DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12402 and Fbxl2

DIOPT Version :9

Sequence 1:	NP_001303481.1	Gene:	CG12402 / 41714	FlyBaseID:	FBgn0038202	Length:	671	Species:	Drosophila melanogaster
Sequence 2:	NP_848739.1	Gene:	Fbxl2 / 72179	MGIID:	1919429	Length:	423	Species:	Mus musculus

Alignment Length:	380	Identity:	102/380 - (26%)
Similarity:	161/380 - (42%)	Gaps:	98/380 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   296 RAFENMHN-----LRTLKLSGNCHLVLLEAVLRAVPESA-PIRQLDLTGMLSLTNELLLYVAGKW 354
            |..||:..     ||.|.|.| | :.:.::.|:...::. .|..|:|.|...:|:. ..|...::
Mouse    67 RVVENISKRCGGFLRKLSLRG-C-IGVGDSSLKTFAQNCRNIEHLNLNGCTKITDS-TCYSLSRF 128

  Fly   355 QSTLKVLDLMFCVQLNANCIDALRQLSGRLEALTMAYCRELTGTG---LLQGLAGDINYSLQELH 416
            .|.||.|||..||.:..:.:..:.:....||.|.:::|.::|..|   |::|..|
Mouse   129 CSKLKHLDLTSCVSVTNSSLKGISEGCRNLEYLNLSWCDQITKEGIEALVRGCRG---------- 183

  Fly   417 LEETIFLDESSMCQLLERLPNLRRLSLDNCRQAVTDRTMATICQYQTRLRNLNIEYCMKITDQGL 481
                                 |:.|.|..|.| :.|..:..|..:...|.:||::.|.:|||.|:
Mouse   184 ---------------------LKALLLRGCTQ-LEDEALKHIQNHCHELVSLNLQSCSRITDDGV 226

  Fly   482 MGYGDTPYPISRLRG---LKELNLRGCRNVTDSSL-MVGLKLPELRALSLGYCNRLTSEGFEALT 542
                     :...||   |:.|.|.||.|:||:|| .:||..|.|:.|....|:.||..||..|.
Mouse   227 ---------VQICRGCHRLQALCLSGCSNLTDASLTALGLNCPRLQVLEAARCSHLTDAGFTLLA 282

  Fly   543 QN--------------------------CPSLEALCVSSCMAVDDETVLNIVSNL---KRLRVLN 578
            :|                          ||.|:||.:|.|..:.||.:|::.|:.   :|||||.
Mouse   283 RNCHELEKMDLEECVLITDSTLVQLSIHCPKLQALSLSHCELITDEGILHLSSSTCGHERLRVLE 347

  Fly   579 LSNCTKLTLQSIHHI-LAHGHNLVQLIACSIDGMDHEQAQRI----LESQRPQMK 628
            |.||..:|..|:.|: ...|...::|..|       :|..|.    :.:|.|.:|
Mouse   348 LDNCLLVTDASLEHLENCRGLERLELYDC-------QQVTRAGIKRMRAQLPHVK 395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12402	NP_001303481.1	F-box	75..117	CDD:279040
		leucine-rich repeat	281..303	CDD:275381	3/6 (50%)
		LRR_RI	<297..482	CDD:238064	47/193 (24%)
		leucine-rich repeat	304..330	CDD:275381	7/26 (27%)
		leucine-rich repeat	331..357	CDD:275381	6/25 (24%)
		leucine-rich repeat	358..379	CDD:275381	7/20 (35%)
		leucine-rich repeat	384..409	CDD:275381	9/27 (33%)
		leucine-rich repeat	412..437	CDD:275381	0/24 (0%)
		AMN1	430..595	CDD:187754	61/198 (31%)
		leucine-rich repeat	438..464	CDD:275381	7/25 (28%)
		leucine-rich repeat	465..496	CDD:275381	8/30 (27%)
		leucine-rich repeat	497..521	CDD:275381	12/24 (50%)
		leucine-rich repeat	522..547	CDD:275381	10/50 (20%)
		leucine-rich repeat	548..573	CDD:275381	9/27 (33%)
		leucine-rich repeat	574..599	CDD:275381	11/25 (44%)
Fbxl2	NP_848739.1	F-box-like	15..57	CDD:289689
		leucine-rich repeat	52..79	CDD:275381	3/11 (27%)
		LRR 1	61..87		7/19 (37%)
		AMN1	<76..223	CDD:187754	42/181 (23%)
		leucine-rich repeat	80..99	CDD:275381	7/20 (35%)
		Interaction with Calmodulin. /evidence=ECO:0000269\|PubMed:21343341	80..90		6/11 (55%)
		LRR 2	88..113		5/25 (20%)
		leucine-rich repeat	106..131	CDD:275381	6/25 (24%)
		LRR 3	114..139		8/25 (32%)
		leucine-rich repeat	132..157	CDD:275381	7/24 (29%)
		LRR 4	140..165		5/24 (21%)
		leucine-rich repeat	158..183	CDD:275381	8/24 (33%)
		LRR 5	166..191		9/55 (16%)
		AMN1	168..367	CDD:187754	66/239 (28%)
		leucine-rich repeat	184..209	CDD:275381	7/25 (28%)
		LRR 6	192..217		7/25 (28%)
		leucine-rich repeat	210..235	CDD:275381	10/33 (30%)
		LRR 7	218..243		10/33 (30%)
		leucine-rich repeat	236..261	CDD:275381	12/24 (50%)
		LRR 8	244..269		11/24 (46%)
		leucine-rich repeat	262..287	CDD:275381	9/24 (38%)
		LRR 9	270..295		7/24 (29%)
		leucine-rich repeat	288..313	CDD:275381	1/24 (4%)
		LRR 10	296..321		5/24 (21%)
		leucine-rich repeat	314..336	CDD:275381	8/21 (38%)
		LRR 11	322..350		11/27 (41%)
		leucine-rich repeat	343..362	CDD:275381	9/18 (50%)
		LRR 12	351..375		6/23 (26%)
		LRR 13	376..401		6/27 (22%)
		CAAX motif	420..423
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13318
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010