DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12402 and COI1

DIOPT Version :9

Sequence 1:	NP_001303481.1	Gene:	CG12402 / 41714	FlyBaseID:	FBgn0038202	Length:	671	Species:	Drosophila melanogaster
Sequence 2:	NP_565919.1	Gene:	COI1 / 818581	AraportID:	AT2G39940	Length:	592	Species:	Arabidopsis thaliana

Alignment Length:	677	Identity:	129/677 - (19%)
Similarity:	211/677 - (31%)	Gaps:	228/677 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 KDKEGSSKAAIELLPNEMWLEI-----------MSYLSYNDLLQLRMVSWRCRDLVHRRRFMEKG 118
            ||::.:|      |....|.:|           :.|.:..|.|..|..:.|...|        ||
plant    32 KDRDSAS------LVCRRWFKIDSETREHVTMALCYTATPDRLSRRFPNLRSLKL--------KG 82

  Fly   119 KVIVTQHNLEAIHKHAKGGNCYLSFERIEL-RNLRQCRQLENFLRLVGHEVKHLQVRHAPVFRNL 182
            |......||  |.::..|   |::....|: .||||.:.:.                    ||.:
plant    83 KPRAAMFNL--IPENWGG---YVTPWVTEISNNLRQLKSVH--------------------FRRM 122

  Fly   183 DGKLPNLKVLTIATTMSMDDQHLAAMDDLDMKQFSHLVGFECDGVSLDAVLKMRMLLQLRRTENK 247
                       |.:.:.:|....|..|||:..:.....||..||: |..|...|.:..|...|:.
plant   123 -----------IVSDLDLDRLAKARADDLETLKLDKCSGFTTDGL-LSIVTHCRKIKTLLMEESS 175

  Fly   248 VQLRHLQFEFRRNNENALLDVLQDHAETLVCVNLFFSCSPGIDTREWCRAFENMHNLRTLKLSGN 312
            ..          ..:...|..|..|..:|..:|.:.:....|..::......|..:|.::|: |:
plant   176 FS----------EKDGKWLHELAQHNTSLEVLNFYMTEFAKISPKDLETIARNCRSLVSVKV-GD 229

  Fly   313 CHLVLLEAVLRAVPESAPIRQLDLTGMLSLTNELLLYVAGKWQSTL----KVLDLMFCVQLNANC 373
            ..:                  |:|.|.......|..:..|.....:    |.::|:|..:|   |
plant   230 FEI------------------LELVGFFKAAANLEEFCGGSLNEDIGMPEKYMNLVFPRKL---C 273

  Fly   374 IDALRQLSGRLEALTMAYCRELTGTGLLQGLAGDINYSLQELHLEETIFLDESSMCQLLERLPNL 438
            ...|..:......:...:..::....||..|                  |:....|.|:::.|||
plant   274 RLGLSYMGPNEMPILFPFAAQIRKLDLLYAL------------------LETEDHCTLIQKCPNL 320

  Fly   439 RRLSLDNCRQAVTDRTMATICQYQTRLRNLNIE-------------------------------- 471
            ..|   ..|..:.||.:..:.||..:|:.|.||
plant   321 EVL---ETRNVIGDRGLEVLAQYCKQLKRLRIERGADEQGMEDEEGLVSQRGLIALAQGCQELEY 382

  Fly   472 ---YCMKITDQGLMGYGD-------------------TPYPISRLRGLKELNLRGCR-------- 506
               |...||::.|...|.                   |..|:.  .|::.| |.||:
plant   383 MAVYVSDITNESLESIGTYLKNLCDFRLVLLDREERITDLPLD--NGVRSL-LIGCKKLRRFAFY 444

  Fly   507 ----NVTDSSL-MVGLKLPELRALSLGYCNRLTSEGFEALTQNCPSLEALCVSSCMAVDDETVLN 566
                .:||..| .:|...|.:|.:.|||... :.||....::.||:|:.|.:..| ...:..:..
plant   445 LRQGGLTDLGLSYIGQYSPNVRWMLLGYVGE-SDEGLMEFSRGCPNLQKLEMRGC-CFSERAIAA 507

  Fly   567 IVSNLKRLRVLNLSNCTKLTLQSIHHILAHGHNLVQLIACSIDGMDHEQAQRILESQRPQMKQVL 631
            .|:.|..||.|                      .||....|:.|.|      :::..||.....|
plant   508 AVTKLPSLRYL----------------------WVQGYRASMTGQD------LMQMARPYWNIEL 544

  Fly   632 LXQERYIHXRSRNTPHHNDWGNHEDDE 658
            :        .||..|..|..|...:.|
plant   545 I--------PSRRVPEVNQQGEIREME 563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12402	NP_001303481.1	F-box	75..117	CDD:279040	9/52 (17%)
		leucine-rich repeat	281..303	CDD:275381	2/21 (10%)
		LRR_RI	<297..482	CDD:238064	37/223 (17%)
		leucine-rich repeat	304..330	CDD:275381	3/25 (12%)
		leucine-rich repeat	331..357	CDD:275381	5/25 (20%)
		leucine-rich repeat	358..379	CDD:275381	6/24 (25%)
		leucine-rich repeat	384..409	CDD:275381	3/24 (13%)
		leucine-rich repeat	412..437	CDD:275381	3/24 (13%)
		AMN1	430..595	CDD:187754	47/231 (20%)
		leucine-rich repeat	438..464	CDD:275381	7/25 (28%)
		leucine-rich repeat	465..496	CDD:275381	11/84 (13%)
		leucine-rich repeat	497..521	CDD:275381	8/36 (22%)
		leucine-rich repeat	522..547	CDD:275381	7/24 (29%)
		leucine-rich repeat	548..573	CDD:275381	5/24 (21%)
		leucine-rich repeat	574..599	CDD:275381	3/24 (13%)
COI1	NP_565919.1	F-box_5	13..54	CDD:408301	6/27 (22%)
		Transp_inhibit	73..119	CDD:408562	15/78 (19%)
		leucine-rich repeat	75..113	CDD:275381	13/50 (26%)
		AMN1	<110..>219	CDD:187754	27/150 (18%)
		leucine-rich repeat	114..139	CDD:275381	5/55 (9%)
		leucine-rich repeat	140..165	CDD:275381	7/25 (28%)
		leucine-rich repeat	166..193	CDD:275381	5/36 (14%)
		leucine-rich repeat	194..221	CDD:275381	4/26 (15%)
		leucine-rich repeat	222..245	CDD:275381	6/41 (15%)
		AMN1	269..443	CDD:187754	34/200 (17%)
		leucine-rich repeat	295..319	CDD:275381	6/41 (15%)
		leucine-rich repeat	320..343	CDD:275381	7/25 (28%)
		leucine-rich repeat	344..379	CDD:275381	4/34 (12%)
		leucine-rich repeat	380..404	CDD:275381	5/23 (22%)
		leucine-rich repeat	405..437	CDD:275381	7/34 (21%)
		leucine-rich repeat	438..464	CDD:275381	4/25 (16%)
		leucine-rich repeat	465..489	CDD:275381	7/24 (29%)
		AMN1	<476..>515	CDD:187754	9/39 (23%)
		leucine-rich repeat	490..514	CDD:275381	5/24 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900