DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12402 and Fbxl20

DIOPT Version :9

Sequence 1:	NP_001303481.1	Gene:	CG12402 / 41714	FlyBaseID:	FBgn0038202	Length:	671	Species:	Drosophila melanogaster
Sequence 2:	XP_006534361.1	Gene:	Fbxl20 / 72194	MGIID:	1919444	Length:	438	Species:	Mus musculus

Alignment Length:	482	Identity:	124/482 - (25%)
Similarity:	193/482 - (40%)	Gaps:	125/482 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   176 APVFRNLDGKLPNLKVLTIATTMSMDDQHLAAMDDLDMKQFSHLVGFECDGVSLDAVLKMRMLLQ 240
            |.:|.|.|..:.|.|:                ..:|.::.||.          ||.|...| ..|
Mouse    15 ATMFSNSDEAVINKKL----------------PKELLLRIFSF----------LDVVTLCR-CAQ 52

  Fly   241 LRRTENKVQL------RHLQFEFRRNNENALLDVLQDHAETLVCVNLFFSCSPGIDTREWCRAFE 299
            :.|..|.:.|      |...|:|:|:.|..:::                    .|..|  |..|
Mouse    53 VSRAWNVLALDGSNWQRIDLFDFQRDIEGRVVE--------------------NISKR--CGGF- 94

  Fly   300 NMHNLRTLKLSGNCHLVLLEAVLRAVPESA-PIRQLDLTGMLSLTNELLLYVAGKWQSTLKVLDL 363
                ||.|.|.| | |.:.:..||...::. .|..|.|.|....|:.....:: |:.|.|:.|||
Mouse    95 ----LRKLSLRG-C-LGVGDNALRTFAQNCRNIEVLSLNGCTKTTDATCTSLS-KFCSKLRHLDL 152

  Fly   364 MFCVQLNANCIDALRQLSGRLEALTMAYCRELTGTG---LLQGLAGDINYSLQELHLEETIFLDE 425
            ..|..:....:.||.:....||.|.:::|.::|..|   |::|..|
Mouse   153 ASCTSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQALVRGCGG------------------- 198

  Fly   426 SSMCQLLERLPNLRRLSLDNCRQAVTDRTMATICQYQTRLRNLNIEYCMKITDQGLMGYGDTPYP 490
                        |:.|.|..|.| :.|..:..|..:...|..||::.|::|||:||
Mouse   199 ------------LKALFLKGCTQ-LEDEALKYIGAHCPELVTLNLQTCLQITDEGL--------- 241

  Fly   491 ISRLRG---LKELNLRGCRNVTDSSL-MVGLKLPELRALSLGYCNRLTSEGFEALTQNCPSLEAL 551
            |:..||   |:.|...||.|:||:.| .:|...|.||.|.:..|::||..||..|.:||..||.:
Mouse   242 ITICRGCHKLQSLCASGCSNITDAILNALGQNCPRLRILEVARCSQLTDVGFTTLARNCHELEKM 306

  Fly   552 CVSSCMAVDDETVLNIVSNLKRLRVLNLSNCTKLTLQSIHHILAHGHNLVQLIACSIDGMDHEQA 616
            .:..|:.:.|.|::.:..:..||:||:||:|..:|...|.| |.:|       ||:     |:|.
Mouse   307 DLEECVQITDSTLIQLSIHCPRLQVLSLSHCELITDDGIRH-LGNG-------ACA-----HDQL 358

  Fly   617 QRILESQRPQMKQVLLXQERYIHXRSR 643
            :.|.....|.:....| ..:..| ..|
Mouse   359 EVIELDNCPLITDASLEHLKSCHSLER 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12402	NP_001303481.1	F-box	75..117	CDD:279040
		leucine-rich repeat	281..303	CDD:275381	4/21 (19%)
		LRR_RI	<297..482	CDD:238064	48/188 (26%)
		leucine-rich repeat	304..330	CDD:275381	9/26 (35%)
		leucine-rich repeat	331..357	CDD:275381	6/25 (24%)
		leucine-rich repeat	358..379	CDD:275381	7/20 (35%)
		leucine-rich repeat	384..409	CDD:275381	9/27 (33%)
		leucine-rich repeat	412..437	CDD:275381	0/24 (0%)
		AMN1	430..595	CDD:187754	55/168 (33%)
		leucine-rich repeat	438..464	CDD:275381	7/25 (28%)
		leucine-rich repeat	465..496	CDD:275381	10/30 (33%)
		leucine-rich repeat	497..521	CDD:275381	9/24 (38%)
		leucine-rich repeat	522..547	CDD:275381	11/24 (46%)
		leucine-rich repeat	548..573	CDD:275381	5/24 (21%)
		leucine-rich repeat	574..599	CDD:275381	11/24 (46%)
Fbxl20	XP_006534361.1	F-box-like	30..71	CDD:403981	12/67 (18%)
		leucine-rich repeat	67..94	CDD:275381	8/48 (17%)
		AMN1	95..291	CDD:187754	67/239 (28%)
		leucine-rich repeat	95..114	CDD:275381	9/20 (45%)
		leucine-rich repeat	121..146	CDD:275381	6/25 (24%)
		leucine-rich repeat	147..172	CDD:275381	7/24 (29%)
		leucine-rich repeat	173..198	CDD:275381	8/24 (33%)
		leucine-rich repeat	199..224	CDD:275381	7/25 (28%)
		AMN1	222..396	CDD:187754	59/186 (32%)
		leucine-rich repeat	225..250	CDD:275381	12/33 (36%)
		leucine-rich repeat	251..276	CDD:275381	9/24 (38%)
		leucine-rich repeat	277..302	CDD:275381	11/24 (46%)
		leucine-rich repeat	303..328	CDD:275381	5/24 (21%)
		leucine-rich repeat	329..357	CDD:275381	14/40 (35%)
		leucine-rich repeat	358..382	CDD:275381	3/23 (13%)
		leucine-rich repeat	383..408	CDD:275381	1/3 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13318
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010