DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12402 and Fbxl7

DIOPT Version :9

Sequence 1:	NP_001303481.1	Gene:	CG12402 / 41714	FlyBaseID:	FBgn0038202	Length:	671	Species:	Drosophila melanogaster
Sequence 2:	NP_795933.2	Gene:	Fbxl7 / 448987	MGIID:	3052506	Length:	491	Species:	Mus musculus

Alignment Length:	634	Identity:	130/634 - (20%)
Similarity:	227/634 - (35%)	Gaps:	239/634 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 LSCSYAQTPNR----------MELNLNPLLAIARSIAAPPT------------------------ 53
            :|.|...||.:          .:|::..|...:.::..|||
Mouse    23 VSSSTDHTPTKAQRNVATSEDSDLSMRTLSTPSPALICPPTLPGFQNGRGSSTSSSSITGETVAM 87

  Fly    54 ---PPPTP-----EKLDSDKDKEGSSKAAIELLPNEMWLEIMSYLSYNDLLQLRMVSWRCRDLVH 110
               ||||.     .:|.|...||   :|:|:.||:...::|.|:|..|.|         ||
Mouse    88 VHSPPPTRLTHPLIRLASRPQKE---QASIDRLPDHSMVQIFSFLPTNQL---------CR---- 136

  Fly   111 RRRFMEKGKVIVTQHNLEAIHKHAKGGNCYLSFERIELRNLRQCRQLENF---------LRLVGH 166
                                        |           .|.||:..|.         :||.|.
Mouse   137 ----------------------------C-----------ARVCRRWYNLAWDPRLWRTIRLTGE 162

  Fly   167 EVKHLQVRHAPVFRNLDGKLPNLKVLTIATTMSMDDQHLAAMDDLDMKQFSHLVGFECDGVSLDA 231
            .:            |:|..   |||||  ..:..|..::..|                    |:.
Mouse   163 TI------------NVDRA---LKVLT--RRLCQDTPNVCLM--------------------LET 190

  Fly   232 VLKMRMLLQLRRTENKVQLRHLQFEFRRNNENALLDVLQDHAETLVCVNLFFSCSPGIDTREWCR 296
            |:....                    ||..:..|..:.|              |.|
Mouse   191 VIVSGC--------------------RRLTDRGLYTIAQ--------------CCP--------- 212

  Fly   297 AFENMHNLRTLKLSGNCHLVLLEAVLRAVPESAPIRQLDLTG-----MLSLTNELLLYVA---GK 353
                  .||.|::|| |:.:..|||...|.....:..||::|     .:|||.|..:.::   ||
Mouse   213 ------ELRRLEVSG-CYNISNEAVFDVVSLCPNLEHLDVSGCSKVTCISLTREASIKLSPLHGK 270

  Fly   354 WQSTLKVLDLMFCVQLNANCIDALRQLSGRLEALTMAYCRELTGTGLLQGLAGDINYSLQELHLE 418
             |.:::.||:..|..|....:..:           .|:|.:||                 .|:|.
Mouse   271 -QISIRYLDMTDCFVLEDEGLHTI-----------AAHCTQLT-----------------HLYLR 306

  Fly   419 ETIFLDESSMCQLLERLPNLRRLSLDNCRQAVTDRTMATICQYQTRLRNLNIEYCMKITDQGLMG 483
            ..:.|.:..:..|:....:::.||:.:|| .|:|..:..|.:.::|||.|:|.:|.:|||.|:.
Mouse   307 RCVRLTDEGLRYLVIYCTSIKELSVSDCR-FVSDFGLREIAKLESRLRYLSIAHCGRITDVGIR- 369

  Fly   484 YGDTPYPISRLRGLKELNLRGCRNVTDSSL-MVGLKLPELRALSLGYCNRLTSEGFEALTQNCPS 547
                 |.......|:.||.|||..:||..: .:.....:|::|.:|.|..::..|.|:|..||.:
Mouse   370 -----YVAKYCSKLRYLNARGCEGITDHGVEYLAKNCTKLKSLDIGKCPLVSDTGLESLALNCFN 429

  Fly   548 LEALCVSSCMAVDDETVLNIVSNLKRLRVLNLSNCTKLTLQSIHHILAH 596
            |:.|.:.||.::..:.:..:.:|...|::||:.:| :::::::..:..|
Mouse   430 LKRLSLKSCESITGQGLQIVAANCFDLQMLNVQDC-EVSVEALRFVKRH 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12402	NP_001303481.1	F-box	75..117	CDD:279040	10/41 (24%)
		leucine-rich repeat	281..303	CDD:275381	2/21 (10%)
		LRR_RI	<297..482	CDD:238064	49/192 (26%)
		leucine-rich repeat	304..330	CDD:275381	10/25 (40%)
		leucine-rich repeat	331..357	CDD:275381	10/33 (30%)
		leucine-rich repeat	358..379	CDD:275381	4/20 (20%)
		leucine-rich repeat	384..409	CDD:275381	4/24 (17%)
		leucine-rich repeat	412..437	CDD:275381	4/24 (17%)
		AMN1	430..595	CDD:187754	45/165 (27%)
		leucine-rich repeat	438..464	CDD:275381	7/25 (28%)
		leucine-rich repeat	465..496	CDD:275381	10/30 (33%)
		leucine-rich repeat	497..521	CDD:275381	8/24 (33%)
		leucine-rich repeat	522..547	CDD:275381	9/24 (38%)
		leucine-rich repeat	548..573	CDD:275381	5/24 (21%)
		leucine-rich repeat	574..599	CDD:275381	5/23 (22%)
Fbxl7	NP_795933.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..79		9/55 (16%)
		F-box-like	114..160	CDD:289689	16/97 (16%)
		leucine-rich repeat	129..151	CDD:275381	10/73 (14%)
		leucine-rich repeat	154..187	CDD:275381	11/49 (22%)
		AMN1	<185..366	CDD:187754	56/280 (20%)
		LRR 1	185..210		7/78 (9%)
		leucine-rich repeat	188..213	CDD:275381	8/73 (11%)
		LRR 2	211..236		11/40 (28%)
		leucine-rich repeat	214..234	CDD:275381	9/20 (45%)
		LRR 3	237..262		7/24 (29%)
		leucine-rich repeat	240..273	CDD:275381	10/33 (30%)
		LRR 4	271..296		5/35 (14%)
		leucine-rich repeat	274..299	CDD:275381	6/35 (17%)
		AMN1	297..464	CDD:187754	50/190 (26%)
		LRR 5	297..322		7/41 (17%)
		leucine-rich repeat	300..325	CDD:275381	6/41 (15%)
		LRR 6	323..348		7/25 (28%)
		leucine-rich repeat	326..351	CDD:275381	7/25 (28%)
		LRR 7	349..374		11/30 (37%)
		leucine-rich repeat	352..377	CDD:275381	10/30 (33%)
		LRR 8	375..400		8/24 (33%)
		leucine-rich repeat	378..403	CDD:275381	8/24 (33%)
		LRR 9	401..426		7/24 (29%)
		leucine-rich repeat	404..429	CDD:275381	9/24 (38%)
		LRR 10	427..452		5/24 (21%)
		leucine-rich repeat	430..453	CDD:275381	4/22 (18%)
		leucine-rich repeat	456..480	CDD:275381	5/23 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810