DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12402 and Lrrc29

DIOPT Version :9

Sequence 1:	NP_001303481.1	Gene:	CG12402 / 41714	FlyBaseID:	FBgn0038202	Length:	671	Species:	Drosophila melanogaster
Sequence 2:	XP_006255593.1	Gene:	Lrrc29 / 502201	RGDID:	1593150	Length:	673	Species:	Rattus norvegicus

Alignment Length:	669	Identity:	177/669 - (26%)
Similarity:	268/669 - (40%)	Gaps:	148/669 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 SKAAIELLP-------NEMWLEIMSYLSYNDLLQLRMVS--WRCRDLVHRRRFMEKGKVIVTQHN 126
            |||...|.|       .:|...|:|:|..:|..:..:||  |........|....:..:.|:..:
  Rat    43 SKALRVLTPLKHLIFSPQMLTYILSFLPLSDQKEASLVSRAWYYAAQNALRETNVRYNIPVSSAS 107

  Fly   127 LEAIHKHAKGG-NCYLSFERIELRNLRQCRQLENFLRLVGHEV-KHLQ----------------- 172
            |.||....:.| :|      |.|.||.........|:.|.:.: .|||
  Rat   108 LSAIKSLGRRGISC------ISLTNLDGSPASHQVLQSVAYHLGPHLQSLCLGGGSPTEASFLAL 166

  Fly   173 VRHAPVFRNLD----------GKL---PNLKVLTIATTMSMDDQHLAAMDDLDMKQFSHLVGFEC 224
            :...||.|.||          |.|   |............:.|.:||.:.||....|:||  ..|
  Rat   167 ILGCPVLRTLDLSGCNSLFTSGTLLAQPETAQCVRKALSGLRDLNLAGLRDLTDLSFNHL--SSC 229

  Fly   225 DGVSLDAVLKMRMLLQLRRTENKVQLRHLQFEF--------------RRNNENALLDVLQDHAET 275
                         ...|.|.  .:...||.||.              .:.:.:.||..:::.|.|
  Rat   230 -------------FPSLERL--SLAYCHLTFELGSTWGSTSPQASSPSQLSFHNLLQFIKERAGT 279

  Fly   276 LVCVNLFFSCSPGIDTREWCRAFENMHNLRTLKLS----GNCHLVLLEAVLRAVPESAPIRQLDL 336
            |..::|..:..|.       .|.:.:..:..|||.    .:|..:..|||.....:...:..|||
  Rat   280 LRALDLSGTGLPP-------EALQALGQVTGLKLEELNLNSCKDLSSEAVATLCRQQPGLTSLDL 337

  Fly   337 TGMLSLTNELLLYVAGKWQSTLKVLDLMFCVQL-NANCIDALRQLSGRLEALTMAYCRELTGTGL 400
            :|...||:..||.|: :....|:.|.|....:| :|.|| ||..|. .|::|.||.|..::|..|
  Rat   338 SGCSELTDRALLAVS-RGLHHLRHLSLKKLQRLTDAGCI-ALGALH-ELQSLDMAECCLVSGREL 399

  Fly   401 LQGLAGDINY---SLQELHLEETIFLDESSMCQLLERL-PNLRRLSLDNCRQAVTDRTMATICQY 461
            .|.| |.:..   :|..|.|.....|.::|:..::..| |:|:.|.|.:| .|:|::||..||.|
  Rat   400 AQVL-GSVRRAPPALTSLRLAYCSSLKDASVLSMIPALGPSLKVLDLSSC-VALTNQTMQAICTY 462

  Fly   462 QTRLRNLNIEYCMKITDQGLMGY---GDTPY------------------PISR--------LRGL 497
            ...|..|.:.:|.::.|.||:|.   .|.|.                  |.|.        |:.|
  Rat   463 LIHLSVLRLAWCKELQDWGLLGLKEPSDEPVLNPQLHQEVENQAPDHQEPSSEPQGSSLLMLQAL 527

  Fly   498 KELNLRGCRNVTDSSLMVGLKLPELRALSLGYCNRLTSEGFEALTQNCPSLEALCVSSCMAVDDE 562
            :||:|..|..:||:||...|:.|:||.|||......|..|..|:.:.|||||.|.:|.|..:.||
  Rat   528 QELDLTACSKLTDASLAKVLQFPQLRQLSLSLLPAFTDMGLVAVARGCPSLERLTLSHCSHLSDE 592

  Fly   563 TVLNIVSNLKRLRVLNLSNCTKLTLQSIHHILAHGHNLVQL-----IAC---SIDGMDHEQAQRI 619
            ..:.......||:.||||:|:::|.|::..|   |....||     ..|   ::..:.|.||
  Rat   593 GWVQAARLWPRLQHLNLSSCSQVTEQTLDTI---GQACKQLRVLDVAMCPGINMAAVKHFQA--- 651

  Fly   620 LESQRPQMKQVLLXQERYI 638
                  |:.||...|.|::
  Rat   652 ------QLPQVTCIQSRFV 664

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12402	NP_001303481.1	F-box	75..117	CDD:279040	11/50 (22%)
		leucine-rich repeat	281..303	CDD:275381	3/21 (14%)
		LRR_RI	<297..482	CDD:238064	60/193 (31%)
		leucine-rich repeat	304..330	CDD:275381	7/29 (24%)
		leucine-rich repeat	331..357	CDD:275381	9/25 (36%)
		leucine-rich repeat	358..379	CDD:275381	9/21 (43%)
		leucine-rich repeat	384..409	CDD:275381	10/24 (42%)
		leucine-rich repeat	412..437	CDD:275381	6/25 (24%)
		AMN1	430..595	CDD:187754	64/194 (33%)
		leucine-rich repeat	438..464	CDD:275381	11/25 (44%)
		leucine-rich repeat	465..496	CDD:275381	12/59 (20%)
		leucine-rich repeat	497..521	CDD:275381	10/23 (43%)
		leucine-rich repeat	522..547	CDD:275381	9/24 (38%)
		leucine-rich repeat	548..573	CDD:275381	7/24 (29%)
		leucine-rich repeat	574..599	CDD:275381	10/24 (42%)
Lrrc29	XP_006255593.1	leucine-rich repeat	124..142	CDD:275381	5/17 (29%)
		LRR_RI	<170..410	CDD:238064	67/267 (25%)
		leucine-rich repeat	173..206	CDD:275381	6/32 (19%)
		leucine-rich repeat	207..232	CDD:275381	9/39 (23%)
		leucine-rich repeat	233..279	CDD:275381	9/47 (19%)
		leucine-rich repeat	280..300	CDD:275381	4/26 (15%)
		AMN1	292..480	CDD:187754	58/199 (29%)
		leucine-rich repeat	306..331	CDD:275381	5/24 (21%)
		leucine-rich repeat	332..357	CDD:275381	9/25 (36%)
		leucine-rich repeat	358..439	CDD:275381	26/83 (31%)
		leucine-rich repeat	383..408	CDD:275381	10/25 (40%)
		leucine-rich repeat	413..437	CDD:275381	5/23 (22%)
		leucine-rich repeat	440..465	CDD:275381	11/25 (44%)
		leucine-rich repeat	466..526	CDD:275381	12/59 (20%)
		leucine-rich repeat	527..577	CDD:275381	20/49 (41%)
		AMN1	<564..>638	CDD:187754	26/76 (34%)
		leucine-rich repeat	578..603	CDD:275381	7/24 (29%)
		leucine-rich repeat	604..629	CDD:275381	10/27 (37%)
		leucine-rich repeat	630..655	CDD:275381	6/33 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D161790at33208
OrthoFinder	1	1.000	-	-		FOG0003012
OrthoInspector	1	1.000	-	-		otm45240
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820