677
            .:..:|::  ::..:.                :.:..|:||. |...:|.||   ..:|     |
 Frog  1084 SISSKLKKHTVFSRHDVTDKENLPTNPVQIQVKNLKLGIVTYWSLEKFEYKLAAMKDLYENHGST 1148

  Fly   678 AGSD---SPGSSSSSEWSP 693
            ...|   .||    .||.|
 Frog  1149 KDDDVFYDPG----DEWEP 1163

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kif19A	NP_996208.1	Motor_domain	35..371	CDD:473979	130/375 (35%)
		SMC_prok_B	<393..672	CDD:274008	70/444 (16%)
kif14	XP_004913798.2	KISc_KIF1A_KIF1B	347..697	CDD:276816	132/378 (35%)
		Kinesin_assoc	694..812	CDD:465047	20/132 (15%)
		FHA_KIF14	783..890	CDD:438759	18/115 (16%)
		Smc	<912..>1063	CDD:440809	31/151 (21%)