DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG12402 and FBXL15

DIOPT Version :9

Sequence 1:NP_001303481.1 Gene:CG12402 / 41714 FlyBaseID:FBgn0038202 Length:671 Species:Drosophila melanogaster
Sequence 2:XP_005270206.1 Gene:FBXL15 / 79176 HGNCID:28155 Length:387 Species:Homo sapiens


Alignment Length:287 Identity:72/287 - (25%)
Similarity:115/287 - (40%) Gaps:64/287 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   316 VLLEAVLRAVPESAPIRQLDLTGMLSLTNELL--LYVAGKWQSTLKVLDLMFCVQL-----NANC 373
            |||..||..|    |:|||.....:|.....|  |::||     |:..|   ..|:     .|..
Human   114 VLLPHVLNRV----PLRQLLRLQRVSRAFRSLVQLHLAG-----LRRFD---AAQVGPQIPRAAL 166

  Fly   374 IDALRQLSGRLEALTMAYCRELTGTGLLQGLAGDINYSLQELHLEETIFLDESSMCQLLERLPNL 438
            ...||...| |:.|.:|.|.|                           :|.:..:..:|.|.|.|
Human   167 ARLLRDAEG-LQELALAPCHE---------------------------WLSDEDLVPVLARNPQL 203

  Fly   439 RRLSLDNCRQAVTDRTMATICQYQTRLRNLNIEYCMKITDQGLMGYGDTPYPISRLRGLKELNLR 503
            |.::|..|.| ::.|.:..:.:...||:.|::.:|..:....|.|..|      |...|:||:|.
Human   204 RSVALGGCGQ-LSRRALGALAEGCPRLQRLSLAHCDWVDGLALRGLAD------RCPALEELDLT 261

  Fly   504 GCRNVTDSSL--MVGLKLPELRALSLGYCNRLTSEGFEALTQNCPSLEALCVSSCMAVDDETVLN 566
            .||.:.|.::  :...:...||:|||.....:.....:.|.:|||.|..|.::.|:.|..:.|..
Human   262 ACRQLKDEAIVYLAQRRGAGLRSLSLAVNANVGDAAVQELARNCPELHHLDLTGCLRVGSDGVRT 326

  Fly   567 IVSNLKRLRVLNLSNCTKLTLQSIHHI 593
            :......||.|.:.:|        ||:
Human   327 LAEYCPVLRSLRVRHC--------HHV 345

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG12402NP_001303481.1 F-box 75..117 CDD:279040
leucine-rich repeat 281..303 CDD:275381
LRR_RI <297..482 CDD:238064 41/172 (24%)
leucine-rich repeat 304..330 CDD:275381 6/13 (46%)
leucine-rich repeat 331..357 CDD:275381 8/27 (30%)
leucine-rich repeat 358..379 CDD:275381 5/25 (20%)
leucine-rich repeat 384..409 CDD:275381 5/24 (21%)
leucine-rich repeat 412..437 CDD:275381 3/24 (13%)
AMN1 430..595 CDD:187754 44/166 (27%)
leucine-rich repeat 438..464 CDD:275381 6/25 (24%)
leucine-rich repeat 465..496 CDD:275381 7/30 (23%)
leucine-rich repeat 497..521 CDD:275381 7/25 (28%)
leucine-rich repeat 522..547 CDD:275381 8/24 (33%)
leucine-rich repeat 548..573 CDD:275381 5/24 (21%)
leucine-rich repeat 574..599 CDD:275381 6/20 (30%)
FBXL15XP_005270206.1 F-box 105..>142 CDD:279040 11/31 (35%)
leucine-rich repeat 149..175 CDD:275381 6/28 (21%)
leucine-rich repeat 176..202 CDD:275381 8/52 (15%)
leucine-rich repeat 203..228 CDD:275381 6/25 (24%)
AMN1 <226..>353 CDD:187754 35/134 (26%)
leucine-rich repeat 229..254 CDD:275381 7/30 (23%)
leucine-rich repeat 255..281 CDD:275381 7/25 (28%)
leucine-rich repeat 282..307 CDD:275381 8/24 (33%)
leucine-rich repeat 308..332 CDD:275381 5/23 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR13318
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
22.010

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