DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12402 and FBXL20

DIOPT Version :9

Sequence 1:	NP_001303481.1	Gene:	CG12402 / 41714	FlyBaseID:	FBgn0038202	Length:	671	Species:	Drosophila melanogaster
Sequence 2:	NP_001357137.1	Gene:	FBXL20 / 84961	HGNCID:	24679	Length:	473	Species:	Homo sapiens

Alignment Length:	504	Identity:	127/504 - (25%)
Similarity:	199/504 - (39%)	Gaps:	140/504 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   169 KHLQVRH---------------APVFRNLDGKLPNLKVLTIATTMSMDDQHLAAMDDLDMKQFSH 218
            :|:|.|.               |.:|.|.|..:.|.|:                ..:|.::.||.
Human    28 RHIQKRRKMAPSRDRLLHFGFKATMFSNSDEAVINKKL----------------PKELLLRIFSF 76

  Fly   219 LVGFECDGVSLDAVLKMRMLLQLRRTENKVQL------RHLQFEFRRNNENALLDVLQDHAETLV 277
                      ||.|...| ..|:.|..|.:.|      |...|:|:|:.|..:::
Human    77 ----------LDVVTLCR-CAQVSRAWNVLALDGSNWQRIDLFDFQRDIEGRVVE---------- 120

  Fly   278 CVNLFFSCSPGIDTREWCRAFENMHNLRTLKLSGNCHLVLLEAVLRAVPESA-PIRQLDLTGMLS 341
                      .|..|  |..|     ||.|.|.| | |.:.:..||...::. .|..|:|.|...
Human   121 ----------NISKR--CGGF-----LRKLSLRG-C-LGVGDNALRTFAQNCRNIEVLNLNGCTK 166

  Fly   342 LTNELLLYVAGKWQSTLKVLDLMFCVQLNANCIDALRQLSGRLEALTMAYCRELTGTG---LLQG 403
            .|:.....:: |:.|.|:.|||..|..:....:.||.:....||.|.:::|.::|..|   |::|
Human   167 TTDATCTSLS-KFCSKLRHLDLASCTSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQALVRG 230

  Fly   404 LAGDINYSLQELHLEETIFLDESSMCQLLERLPNLRRLSLDNCRQAVTDRTMATICQYQTRLRNL 468
            ..|                               |:.|.|..|.| :.|..:..|..:...|..|
Human   231 CGG-------------------------------LKALFLKGCTQ-LEDEALKYIGAHCPELVTL 263

  Fly   469 NIEYCMKITDQGLMGYGDTPYPISRLRG---LKELNLRGCRNVTDSSL-MVGLKLPELRALSLGY 529
            |::.|::|||:||         |:..||   |:.|...||.|:||:.| .:|...|.||.|.:..
Human   264 NLQTCLQITDEGL---------ITICRGCHKLQSLCASGCSNITDAILNALGQNCPRLRILEVAR 319

  Fly   530 CNRLTSEGFEALTQNCPSLEALCVSSCMAVDDETVLNIVSNLKRLRVLNLSNCTKLTLQSIHHIL 594
            |::||..||..|.:||..||.:.:..|:.:.|.|::.:..:..||:||:||:|..:|...|.| |
Human   320 CSQLTDVGFTTLARNCHELEKMDLEECVQITDSTLIQLSIHCPRLQVLSLSHCELITDDGIRH-L 383

  Fly   595 AHGHNLVQLIACSIDGMDHEQAQRILESQRPQMKQVLLXQERYIHXRSR 643
            .:|       ||:     |:|.:.|.....|.:....| ..:..| ..|
Human   384 GNG-------ACA-----HDQLEVIELDNCPLITDASLEHLKSCHSLER 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12402	NP_001303481.1	F-box	75..117	CDD:279040
		leucine-rich repeat	281..303	CDD:275381	4/21 (19%)
		LRR_RI	<297..482	CDD:238064	48/188 (26%)
		leucine-rich repeat	304..330	CDD:275381	9/26 (35%)
		leucine-rich repeat	331..357	CDD:275381	6/25 (24%)
		leucine-rich repeat	358..379	CDD:275381	7/20 (35%)
		leucine-rich repeat	384..409	CDD:275381	9/27 (33%)
		leucine-rich repeat	412..437	CDD:275381	0/24 (0%)
		AMN1	430..595	CDD:187754	55/168 (33%)
		leucine-rich repeat	438..464	CDD:275381	7/25 (28%)
		leucine-rich repeat	465..496	CDD:275381	10/30 (33%)
		leucine-rich repeat	497..521	CDD:275381	9/24 (38%)
		leucine-rich repeat	522..547	CDD:275381	11/24 (46%)
		leucine-rich repeat	548..573	CDD:275381	5/24 (21%)
		leucine-rich repeat	574..599	CDD:275381	11/24 (46%)
FBXL20	NP_001357137.1	F-box-like	64..106	CDD:338561	13/68 (19%)
		leucine-rich repeat	102..129	CDD:275381	8/48 (17%)
		AMN1	130..326	CDD:355707	67/239 (28%)
		leucine-rich repeat	130..149	CDD:275381	9/20 (45%)
		leucine-rich repeat	156..181	CDD:275381	6/25 (24%)
		leucine-rich repeat	182..207	CDD:275381	7/24 (29%)
		leucine-rich repeat	208..233	CDD:275381	8/24 (33%)
		leucine-rich repeat	234..259	CDD:275381	7/25 (28%)
		AMN1	257..431	CDD:355707	59/186 (32%)
		leucine-rich repeat	260..285	CDD:275381	12/33 (36%)
		leucine-rich repeat	286..311	CDD:275381	9/24 (38%)
		leucine-rich repeat	312..337	CDD:275381	11/24 (46%)
		leucine-rich repeat	338..363	CDD:275381	5/24 (21%)
		leucine-rich repeat	364..392	CDD:275381	14/40 (35%)
		leucine-rich repeat	393..417	CDD:275381	3/23 (13%)
		leucine-rich repeat	418..443	CDD:275381	1/3 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13318
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010