DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12402 and Fbxl15

DIOPT Version :9

Sequence 1:	NP_001303481.1	Gene:	CG12402 / 41714	FlyBaseID:	FBgn0038202	Length:	671	Species:	Drosophila melanogaster
Sequence 2:	NP_001365702.1	Gene:	Fbxl15 / 68431	MGIID:	1915681	Length:	336	Species:	Mus musculus

Alignment Length:	219	Identity:	54/219 - (24%)
Similarity:	91/219 - (41%)	Gaps:	45/219 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   377 LRQLSGRLEALTMAYCRELTGTGLLQGLAGDINYSLQELHLEETIFLDESSMCQLLERLPNLRRL 441
            ||...| |:.|.:|.|.|                           :|.:..:..:|.|.|.||.:
Mouse   119 LRDAEG-LQELALAPCHE---------------------------WLSDEDLVPVLARNPQLRSV 155

  Fly   442 SLDNCRQAVTDRTMATICQYQTRLRNLNIEYCMKITDQGLMGYGDTPYPISRLRGLKELNLRGCR 506
            :|..|.| ::.|.:..:.:...||:.|::.:|..:....|.|..|      |...|:||:|..||
Mouse   156 ALAGCGQ-LSRRALGALAEGCPRLQRLSLAHCDWVDGLALRGLAD------RCPALEELDLTACR 213

  Fly   507 NVTDSSL--MVGLKLPELRALSLGYCNRLTSEGFEALTQNCPSLEALCVSSCMAVDDETVLNIVS 569
            .:.|.::  :...:...||:|||.....:.....:.|.:|||.||.|.::.|:.|..:.|..:..
Mouse   214 QLKDEAIVYLAQRRGAGLRSLSLAVNANVGDTAVQELARNCPQLEHLDLTGCLRVGSDGVRTLAE 278

  Fly   570 NLKRLRVLNLSNCTKLTLQSIHHI 593
            ....||.|.:.:|        ||:
Mouse   279 YCPALRSLRVRHC--------HHV 294

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12402	NP_001303481.1	F-box	75..117	CDD:279040
		leucine-rich repeat	281..303	CDD:275381
		LRR_RI	<297..482	CDD:238064	22/104 (21%)
		leucine-rich repeat	304..330	CDD:275381
		leucine-rich repeat	331..357	CDD:275381
		leucine-rich repeat	358..379	CDD:275381	1/1 (100%)
		leucine-rich repeat	384..409	CDD:275381	5/24 (21%)
		leucine-rich repeat	412..437	CDD:275381	3/24 (13%)
		AMN1	430..595	CDD:187754	45/166 (27%)
		leucine-rich repeat	438..464	CDD:275381	6/25 (24%)
		leucine-rich repeat	465..496	CDD:275381	7/30 (23%)
		leucine-rich repeat	497..521	CDD:275381	7/25 (28%)
		leucine-rich repeat	522..547	CDD:275381	8/24 (33%)
		leucine-rich repeat	548..573	CDD:275381	6/24 (25%)
		leucine-rich repeat	574..599	CDD:275381	6/20 (30%)
Fbxl15	NP_001365702.1	F-box	18..55	CDD:395521
		leucine-rich repeat	125..151	CDD:275381	8/52 (15%)
		leucine-rich repeat	152..177	CDD:275381	6/25 (24%)
		AMN1	<175..>304	CDD:187754	36/134 (27%)
		leucine-rich repeat	178..203	CDD:275381	7/30 (23%)
		leucine-rich repeat	204..230	CDD:275381	7/25 (28%)
		leucine-rich repeat	231..256	CDD:275381	8/24 (33%)
		leucine-rich repeat	257..281	CDD:275381	6/23 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13318
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910