DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12402 and GRR1

DIOPT Version :9

Sequence 1:	NP_001303481.1	Gene:	CG12402 / 41714	FlyBaseID:	FBgn0038202	Length:	671	Species:	Drosophila melanogaster
Sequence 2:	NP_012623.1	Gene:	GRR1 / 853552	SGDID:	S000003850	Length:	1151	Species:	Saccharomyces cerevisiae

Alignment Length:	565	Identity:	120/565 - (21%)
Similarity:	226/565 - (40%)	Gaps:	139/565 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 HNLEAIHKHAKGGNCYLSFERIELRNLRQCRQLENFLRLVGHEVK------HLQVRHAPVFRNLD 183
            |.|:.:...|      |..|.:|:||||.     ..|.::....|      |.::|...|....|
Yeast   207 HKLQRMRLRA------LETENMEIRNLRL-----KILTIIEEYKKSLYAYCHSKLRGQQVENPTD 260

  Fly   184 GKLPNLKVLTIATTMSMDDQHLAAMDDLD--MKQFSHLVGFE------CDGVS-LDAVLKMRMLL 239
            ..:  :.:.:|.||.|.|.:.  .:.||.  .:||.:.|...      |..|: ...|..:.||
Yeast   261 NFI--IWINSIDTTESSDLKE--GLQDLSRYSRQFINNVLSNPSNQNICTSVTRRSPVFALNML- 320

  Fly   240 QLRRTENKVQLRHLQFEFRRNNEN----ALLDVLQDHAETLVCVNLFFSCSPGIDTREWCRAFEN 300
                   ..::.||..:  :.|:.    ..|.|.:..||.:|.: |::  .|.|:.:.....|
Yeast   321 -------PSEILHLILD--KLNQKYDIVKFLTVSKLWAEIIVKI-LYY--RPHINKKSQLDLF-- 371

  Fly   301 MHNLRTLKLSG-----NCHLVL-------------------------LEAV-------LRAVPES 328
               |||:||:.     |..|::                         ||.:       :.:||.|
Yeast   372 ---LRTMKLTSEETVFNYRLMIKRLNFSFVGDYMHDTELNYFVGCKNLERLTLVFCKHITSVPIS 433

  Fly   329 APIR------QLDLTGMLSLTNELL------------LYVAGKWQST-------------LKVLD 362
            |.:|      .:|:||:..:::::.            .||......|             ||.:.
Yeast   434 AVLRGCKFLQSVDITGIRDVSDDVFDTLATYCPRVQGFYVPQARNVTFDSLRNFIVHSPMLKRIK 498

  Fly   363 LMFCVQLNANCIDALRQLSGRLEALTMAYCRELTGTGLLQGLAGDINYSLQELHLEETIFLDES- 426
            :.....:|...::.|......|..:.:.....:|.:.||:.|...:  .|:|..:.....:.::
Yeast   499 ITANNNMNDELVELLANKCPLLVEVDITLSPNVTDSSLLKLLTRLV--QLREFRITHNTNITDNL 561

  Fly   427 --SMCQLLERLPNLRRLSLDNCRQAVTDRTMATICQYQTRLRNLNIEYCMKITDQGLMGYGDTPY 489
              .:.::::.:|:||.:.|..| :.:||:|:.:|.....:|||:.:..|.:|||..|       :
Yeast   562 FQELSKVVDDMPSLRLIDLSGC-ENITDKTIESIVNLAPKLRNVFLGKCSRITDASL-------F 618

  Fly   490 PISRL-RGLKELNLRGCRNVTDSSLMVGL-KLPELRALSLGYCNRLTSEGFEALTQNCPSLEALC 552
            .:|:| :.|:.::...|.|:||:.:.... ....::.:....|..||:.....|. :.|.|:.:.
Yeast   619 QLSKLGKNLQTVHFGHCFNITDNGVRALFHSCTRIQYVDFACCTNLTNRTLYELA-DLPKLKRIG 682

  Fly   553 VSSCMAVDDETVLNIVSNLKR---LRVLNLSNCTKLTLQSIHHIL 594
            :..|..:.||.:||:||...|   |..::||.|:.||:..|:.:|
Yeast   683 LVKCTQMTDEGLLNMVSLRGRNDTLERVHLSYCSNLTIYPIYELL 727

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12402	NP_001303481.1	F-box	75..117	CDD:279040
		leucine-rich repeat	281..303	CDD:275381	4/21 (19%)
		LRR_RI	<297..482	CDD:238064	48/255 (19%)
		leucine-rich repeat	304..330	CDD:275381	12/62 (19%)
		leucine-rich repeat	331..357	CDD:275381	6/43 (14%)
		leucine-rich repeat	358..379	CDD:275381	4/20 (20%)
		leucine-rich repeat	384..409	CDD:275381	5/24 (21%)
		leucine-rich repeat	412..437	CDD:275381	2/27 (7%)
		AMN1	430..595	CDD:187754	46/170 (27%)
		leucine-rich repeat	438..464	CDD:275381	8/25 (32%)
		leucine-rich repeat	465..496	CDD:275381	10/31 (32%)
		leucine-rich repeat	497..521	CDD:275381	5/24 (21%)
		leucine-rich repeat	522..547	CDD:275381	4/24 (17%)
		leucine-rich repeat	548..573	CDD:275381	8/24 (33%)
		leucine-rich repeat	574..599	CDD:275381	8/21 (38%)
GRR1	NP_012623.1	F-box-like	320..361	CDD:403981	10/53 (19%)
		AMN1	404..559	CDD:187754	24/156 (15%)
		leucine-rich repeat	416..441	CDD:275381	7/24 (29%)
		leucine-rich repeat	442..467	CDD:275381	3/24 (13%)
		leucine-rich repeat	494..519	CDD:275381	4/24 (17%)
		leucine-rich repeat	520..545	CDD:275381	5/26 (19%)
		leucine-rich repeat	546..574	CDD:275381	2/27 (7%)
		AMN1	<574..737	CDD:187754	45/163 (28%)
		leucine-rich repeat	575..600	CDD:275381	8/25 (32%)
		leucine-rich repeat	601..626	CDD:275381	10/31 (32%)
		leucine-rich repeat	627..652	CDD:275381	5/24 (21%)
		leucine-rich repeat	653..677	CDD:275381	4/24 (17%)
		leucine-rich repeat	678..704	CDD:275381	8/25 (32%)
		leucine-rich repeat	707..732	CDD:275381	8/21 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810