Protein Alignment Kif19A and kif18b

DIOPT Version :10

• Sequence 1: NP_996208.1
• Gene: Kif19A / 41717
• FlyBaseID: FBgn0038205
• Length: 750
• Species: Drosophila melanogaster
• Sequence 2: XP_002939283.3
• Gene: kif18b / 100490953
• XenbaseID: XB-GENE-5960389
• Length: 872
• Species: Xenopus tropicalis
• Alignment Length: 777
• Identity: 241/777 - (31%)
• Similarity: 361/777 - (46%)
• Gaps: 153/777 - (19%)

  Fly    27 TAQPAQEERLVVAVRVRPSMEATER-----CIEVISGGSLLYD----------------DGGKSR 70
            ||...:|..:.|.|||||..:..:.     .::|:....|::|                ||.|.:
 Frog     4 TASSTEEGNVSVVVRVRPPNQREQEGNHHAVVQVVDHNMLVFDPDEPETTGVFSSLRGNDGPKRK 68

  Fly    71 PR--QYSYDHVFRENDSQEQVYKTTTAPLVRDVLNGLNAAVFAYGATGSGKTHTMLGPVPRKKPQ 133
            .:  ::.:|.:|.||..|:.|::.||..::..||||.|.:||||||||:||||||||
 Frog    69 GKDMKFIFDRIFGENSRQQDVFEHTTKEILDGVLNGYNCSVFAYGATGAGKTHTMLG-------- 125

  Fly   134 TSDRAPPTASCDSTDVSSQDIGLMVRAIEDIFSHIES-AEAYSCRVSISYLEIYNELIRDLLNPG 197
                            |..|.|:|...:.:::..||: .|..||.|.|||||:|||.|:|||.|.
 Frog   126 ----------------SEADPGVMYLTMVELYRRIEAIKEEKSCEVLISYLEVYNEQIQDLLEPR 174

  Fly   198 GPLELREDHRGQRITVAGLSEITTSSRKEVVSLLLKGNKARTMEPTAANQTSSRSHALLSIMV-- 260
            |.|.:|||.: :.:.|.|||.....|..:::.:|..||..||..||.||.:||.|||:..|.|
 Frog   175 GSLAIREDPQ-KGVVVQGLSFHQPKSADQLLQMLASGNLNRTQHPTDANASSSHSHAVFQIYVKQ 238

  Fly   261 QART---PLGTKQGRLFLTDLAGSERAKKTKNRGKRLQEGAHINRSLLALGNVINGLSGG---AR 319
            |.||   ....:..::.|.||||||||..|..:|:||:|||:||||||||.||||.|:..   ..
 Frog   239 QDRTVSISQDVRVAKMSLIDLAGSERASTTNAKGERLREGANINRSLLALINVINALADAKSKKA 303

  Fly   320 YVNYRDSKLTRLLKEALSGRCKTVMIAHVAPESKHRDETKNTLVYADRANSITTKLQNSVYIDEF 384
            ::.|||||||||||:::.|.|:|||||.::|.:...|:|.|||.||:||..|...::::|.   .
 Frog   304 HIPYRDSKLTRLLKDSIGGNCRTVMIAAISPSALSYDDTYNTLKYANRAKEIKLSMKSNVI---N 365

  Fly   385 KDFPTKHYQSLVSELRDEVSRLRTKM----LTERPRSGAAAAAAAAAAS---------GSAGTAG 436
            .|.....|.::..||:.||:.||.|:    :.|:|....:..:.....|         ||. ..|
 Frog   366 LDCHISKYAAVCEELKAEVAELREKLRFYEMKEQPDDDTSDNSLQDKTSPRREEHSDLGSP-EQG 429

  Fly   437 SGA---GSEAVQEQDEQRKTELRYLR-EQIVLTFKQQMKLRRKLLE-------------AESHLL 484
            |||   .:.:.|.|| .:..|:...: :|:.|    ...|.|:.||             ||..:.
 Frog   430 SGALLLSTSSCQSQD-HKPAEMNPRKWDQVPL----NCSLGREELEKNPCLHEALKDDAAERLVT 489

  Fly   485 GLELDAERQHMIISHWQGRIGKLYDAMGDDDIESEGSVALKNAWGELAAIEKETRRYKEIRERTE 549
            .|.....:|..|:     ::..||....:|::.....:||:   |:.|..||.|.: :::.|  |
 Frog   490 SLLNFVRKQCEIL-----KLAGLYTPELEDELRQLEGLALR---GQKATAEKVTEK-EQVTE--E 543

  Fly   550 HELEQCRQKGVKLEDELPERISSDEERELLALLCRVHELEADKVSLQAERLARQAELRRRDLQLL 614
            ||:|..:::....:..|.|.:..|.:.|::          .|.|....:|  :..:..|.|   :
 Frog   544 HEMETHKEQEEVPQTPLVEDVVFDIKEEVI----------EDPVPPARKR--KPGKRYRAD---I 593

  Fly   615 RAERQRRLCEDIISSQRRLIEEGNVDLPDELRELYGLYQQEIHAGVVTPSTSNYERKLPPIYTAG 679
            ..:....|...|:..:||             ||......:...|||  |||...:.|.|    ..
 Frog   594 LPDNSPSLRSPIVPVKRR-------------REATNTPTKARLAGV--PSTPEVQVKRP----RK 639

  Fly   680 SDSPGSSSSSEWSPASPLPQIDNQMDPVDRVMGPPVNPRLPRLSA------ATSANVPAGGS 735
            |..|.....|..|..:.||  .|..|    :...|.:...|:.:|      .|.:.:|.|.|
 Frog   640 SSIPSRCRVSLRSSLNLLP--SNAKD----IASQPPSLCTPKQTAKIQSQTVTKSRMPLGTS 695

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kif19A	NP_996208.1	Motor_domain	35..371	CDD:473979	150/367 (41%)
		SMC_prok_B	<393..672	CDD:274008	67/308 (22%)
kif18b	XP_002939283.3	KISc_KIP3_like	23..355	CDD:276821	144/356 (40%)