Protein Alignment Kif19A and kif3ca

DIOPT Version :10

• Sequence 1: NP_996208.1
• Gene: Kif19A / 41717
• FlyBaseID: FBgn0038205
• Length: 750
• Species: Drosophila melanogaster
• Sequence 2: XP_002661420.3
• Gene: kif3ca / 100333558
• ZFINID: ZDB-GENE-111214-2
• Length: 754
• Species: Danio rerio
• Alignment Length: 750
• Identity: 219/750 - (29%)
• Similarity: 346/750 - (46%)
• Gaps: 155/750 - (20%)

  Fly    34 ERLVVAVRVRPSMEATERC-------IEVISGGSLLYDDGGKSRP----RQYSYDHVFRENDSQE 87
            |.:.|.||.||.....|..       ::|..|...|.:  .|:.|    :.:::|.|:.|...|.
Zfish     9 ESVKVVVRCRPLNRKEESSGYENIVQMDVKLGQVALRN--AKAGPGDLLKTFTFDAVYDECSKQG 71

  Fly    88 QVYKTTTAPLVRDVLNGLNAAVFAYGATGSGKTHTMLGPVPRKKPQTSDRAPPTASCDSTDVSSQ 152
            .:|..|..||:..||.|.|..:||||.||:|||:||.|       |..|              ::
Zfish    72 DLYDETVRPLIDSVLRGFNGTIFAYGQTGTGKTYTMQG-------QWLD--------------AE 115

  Fly   153 DIGLMVRAIEDIFSHIESAEAYSCRVSISYLEIYNELIRDLL--NPGGPLELREDHRGQRITVAG 215
            ..|::..:.|.||:||..::.....|..||||||.|.|||||  :....|||:|. ....:.:..
Zfish   116 RRGIIPNSFEHIFTHISRSQNQQYLVRASYLEIYQEEIRDLLTKDHSKKLELKES-ADSGVYIKD 179

  Fly   216 LSEITTSSRKEVVSLLLKGNKARTMEPTAANQTSSRSHALLSIMVQARTPLG------TKQGRLF 274
            ||...|.:.||:..::..||:.|::..|..|:.||||||:..|.|:. :.||      .:.|:|.
Zfish   180 LSSFVTKNVKEIEHVMNVGNQTRSVGFTNMNEHSSRSHAIFIITVEC-SQLGPDGQNHIRVGKLN 243

  Fly   275 LTDLAGSERAKKTKNRGKRLQEGAHINRSLLALGNVINGL-SGGARYVNYRDSKLTRLLKEALSG 338
            |.|||||||..||..:|:||:|...||.||.||||||:.| .|.:.:|.||||||||||:::|.|
Zfish   244 LVDLAGSERQTKTGVQGERLKEATKINLSLSALGNVISALVDGRSSHVPYRDSKLTRLLQDSLGG 308

  Fly   339 RCKTVMIAHVAPESKHRDETKNTLVYADRANSITTKLQNSVYIDEFKDFPTKHYQSLVSELRDEV 403
            ..||:|:|.:.|.|.:.:||..||.||:||.:|..|.:.:   ::.||       :|:.|.::|:
Zfish   309 NAKTIMVATLGPASYNYEETLTTLRYANRAKNIKNKPRVN---EDPKD-------ALLREFQEEI 363

  Fly   404 SRLRTK-----MLTERPRSGAAAAAAAAAASGSAGTAGSGAGSEAVQEQDE---------QRKTE 454
            :||:.:     |||:|.|.......               .|.|.|:|:|:         ..|..
Zfish   364 ARLKAQLDKRGMLTKRKRRSRRLRK---------------IGEEEVEEEDDLEDYDDEEIVEKEA 413

  Fly   455 LRYLREQIVLTFKQQMKLR----------RKLLEAESHLL-GLELDAERQHMIISHWQGRIGKLY 508
            ..|::||.....:::..:|          ::|||.:..:: .|:.:.|...|:.:.::.
Zfish   414 QEYMKEQQEELEREKEAIRDDHSLVAEEKQRLLEEKERMMRHLKKEQEATEMLTAKFKA------ 472

  Fly   509 DAMGDDDIESEGSVALKNAWGELAAIEKETRRYKEIRERTEHEL-EQCRQKGVKLEDELPERISS 572
                   :||:..|..||       |...|...:::.|:..||: ||.|:     |.|:.:::..
Zfish   473 -------MESKLLVGGKN-------IIDHTNEQQKMLEQKRHEIAEQTRR-----EREIQQQLLD 518

  Fly   573 DEERELLALLCRVHELEADKVSLQAERLARQAELRR--RDLQLLRAERQRRLCEDIISSQRRLIE 635
            .:|..|        ||.....|||.|..|:..:|::  ..||.|:|:.|....|.:.|  |:.:|
Zfish   519 QDEETL--------ELRETFSSLQQEVEAKTKKLKKLYAKLQSLKADIQDVNDEHVRS--RQDLE 573

  Fly   636 EGNVDLPDELRELYGLYQQEIHAGVVTPSTSN-YERKLPPIYTAGSDSPGSSSSSEWSPASPLPQ 699
            :...:|..||:..|.:.:     ..:.|...| ...:|.  :.|..|        :|. ..||..
Zfish   574 QTQNELTRELKFKYLIIE-----NFIPPEEKNKIMNRLE--FDAEED--------QWK-FQPLVP 622

  Fly   700 IDNQMDPVDRVMGPPVNPRLP-----RLSAATSAN 729
            .:|:...:.|.....|..:.|     |::.|..|:
Zfish   623 AENKFTQMKRRPASAVGYKRPISQYARVAMAMGAH 657

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kif19A	NP_996208.1	Motor_domain	35..371	CDD:473979	135/355 (38%)
		SMC_prok_B	<393..672	CDD:274008	66/307 (21%)
kif3ca	XP_002661420.3	KISc_KIF3	9..341	CDD:276822	136/356 (38%)
		Smc	<408..>584	CDD:440809	47/210 (22%)