DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12402 and CG32085

DIOPT Version :9

Sequence 1:	NP_001303481.1	Gene:	CG12402 / 41714	FlyBaseID:	FBgn0038202	Length:	671	Species:	Drosophila melanogaster
Sequence 2:	NP_729732.1	Gene:	CG32085 / 39311	FlyBaseID:	FBgn0052085	Length:	666	Species:	Drosophila melanogaster

Alignment Length:	719	Identity:	141/719 - (19%)
Similarity:	238/719 - (33%)	Gaps:	250/719 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 GNSLITSGKPSQRREKRLFERLSCSYAQTPNRMELNLNPLLAIARSIAAPPT---PPPTPEKLDS 63
            |||...||..|.                       |.|...|.|.:..:|.:   ||.||
  Fly    76 GNSNSNSGSNSS-----------------------NSNTSSASATAATSPASNANPPQTP----- 112

  Fly    64 DKDKEGSSKAAIEL-LPNEMWLEIMSYLSYNDLLQLRMVSWRCRDLVHRRRFMEKGKVIVTQHNL 127
            ||...|||.:...: :|.                                   .:.:|..:.|:|
  Fly   113 DKPSRGSSPSPGGITMPG-----------------------------------GQSQVQNSTHHL 142

  Fly   128 EAIHKHAKGGNCYLSFERIELRNLRQCRQLENFLRLVGHEVKHLQVRHAPVFRNLDGKLPNLKVL 192
                                   |:|.:|.:..::|...:.:|||::
  Fly   143 -----------------------LQQQQQQQQHMQLQQSQQQHLQLQ------------------ 166

  Fly   193 TIATTMSMDDQH------------LAAMDDLDMKQFSHLVGFECDGVSLD----AVLKMRML--- 238
              |:|:...:.|            |.|.....:|..:..:.....|..::    ....|.|:
  Fly   167 --ASTLINSNHHVMVGPAPPTGMPLGAPPTPTVKSIAKQMNITIPGGGVNPGSPTFSTMGMVAAQ 229

  Fly   239 ----------LQLRRTENKVQLRHLQFEFRRNNENALLDVLQDH---------AETLVCVNLFFS 284
                      ||||:   ::...||...:.....||...::..|         .|.|:..:.|.|
  Fly   230 KAAASAGGTPLQLRK---QLPNPHLHHPYGSMGINAASPLIMQHQLHPPPIHSIEQLMLDDRFLS 291

  Fly   285 -----------------CSPGIDT-----REW--------CRAFENMHNLRTLKLSGNCHLVLLE 319
                             |....||     |.|        ||....|......|        |..
  Fly   292 RFFQYFSPYERRILAQVCIKWRDTLYRSPRYWSGLLPTLQCRELRQMPGCDRGK--------LYN 348

  Fly   320 AVLRAVPESAPIRQLDLTGMLSLTNELLLYV------AGKWQSTLKVLDLMFCVQLNANCIDALR 378
            :::|        |.....|::..::|..|.|      |.|...:|.    :.|..::...::.|.
  Fly   349 SLIR--------RGFHALGLVGASDEDALDVVHSFPLASKHVHSLS----LRCSSISDRGLETLL 401

  Fly   379 QLSGRLEALTMAYCRELTGTGLLQGLAGDINYSLQELHLEETIFLDESSMCQLLERLPNLRRLSL 443
            .....|..|.:|.|.|:|..||...|...|    ..|.|.:.|.:.:.::..:.:.||:|...||
  Fly   402 DHLQSLFELELAGCNEVTEAGLWACLTPRI----VSLSLADCINIADEAVGAVAQLLPSLYEFSL 462

  Fly   444 DNCRQA--VTDRTMATICQYQTR-LRNLNIEYCMKITDQGLMGYGDTPYPISRLRGLKELNLRGC 505
                ||  |||..:......|:. |..|.::.|.::|:.|::..      :..|..|..|:|.||
  Fly   463 ----QAYHVTDAALGYFSPKQSHSLSILRLQSCWELTNHGIVNI------VHSLPHLTVLSLSGC 517

  Fly   506 RNVTDSSL-MVGLKLPELRALSLGYCNRLTSEGFEALTQNCPSLEALCVSSCMAVDD------ET 563
            ..:||..: ::...|.:||||.|.:|.|:|....|.:..:...||.|.:..|:.:.|      .|
  Fly   518 SKLTDDGVELIAENLQKLRALDLSWCPRITDASLEYIACDLNQLEELTLDRCVHITDIGVGYIST 582

  Fly   564 VLNIVS------------------NLKRLRVLNLSNCTKLTLQSIHHILAHGHNLVQLIACSIDG 610
            :|::.:                  :::.|:||:|:.|..||...:..::...| |.:|...:..|
  Fly   583 MLSLTALFLRWCSQVRDFGLQHLCSMRNLQVLSLAGCPLLTSSGLSSLIQLRH-LQELELTNCPG 646

  Fly   611 MDHE 614
            ..||
  Fly   647 ASHE 650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12402	NP_001303481.1	F-box	75..117	CDD:279040	1/42 (2%)
		leucine-rich repeat	281..303	CDD:275381	10/51 (20%)
		LRR_RI	<297..482	CDD:238064	43/193 (22%)
		leucine-rich repeat	304..330	CDD:275381	3/25 (12%)
		leucine-rich repeat	331..357	CDD:275381	7/31 (23%)
		leucine-rich repeat	358..379	CDD:275381	3/20 (15%)
		leucine-rich repeat	384..409	CDD:275381	9/24 (38%)
		leucine-rich repeat	412..437	CDD:275381	4/24 (17%)
		AMN1	430..595	CDD:187754	48/192 (25%)
		leucine-rich repeat	438..464	CDD:275381	9/27 (33%)
		leucine-rich repeat	465..496	CDD:275381	6/30 (20%)
		leucine-rich repeat	497..521	CDD:275381	8/24 (33%)
		leucine-rich repeat	522..547	CDD:275381	9/24 (38%)
		leucine-rich repeat	548..573	CDD:275381	7/48 (15%)
		leucine-rich repeat	574..599	CDD:275381	7/24 (29%)
CG32085	NP_729732.1	leucine-rich repeat	382..406	CDD:275381	3/27 (11%)
		AMN1	383..600	CDD:187754	57/234 (24%)
		leucine-rich repeat	431..456	CDD:275381	5/28 (18%)
		leucine-rich repeat	457..482	CDD:275381	9/28 (32%)
		leucine-rich repeat	483..508	CDD:275381	6/30 (20%)
		leucine-rich repeat	509..534	CDD:275381	8/24 (33%)
		leucine-rich repeat	535..560	CDD:275381	9/24 (38%)
		leucine-rich repeat	561..585	CDD:275381	6/23 (26%)
		leucine-rich repeat	586..610	CDD:275381	0/23 (0%)
		leucine-rich repeat	636..661	CDD:275381	5/15 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45457969
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.830