DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12402 and VFB1

DIOPT Version :9

Sequence 1:	NP_001303481.1	Gene:	CG12402 / 41714	FlyBaseID:	FBgn0038202	Length:	671	Species:	Drosophila melanogaster
Sequence 2:	NP_175151.1	Gene:	VFB1 / 841121	AraportID:	AT1G47056	Length:	518	Species:	Arabidopsis thaliana

Alignment Length:	464	Identity:	104/464 - (22%)
Similarity:	182/464 - (39%)	Gaps:	119/464 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   220 VGFECD--GVSL--DAVLKMRMLLQLRRTENKVQLRHLQFEFRRNNENALLDV-LQDHAETLVCV 279
            :..:||  .||:  :|::|:.:     |..|   |:.|:....|.    |.|| :...||.  |.
plant   106 LSLKCDRRSVSIGDEALVKISL-----RCRN---LKRLKLRACRE----LTDVGMAAFAEN--CK 156

  Fly   280 NL-FFSC------SPGIDTREWCRAFENMHNLRTLKLSGNCHLVLLEAVLRAVPESAPIRQLDLT 337
            :| .|||      :.|:..     ..::..||..|.:..          ||...:.||    ::.
plant   157 DLKIFSCGSCDFGAKGVKA-----VLDHCSNLEELSIKR----------LRGFTDIAP----EMI 202

  Fly   338 GMLSLTNELLLYVAGKWQSTLKVLDLMFCVQ--LNANCIDALRQLSGRLEALTMAYCRELTGTG- 399
            |            .|...|:||.:    |::  .|..|...:...:..|::|.:..|     :|
plant   203 G------------PGVAASSLKSI----CLKELYNGQCFGPVIVGAKNLKSLKLFRC-----SGD 246

  Fly   400 ---LLQGLAGDINYSLQELHLE----ETIFLDESSMCQLLERLPNLRRLSLDNCRQAVTDRTMAT 457
               |||.::|. ::.:.|:|||    ..:.|...|.|..||   :|..:....|    |:..:|.
plant   247 WDLLLQEMSGK-DHGVVEIHLERMQVSDVALSAISYCSSLE---SLHLVKTPEC----TNFGLAA 303

  Fly   458 ICQYQTRLRNLNIE--YCMKITDQGLMGYGDTPYPISRL-RGLKELNLRGCRNVTDSSLMVGLKL 519
            |.:...|||.|:|:  ....|.|:||:.       :::. ..|:||.|.|....|.|..|:..|.
plant   304 IAEKCKRLRKLHIDGWKANLIGDEGLVA-------VAKFCSQLQELVLIGVNPTTLSLGMLAAKC 361

  Fly   520 PELRALSLGYCNRLTSEGFEALTQNCPSLEALCVSSCMAVDDETVLNIVSNLKRLRVLNLSNCTK 584
            ..|..|:|..|:.........:...||:|..||:.:| .:.|..:.|:.:....|..:.:..|..
plant   362 LNLERLALCGCDTFGDPELSCIAAKCPALRKLCIKNC-PISDVGIENLANGCPGLTKVKIKKCKG 425

  Fly   585 LT------LQSIHHILAHGHNLVQLIACSIDGMDHEQAQR---ILESQR-----PQMKQVLLXQE 635
            :.      |:::..:|:...:.::        .:||:|..   :..||.     ||:...::...
plant   426 VLGGCADWLRTVRPMLSVNADTME--------QEHEEAASNDVVGGSQENGIEFPQLNSQIMASS 482

  Fly   636 RYIHXRSRN 644
              |...|||
plant   483 --IASSSRN 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12402	NP_001303481.1	F-box	75..117	CDD:279040
		leucine-rich repeat	281..303	CDD:275381	5/28 (18%)
		LRR_RI	<297..482	CDD:238064	45/196 (23%)
		leucine-rich repeat	304..330	CDD:275381	4/25 (16%)
		leucine-rich repeat	331..357	CDD:275381	2/25 (8%)
		leucine-rich repeat	358..379	CDD:275381	5/22 (23%)
		leucine-rich repeat	384..409	CDD:275381	8/28 (29%)
		leucine-rich repeat	412..437	CDD:275381	9/28 (32%)
		AMN1	430..595	CDD:187754	40/173 (23%)
		leucine-rich repeat	438..464	CDD:275381	5/25 (20%)
		leucine-rich repeat	465..496	CDD:275381	8/33 (24%)
		leucine-rich repeat	497..521	CDD:275381	9/23 (39%)
		leucine-rich repeat	522..547	CDD:275381	5/24 (21%)
		leucine-rich repeat	548..573	CDD:275381	6/24 (25%)
		leucine-rich repeat	574..599	CDD:275381	4/30 (13%)
VFB1	NP_175151.1	F-box-like	41..>70	CDD:403981
		AMN1	87..>202	CDD:187754	29/128 (23%)
		leucine-rich repeat	103..125	CDD:275381	5/18 (28%)
		leucine-rich repeat	132..157	CDD:275381	9/30 (30%)
		leucine-rich repeat	158..182	CDD:275381	5/28 (18%)
		leucine-rich repeat	183..224	CDD:275381	13/70 (19%)
		leucine-rich repeat	235..260	CDD:275381	8/30 (27%)
		leucine-rich repeat	261..284	CDD:275381	7/22 (32%)
		AMN1	271..>412	CDD:187754	40/155 (26%)
		leucine-rich repeat	285..310	CDD:275381	7/31 (23%)
		leucine-rich repeat	311..338	CDD:275381	8/33 (24%)
		leucine-rich repeat	339..363	CDD:275381	9/23 (39%)
		leucine-rich repeat	364..389	CDD:275381	5/24 (21%)
		leucine-rich repeat	390..414	CDD:275381	6/24 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13318
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910