DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12402 and CG9003

DIOPT Version :9

Sequence 1:	NP_001303481.1	Gene:	CG12402 / 41714	FlyBaseID:	FBgn0038202	Length:	671	Species:	Drosophila melanogaster
Sequence 2:	NP_001097271.1	Gene:	CG9003 / 36244	FlyBaseID:	FBgn0033639	Length:	651	Species:	Drosophila melanogaster

Alignment Length:	456	Identity:	108/456 - (23%)
Similarity:	194/456 - (42%)	Gaps:	80/456 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   193 TIATTMSMDDQHLAAM-DDLDMKQFSHLVGFECDGVSL---DAVLKMRMLLQLRRTE-NKVQLRH 252
            |......:||:.:..: .::.::.||:|     |.|||   ..|.|...:|.|..:. .|:.|
  Fly   228 TFLGATELDDELIKQLPKEVLLRVFSYL-----DVVSLCRCAQVCKYWNVLALDGSSWQKINL-- 285

  Fly   253 LQFEFRRNNENALLDVLQDHAETLVCVNLFFSCSPGIDTREWCRAFENMHNLRTLKLSGNCHLVL 317
              |:|:|:.|..:::.:...                      ||.|     |::|.|.| |..|.
  Fly   286 --FDFQRDIEGPVIENISQR----------------------CRGF-----LKSLSLRG-CQSVG 320

  Fly   318 LEAVLRAVPESAPIRQLDLTGMLSLTNELLLYVAGKWQSTLKVLDLMFCVQLNANCIDALRQLSG 382
            .::|.........|..|||:....:| ::......::.|.|..::|..|..:..|.:..|.....
  Fly   321 DQSVRTLANHCHNIEHLDLSDCKKIT-DISTQSISRYCSKLTAINLHSCSNITDNSLKYLSDGCP 384

  Fly   383 RLEALTMAYCRELTGTG---LLQGLAGDINYS---LQELHLEETIFLDESSMCQLLERLPNLRRL 441
            .|..:.:::|..::..|   |.:|......:|   .::::       |.:.|| |.:..|:|..|
  Fly   385 NLMEINVSWCHLISENGVEALARGCVKLRKFSSKGCKQIN-------DNAIMC-LAKYCPDLMVL 441

  Fly   442 SLDNCRQAVTD---RTMATICQYQTRLRNLNIEYCMKITDQGLMGYGDTPYPISRLRGLKELNLR 503
            :|.:| :.:||   |.:|..|.   :|:.|.:..|..:||..|:......:.      |..|.:.
  Fly   442 NLHSC-ETITDSSIRQLAANCH---KLQKLCVSKCADLTDLTLLSLSQHNHL------LNTLEVS 496

  Fly   504 GCRNVTDSSLM-VGLKLPELRALSLGYCNRLTSEGFEALTQNCPSLEALCVSSCMAVDDETVLNI 567
            ||||.||.... :|.....|..:.|..|:::|......|...|||||.|.:|.|..:.|:.:.::
  Fly   497 GCRNFTDIGFQALGRNCKYLERMDLEECSQITDLTLAHLATGCPSLEKLTLSHCELITDDGIRHL 561

  Fly   568 VSN---LKRLRVLNLSNCTKLTLQSIHHILAHGHNL--VQLIACSIDGMDHEQAQRILESQRPQM 627
            .:.   .:.|.||.|.||..:|.:::.|::: .|||  ::|..|.   :....|.|.|::..|.:
  Fly   562 TTGSCAAEILSVLELDNCPLITDRTLEHLVS-CHNLQRIELFDCQ---LITRTAIRKLKNHLPNI 622

  Fly   628 K 628
            |
  Fly   623 K 623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12402	NP_001303481.1	F-box	75..117	CDD:279040
		leucine-rich repeat	281..303	CDD:275381	3/21 (14%)
		LRR_RI	<297..482	CDD:238064	44/193 (23%)
		leucine-rich repeat	304..330	CDD:275381	7/25 (28%)
		leucine-rich repeat	331..357	CDD:275381	5/25 (20%)
		leucine-rich repeat	358..379	CDD:275381	5/20 (25%)
		leucine-rich repeat	384..409	CDD:275381	5/27 (19%)
		leucine-rich repeat	412..437	CDD:275381	4/24 (17%)
		AMN1	430..595	CDD:187754	48/171 (28%)
		leucine-rich repeat	438..464	CDD:275381	9/28 (32%)
		leucine-rich repeat	465..496	CDD:275381	6/30 (20%)
		leucine-rich repeat	497..521	CDD:275381	9/24 (38%)
		leucine-rich repeat	522..547	CDD:275381	6/24 (25%)
		leucine-rich repeat	548..573	CDD:275381	6/27 (22%)
		leucine-rich repeat	574..599	CDD:275381	8/24 (33%)
CG9003	NP_001097271.1	F-box-like	240..285	CDD:289689	12/49 (24%)
		leucine-rich repeat	280..307	CDD:275381	8/52 (15%)
		AMN1	<308..453	CDD:187754	35/155 (23%)
		leucine-rich repeat	308..327	CDD:275381	7/19 (37%)
		leucine-rich repeat	334..359	CDD:275381	5/25 (20%)
		leucine-rich repeat	360..385	CDD:275381	5/24 (21%)
		leucine-rich repeat	386..411	CDD:275381	5/24 (21%)
		AMN1	<409..586	CDD:187754	51/194 (26%)
		leucine-rich repeat	412..437	CDD:275381	5/32 (16%)
		leucine-rich repeat	438..463	CDD:275381	9/28 (32%)
		leucine-rich repeat	464..515	CDD:275381	15/56 (27%)
		leucine-rich repeat	516..541	CDD:275381	6/24 (25%)
		leucine-rich repeat	542..561	CDD:275381	6/18 (33%)
		leucine-rich repeat	571..595	CDD:275381	8/24 (33%)
		leucine-rich repeat	596..621	CDD:275381	6/27 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45457981
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR13318
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940