DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12402 and Fbxl20

DIOPT Version :9

Sequence 1:	NP_001303481.1	Gene:	CG12402 / 41714	FlyBaseID:	FBgn0038202	Length:	671	Species:	Drosophila melanogaster
Sequence 2:	XP_017453008.1	Gene:	Fbxl20 / 64039	RGDID:	621722	Length:	453	Species:	Rattus norvegicus

Alignment Length:	429	Identity:	115/429 - (26%)
Similarity:	178/429 - (41%)	Gaps:	99/429 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   229 LDAVLKMRMLLQLRRTENKVQL------RHLQFEFRRNNENALLDVLQDHAETLVCVNLFFSCSP 287
            ||.|...| ..|:.|..|.:.|      |...|:|:|:.|..:::
  Rat    57 LDVVTLCR-CAQVSRAWNVLALDGSNWQRIDLFDFQRDIEGRVVE-------------------- 100

  Fly   288 GIDTREWCRAFENMHNLRTLKLSGNCHLVLLEAVLRAVPESA-PIRQLDLTGMLSLTNELLLYVA 351
            .|..|  |..|     ||.|.|.| | |.:.:..||...::. .|..|.|.|....|:.....::
  Rat   101 NISKR--CGGF-----LRKLSLRG-C-LGVGDNALRTFAQNCRNIEVLSLNGCTKTTDATCTSLS 156

  Fly   352 GKWQSTLKVLDLMFCVQLNANCIDALRQLSGRLEALTMAYCRELTGTG---LLQGLAGDINYSLQ 413
             |:.|.|:.|||..|..:....:.||.:....||.|.:::|.::|..|   |::|..|
  Rat   157 -KFCSKLRHLDLASCTSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQALVRGCGG------- 213

  Fly   414 ELHLEETIFLDESSMCQLLERLPNLRRLSLDNCRQAVTDRTMATICQYQTRLRNLNIEYCMKITD 478
                                    |:.|.|..|.| :.|..:..|..:...|..||::.|::|||
  Rat   214 ------------------------LKALFLKGCTQ-LEDEALKYIGAHCPELVTLNLQTCLQITD 253

  Fly   479 QGLMGYGDTPYPISRLRG---LKELNLRGCRNVTDSSL-MVGLKLPELRALSLGYCNRLTSEGFE 539
            :||         |:..||   |:.|...||.|:||:.| .:|...|.||.|.:..|::||..||.
  Rat   254 EGL---------ITICRGCHKLQSLCASGCSNITDAILNALGQNCPRLRILEVARCSQLTDVGFT 309

  Fly   540 ALTQNCPSLEALCVSSCMAVDDETVLNIVSNLKRLRVLNLSNCTKLTLQSIHHILAHGHNLVQLI 604
            .|.:||..||.:.:..|:.:.|.|::.:..:..||:||:||:|..:|...|.| |.:|
  Rat   310 TLARNCHELEKMDLEECVQITDSTLIQLSIHCPRLQVLSLSHCELITDDGIRH-LGNG------- 366

  Fly   605 ACSIDGMDHEQAQRILESQRPQMKQVLLXQERYIHXRSR 643
            ||:     |:|.:.|.....|.:....| ..:..| ..|
  Rat   367 ACA-----HDQLEVIELDNCPLITDASLEHLKSCHSLER 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12402	NP_001303481.1	F-box	75..117	CDD:279040
		leucine-rich repeat	281..303	CDD:275381	4/21 (19%)
		LRR_RI	<297..482	CDD:238064	48/188 (26%)
		leucine-rich repeat	304..330	CDD:275381	9/26 (35%)
		leucine-rich repeat	331..357	CDD:275381	6/25 (24%)
		leucine-rich repeat	358..379	CDD:275381	7/20 (35%)
		leucine-rich repeat	384..409	CDD:275381	9/27 (33%)
		leucine-rich repeat	412..437	CDD:275381	0/24 (0%)
		AMN1	430..595	CDD:187754	55/168 (33%)
		leucine-rich repeat	438..464	CDD:275381	7/25 (28%)
		leucine-rich repeat	465..496	CDD:275381	10/30 (33%)
		leucine-rich repeat	497..521	CDD:275381	9/24 (38%)
		leucine-rich repeat	522..547	CDD:275381	11/24 (46%)
		leucine-rich repeat	548..573	CDD:275381	5/24 (21%)
		leucine-rich repeat	574..599	CDD:275381	11/24 (46%)
Fbxl20	XP_017453008.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910